Extended Data Fig. 1: Upset plot of samples for baseline and at least one follow-up.

The figure shows an upset plot displaying overlap of available datasets across treatment group, tissues, molecular data type. This figure is analogous to Fig. 2a, here only samples with baseline and at least one follow-up (12- or 24-months) are counted. The left-hand side shows tissue type (blood, muscle, or adipose), type of molecular data type (SNPs, DNAm, smRNAs, or mRNA), set size for each tissue and data type combination in number of unique individuals, and group (CR or AL). The bottom right-hand side shows points and connecting lines indicating overlapping intersections across tissues and data types color coded by treatment group (CR = red, AL = navy). The top right hand side shows a barchart indicating sample sizes for the overlapping intersections of tissue and datatypes. Each tissue and molecular data type combination is linked to a corresponding color scheme as follows: genomic variation (purple DNA), blood DNA methylation (red DNA with lollipops), blood small RNAs (smRNAs; dark red RNA fragments), muscle DNA methylation (blue DNA with lollipops), muscle smRNAs (blue RNA fragments), muscle mRNA (blue single RNA strand), adipose DNA methylation (yellow DNA with lollipops), adipose smRNAs (yellow RNA fragments), adipose mRNA (yellow single RNA strand). Created with BioRender.com.