Extended Data Fig. 3: Expression of SA-ERVs is gradually upregulated with passaging in normal fibroblasts, but remains unchanged in hTERT-immortalized cells. | Nature Aging

Extended Data Fig. 3: Expression of SA-ERVs is gradually upregulated with passaging in normal fibroblasts, but remains unchanged in hTERT-immortalized cells.

From: Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging

Extended Data Fig. 3

a, The expression patterns of LTR39, MER61C, MER61-int, MSTC, and MST-int during passaging in WI38 and HFF cells by RNA-seq analysis. b, The expression of SA-ERVs (left), and genes related to RIG-I/MDA5-MAVS and IFN-I signaling (right), in PD46 and PD109 hTERT-immortalized WI38 cells by RNA-seq analysis. c, The profiles of ATAC-seq signals in genomic regions of ERV1, ERVK, ERVL, and ERVL-MaLR subfamilies in PD46 and PD109 hTERT-immortalized WI38 cells. Data represent mean ± SEM of three biological replicates (a and b). PD, population doublings.

Source data

Back to article page