Extended Data Fig. 6: Tendency of PEP in human blood and its effect on the activation of cGAS. | Nature Aging

Extended Data Fig. 6: Tendency of PEP in human blood and its effect on the activation of cGAS.

From: The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging

Extended Data Fig. 6: Tendency of PEP in human blood and its effect on the activation of cGAS.

(a,b) The PEP levels in plasma from male (a) or female (b) human donors with different ages. (c) The PEP levels in plasma from human donors with different age group. (d,e) Correlation analysis between the concentration of PEP and ages (ages 20-56 (d) or ages ≥ 65 (e)). (f) Quantification of cGAS-DNA foci in THP-1 cells cultured with different pooled human serum. (n = 3). Data show the mean ± SD; Each dot represents one independent biological replicate; Simple linear regression in (d,e); One-way ANOVA with Dunnett post hoc test in (f).

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