Extended Data Fig. 6: Distribution of shared somatic mitochondrial mutations across tissues.
From: Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging
This figure displays the number of somatic mutations found in two or more tissues. To investigate the potential developmental origins of these shared mutations, they were categorized based on whether the tissues arise from the same germ layer (endoderm, mesoderm, or ectoderm) or from different germ layers. This analysis helps to understand the potential developmental stage at which these mutations first appeared. Hotspot mutations were analyzed separately, as they may arise independently in different tissues rather than reflecting a shared lineage.
