Fig. 4: Mediation analysis of APOE-ε4 on delirium, mediated by all-cause dementia.
From: Dissecting the genetic and proteomic risk factors for delirium
a, Hypothesized directed acyclic graph, showing all-cause dementia as mediator of APOE-ε4 genetic effect on delirium (black arrows), adjusted for baseline covariates: age and sex (gray arrows). b,c, Effect decomposition of the total APOE-ε4 effect, into natural direct (independent of dementia) and natural indirect (mediated through dementia) effects ± 95% CI (n = 407,827 individuals in UKB). The effect of having one APOE-ε4 haplotype (b) and the effect of having two APOE-ε4 haplotypes (c), compared to having none. NDE, natural direct effect; NIE, natural indirect effect.
