Extended Data Fig. 10: GO and KEGG analysis of multi-omics indicates that CDK3 is involved in the regulation of synaptic function, metabolic process, neuron-death and the cell cycle.
From: CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease
(a) GO and KEGG analysis of CDK3 interactor. (b) GO and KEGG analysis of differentially expressed proteins in the proteome with or without CDK3 overexpression. (c) GO and KEGG analysis of differentially expressed proteins in the phosphoproteome with or without CDK3 overexpression. (Hypergeometric test for enrichment. Yellow boxes denote metabolism-associated GO terms and KEGG pathways; red boxes denote synapse-associated GO terms and KEGG pathways; green boxes denote neuron death-associated GO terms and KEGG pathways; pale pink boxes denote Cell cycle-associated GO terms and KEGG pathways; purple boxes denote neurodegenerative disease-associated GO terms and KEGG pathways. Three biological repetitions were performed for each group in three omics.).
