Extended Data Fig. 9: WDFY1 exerts harmful effects on bone independent of TLR3/4 signaling. | Nature Aging

Extended Data Fig. 9: WDFY1 exerts harmful effects on bone independent of TLR3/4 signaling.

From: Brain neuron-derived WDFY1 induces bone loss

Extended Data Fig. 9: WDFY1 exerts harmful effects on bone independent of TLR3/4 signaling.The alternative text for this image may have been generated using AI.

a, b, Femoral μCT images (a) and quantification of Tb. BV/TV, Tb. N, Tb. Th, and Ct. Th (b) in 12-month-old Tlr3−/− male mice treated with AAV2-Con or AAV2-Wdfy1. Scale bar: 1 mm. n = 9 (AAV2-Con) or 10 (AAV2-Wdfy1) per group. c, d, Femoral μCT images (c) and quantification of Tb. BV/TV, Tb. N, Tb. Th, and Ct. Th (d) in 12-month-old Tlr4−/− male mice treated with AAV2-Con or AAV2-Wdfy1. Scale bar: 1 mm. n = 6 (AAV2-Con) or 7 (AAV2-Wdfy1) per group. Data are mean ± SD. Statistics: unpaired, two-tailed Student’s t-test (b and d).

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