Extended Data Fig. 7: The glycolytic metabolite phosphoenolpyruvate is a protective factor for healthy ageing via restricting cGAS-STING-mediated inflammation. | Nature Aging

Extended Data Fig. 7: The glycolytic metabolite phosphoenolpyruvate is a protective factor for healthy ageing via restricting cGAS-STING-mediated inflammation.

From: The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging

Extended Data Fig. 7: The glycolytic metabolite phosphoenolpyruvate is a protective factor for healthy ageing via restricting cGAS-STING-mediated inflammation.

(a) Schematic showing that the glycolytic metabolite PEP accumulates at the early stages of aging, while gradually decreases with advanced aging, serving as a beneficial factor in curbing inflammaging and promoting healthy aging by inhibiting the cGAS-STING pathway.

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