Fig. 7: Mendelian randomization results of plasma proteins on delirium.
From: Dissecting the genetic and proteomic risk factors for delirium
MR associations were derived using the IVW or Wald ratio method and UKB delirium GWAS summary statistics. Only significant (two-sided FDR q < 0.05) MR associations are shown. Effects are presented as IVW/Wald ratio log OR ± 95% CI. Replication MR was conducted using delirium GWAS summary statistics from FinnGen. Colors are assigned to proteins based on their significance in the PWAS logistic regression analysis: Bonferroni, unadjusted two-sided P < 1.7 × 10−5; FDR, FDR-adjusted two-sided q < 0.05; nominal, unadjusted two-sided P < 0.05 and having consistent direction of effect.
