Extended Data Fig. 7: Schematic representation of key findings.

Schematic model showing that SA-ERVs activated by ATF3 form dsRNAs through bidirectional transcription, drive IFN-I response via RIG-I/MDA5-MAVS signaling pathway in senescent cells, thereby contributing to SASP and other senescence-associated phenotypes. non-Sen, non-senescent. Sen, senescent.