Extended Data Fig. 3: Associations of DNA methylation measures of aging with chronological age.

The figure shows DNA methylation measures of aging (Y-axis) against chronological age (X-axis) for n=212 men and women at pre-intervention baseline. The dashed colored line on each facet is the line of identity (intercept=0, slope=1), indicating where predicted epigenetic age or pace of aging would equal chronological age. Correlations with chronological age are as follows: Horvath Clock r=0.87, PC Horvath Clock r=0.84, Hannum Clock r=0.92, PC Hannum Clock r=0.88, Skin & Blood Clock r=0.94, PC Skin & Blood Clock r=0.80, PhenoAge Clock r=0.84, PC PhenoAge Clock r=0.85, GrimAge Clock r=0.93, PC GrimAge Clock r=0.92, DunedinPACE r=0.15.