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A gut-on-a-chip incorporating peristaltic-like movements and faecal samples from patients with melanoma recapitulates microbiome–host interactions and predicts the responses of the patients to immune checkpoint inhibitors.
The parallel intracellular recording of neurons via an array of 4,096 microhole electrodes on a semiconductor chip enables the large-scale mapping of synaptic connections, as shown with rat neuronal cultures.
Small circular RNAs encoding one or more antigens and enclosed in subcutaneously injected lipid nanoparticles can elicit potent and durable antitumour T cell responses for robust tumour immunotherapy, particularly in combination with immune checkpoint inhibition, as shown in multiple mouse models of tumours.
Variants of adeno-associated viruses displaying robust and widespread transduction in murine, porcine and non-human-primate kidneys, and in human kidney organoids, can be obtained via the cross-species cycling of capsid libraries in the different kidney models.
Urinary reporters leveraging caged bioorthogonal click handles for the biomarker-dependent activation of ‘clickability’ and renal clearance allow for the monitoring, in urine, of the efficacy of chemotherapy and of associated kidney injury in mice.
Training a model on fetal and paediatric magnetic resonance images with synthesized artefacts enhances the model’s generalization across downstream tasks and patient populations.
Advances in base editing and prime editing, coupled with optimized delivery strategies, are enhancing the efficiency, safety and versatility of genome editing for the treatment of a widening range of genetic diseases.
Intracortical microstimulation of the somatosensory cortex evokes tactile sensations, but those of individual electrodes are insufficient for functional tasks. We show that stimulating multiple electrodes with somatotopically matched projected fields improves task performance with bionic hands.
An interpretable transformer-based model leveraging graph representation learning accurately predicts cancer genes across homogeneous and heterogeneous pan-cancer networks of biological interactions.
A skull-stripping model for magnetic resonance images that leverages personalized priors from atlases of brain scans generates naturally consistent and seamless lifespan changes in brain volume.
The success of haematopoietic stem and progenitor cell (HSPC) transplants, particularly those using cord blood, requires the cells’ engraftment to bone marrow. We discovered that the corticotropin-releasing hormone regulates the biomechanics and homing behaviour of HSPCs, enhancing bone-marrow engraftment through the mechanical remodelling of the cell’s cytoskeleton and the extracellular matrix.
