Extended Data Fig. 9: Effects of Rapamycin treatment on the expression of astrocyte substate markers in LPS-induced PD-like model, related to Fig. 6.
From: Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration
a, Representative images showing the expression level of neuroprotective substate marker S100A10 in SNc astrocytes. Scale bar, 50 μm. b, Quantification of the expression level of S100A10 in S100β-positive astrocytes. The fold changes of fluorescent intensity were calculated relative to the untreated control group. c, Representative images showing the expression of GFAP in the SNc. Scale bar, 100 μm. d, Quantification of the expression levels of GFAP in c. The fold changes were calculated relative to the untreated control group. All data were presented as mean ± SEM, n = 4 mice per group. *P < 0.05, ***P < 0.001. One-way ANOVA and Tukey’s multiple comparisons test were used for statistical analyses; the exact P values are provided in the Source data.
