Extended Data Fig. 10: Pharmacological inhibitor of LINE-1 reverse transcription mitigates cardiac inflammation in Mov10-cKO mice.
From: Targeting age-related LINE-1 activation alleviates cardiac aging
a–c, Immunohistochemical analysis of IL-1β (a), IL-6 (b), and TNF (c) in mouse hearts from each group. Scale bar, 25 µm. Quantitative data on relative signal intensities are shown to the right. n = 6 mice per group. Data are presented as mean ± SEM with individual data points indicated. Groups were compared using two-way ANOVA post hoc Tukey test. ns, not significant, ***p < 0.001 compared to Ctrl + Water group; #p < 0.05 compared to KO + Water group.
