Fig. 3: Clinical outcomes in high → high groups versus TANGO PSM at week 100. | Nature Aging

Fig. 3: Clinical outcomes in high → high groups versus TANGO PSM at week 100.

From: Exploratory analyses of clinical outcomes from the BIIB080 phase 1b study in mild Alzheimer’s disease

Fig. 3: Clinical outcomes in high → high groups versus TANGO PSM at week 100.

For high → high groups, TANGO PSM used 1:1 match and adjusted for seven covariates: CDR-GS (exact match), CDR-SB, MMSE, FAQ, APOE, age and sex. In a and b, changes in clinical outcomes from the MAD baseline to the end of LTE (week 100) were analyzed, and results were based on an ANCOVA model, with treatment group, baseline value and baseline CDR-GS as independent variables. No statistical testing or multiple comparison adjustments were performed. In a, nine participants in cohort D, seven participants in cohort C and 16 participants in the TANGO PSM group had CDR-SB, MMSE and FAQ scores. In b, nine participants in cohort D, seven participants in cohort C and 16 participants in the TANGO PSM group had CDR Memory Box, Orientation, Judgment and Problem Solving, Community Affairs, Home and Hobbies and Personal Care scores. CI, confidence interval; Chg Ctrl., change in control; Diff vs Ctrl., difference versus control.

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