Extended Data Fig. 6: Correlation network analysis of genomic features affected by PtbAlnc perturbation.
From: Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence
a, Heatmap of Pearson correlation matrices for differentially expressed genes (DEGs) following PtbAlnc perturbation in non-targeting cells. Seven highly correlated RNA modules were identified through Ward’s hierarchical clustering. b, Heatmap of Pearson correlation matrices for differentially accessible (DA) motifs following PtbAlnc perturbation in non-targeting cells. Six highly correlated ATAC modules were identified through Ward’s hierarchical clustering, with key features annotated for each module. c, Heatmap showing the average chromVAR scores for RNA modules across different PtbAlnc perturbation groups, reflecting the expression abundance within each module. d, Heatmap displaying the average chromVAR scores for ATAC modules across different PtbAlnc perturbation groups, reflecting the chromatin accessibility within each module. e, Dot plot showing fold change in RNA module scores across different PtbAlnc perturbation groups compared to NT cells. f, Dot plot showing fold change in ATAC module scores across different PtbAlnc perturbation groups compared to NT cells.
