Extended Data Fig. 2: Increased ACE2 and FURIN protein expression in the frontal cortex of severe acute/subacute COVID-19 patients. | Nature Aging

Extended Data Fig. 2: Increased ACE2 and FURIN protein expression in the frontal cortex of severe acute/subacute COVID-19 patients.

From: Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection

Extended Data Fig. 2: Increased ACE2 and FURIN protein expression in the frontal cortex of severe acute/subacute COVID-19 patients.

Anti-ACE2 (a) and Anti-FURIN (b) immunohistochemistry highlight the increased protein expression at the vascular/perivascular structures (magenta arrowhead) in the white matter of the COVID-19 patients (N = 9) comparing to the non-COVID controls (N = 8), one-tailed unpaired t-test of area percentage for positive immunoreactivity, p = 3.95E-2 (ACE2) and p = 3.00E-3 (FURIN).

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