Fig. 4: Supplementary analyses of clinical outcomes in high → high groups versus external controls at week 100.
At week 100, TANGO I/E criteria had an n = 101 for MMSE scores and an n = 99 for FAQ scores. At week 100, ADNI I/E criteria had an n = 40 for MMSE scores. TANGO PSM used 1:1 match and adjusted for seven covariates: CDR-GS (exact match), CDR-SB, MMSE, FAQ, APOE, age and sex. ADNI PSM used 1:1 match and adjusted for five covariates: CDR-GS (exact match), CDR-SB, MMSE, FAQ and APOE. The I/E criteria method selected participants by key inclusion criteria of the BIIB080 phase 1b study. The resample method randomly selected 16 participants from the I/E criteria set, and the results were summarized from 1,000 rounds of resampling. In a and b, changes in clinical outcomes from the MAD baseline to the end of the LTE (week 100) were analyzed, and results were based on an ANCOVA model, with treatment group, baseline value and baseline CDR-GS as independent variables. No statistical testing or multiple comparison adjustments were performed. CI, confidence interval.
