Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the piK/isuba/sub of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo

Journal:
Angewandte Chemie International Edition
Published:
DOI:
10.1002/anie.202506954
Affiliations:
8
Authors:
14
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Institutions Authors Share
Ghent University (UGent), Belgium
10.333333
10.333333
 0.74
VIB-UGent Center for Inflammation Research (IRC), Belgium
3.000000
 0.21
Ghent University Hospital, Belgium
0.666667
 0.05
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