Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

Journal:

Journal of Biological Chemistry

Published:

2025-07-31

DOI:

10.1016/j.jbc.2025.110548

Affiliations:

7

Authors:

10

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Institutions	Authors	Share
Kyoto University, Japan	4.000000	0.40
The University of Osaka (UOsaka), Japan	1.666667	0.17
RIKEN Center for Computational Science (R-CCS), Japan	1.500000	0.15
National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan	1.500000	0.15
JEOL YOKOGUSHI Research Alliance Laboratories, Japan	1.333333	0.13

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