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This review summarizes the role of FOXP3 in Treg plasticity, stability and function in axial spondyloarthritis, proposing that Treg dysregulation may contribute to disease pathogenesis and clinical manifestations.
Neural ODEs unify continuous dynamics and neural networks to model cellular dynamics in single-cell omics. This review surveys applications from trajectory modling to gene regulatory network inference, highlighting technical innovations from Optimal Transport to Flow Matching.
We synthesize advances in Acinetobacter T6SS biology, revealing how non-canonical structural solutions and multilayered regulation create an adaptable system for competition, persistence, and host immune modulation.
This Review article explores shared epigenetic mechanisms linking addictive drug use and depression, highlighting DNA methylation, histone modifications and non-coding RNAs as key contributors to their comorbidity.
A review of targeted single-cell RNA sequencing methods provides a practical guide to help researchers select the method most suited for their own experiments.
This Review examines experimental models for evaluating nucleic acid therapeutics, emphasizing the need for effective preclinical models to assess molecular and phenotypic efficacy at each stage of development.
A review summarizes the preparation and regenerative functions of mesenchymal stem cell-derived extracellular matrix (mECM) as a biomimetic material for bone, cartilage, muscle, tendon, and nerve repair, alongside its clinical translation prospects.
This review summarizes how molecular chaperones enable structures of small inactive-state GPCRs by improving particle alignment and effective molecular weight, delivering high-resolution cryo-EM insights and guiding community decisions on stabilization strategies.
