Extended Data Fig. 4: Pharmacological inhibitors of LINE-1 reverse transcription or STING signaling attenuate senescence in Mov10-knockout H9C2 cells.
From: Targeting age-related LINE-1 activation alleviates cardiac aging
a-b, qPCR analysis showing Cdkn1a, Cdkn2a, and Lmnb1 mRNA levels in wild-type (WT) and three independent lines of Mov10-knockout (KO-1, KO-2, and KO-3) H9C2 cells treated with 3TC (a) or H-151 (b). n = 6 biological replicates per group. Groups were compared using two-way ANOVA post hoc Tukey test. ***p < 0.001 compared to WT H9C2 cells treated with PBS or DMSO as appropriate; ns, not significant, ###p < 0.001 compared to corresponding WT or KO lines treated with PBS or DMSO as appropriate.
