Extended Data Fig. 5: Additional GO enrichment, PPI and MCODE network analyses of differentially expressed proteins in eight regions.
From: Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
a) The graph reflects the same networks depicted in Fig. 6b (downregulated GO cluster, left panel) and Fig. 6c (upregulated GO cluster, right panel), but with the regional information displayed as a pie chart for each gene. Each GO term is proportioned within the pie chart and color-coded based on the number of proteins under the term from the corresponding region (key below)42. Most of the terms displayed are shared by more than three regions. b) Merged protein-protein interaction and MCODE network analyses42 of differentially expressed proteins in eight regions. Top GO terms for each MCODE network are selected for labeling.
