Extended Data Fig. 8: Successful overexpression of Gnai3 in HuR-deficient mouse models.
From: mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice
a, Comparison of Anc80L65-control and Anc80L65-Gnai3 transduction efficiency based on HA (green) and Phalloidin (red) staining. Both Anc80L65-control and Anc80L65-Gnai3 were found to efficiently transduce HCs throughout the cochlea. Scale bar, 50 μm. b,c, Histograms showing the percentage of HA-labeled OHCs and IHCs. n = 8 mice. The data are presented as the mean ± standard error of the mean. The P-values were determined by a one-way ANOVA followed by Tukey’s multiple comparison test.
