In November 2023, the Division of Aging Biology of the National Institute on Aging held a workshop to discuss the long-term effects of pregnancy on aging. A synthesis of these discussions and a set of considerations are presented in this Meeting Report.
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References
Jasienska, G. Phil. Trans. R. Soc. Lond. B 375, 20190615 (2020).
Shadyab, A. H. et al. Am. J. Public Health 107, 113–119 (2017).
Sun, F. et al. Menopause 22, 26–31 (2015).
Ryan, C. P. et al. Proc. Natl Acad. Sci. USA 121, e2317290121 (2024).
Galbarczyk, A. et al. Am. J. Phys. Anthropol. 175, 656–664 (2021).
Puri, T. A., Richard, J. E. & Galea, L. A. M. Trends Neurosci. 46, 459–471 (2023).
Barclay, K. & Kolk, M. Eur. J. Popul. 35, 63–85 (2018).
Ang, C. J., Skokan, T. D. & McKinley, K. L. Annu. Rev. Cell Dev. Biol. 39, 197–221 (2023).
Poganik, J. R. et al. Cell Metab. 35, 807–820 (2023).
Pollack, A. Z., Rivers, K. & Ahrens, K. A. Hum. Reprod. 33, 736–744 (2018).
Slaughter-Acey, J. C., Brown, T. N., Keith, V. M., Dailey, R. & Misra, D. P. Soc. Sci. Med. 265, 113552 (2020).
Bytautiene Prewit, E., Kechichian, T., Okunade, D., Yin, H. & Stuebe, A. M. Reprod. Sci. 25, 1186–1196 (2018).
Catov, J. M. et al. Hypertension 79, 424–434 (2022).
Clayton, A. M. et al. Brain Behav. Immun. 70, 376–389 (2018).
Stanhewicz, A. E., Schlarmann, R. L., Brustkern, K. M. & Jalal, D. I. J. Appl. Physiol. 133, 361–370 (2022).
Acknowledgements
The authors thank F. Wang for co-chairing the workshop. Particular thanks go to F. Wang and J. Williams of Division of Aging Biology (https://www.nia.nih.gov/research/dab) of the National Institute on Aging (https://www.nia.nih.gov/) (DAB) for their vision and their critical reading and editing of the manuscript, E. Gorodetsky of the Office of Research on Women’s Health (https://orwh.od.nih.gov/), N. Chakhtoura of the National Institute of Child Health and Human Development (https://www.nichd.nih.gov/), and R. A. Kohanski and S. Carrington-Lawrence of DAB for their scientific guidance. The participation of these individuals or the materials should not be interpreted as representing the official viewpoint of the US Department of Health and Human Services, the National Institutes of Health or the National Institute on Aging, except where noted. We also thank Q. Guo for creating the original illustration for Fig.1.
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K.I.K. and Y.S. wrote and edited this Meeting Report. Each subsequent listed author was a workshop participant and has been listed in alphabetical order, as all authors contributed equally in regards to presenting and summarizing their own work to be published in this report. Workshop participants also provided feedback, edits and comments in the manuscript drafting phase.
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W.T.P. serves as a consultant for Placenta AI. Y.S. is a scientific founder of Perpetual Biosciences. All other authors declare no competing interests.
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Nature Aging thanks Kieran O’Donnell and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Kim, K.I., Bello, N.A., Galea, L.A.M. et al. A National Institute on Aging workshop on the long-term effects of pregnancy on aging. Nat Aging 5, 2372–2375 (2025). https://doi.org/10.1038/s43587-025-00992-1
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DOI: https://doi.org/10.1038/s43587-025-00992-1
