Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance

Journal:
Journal of Infectious Diseases
Published:
DOI:
10.1093/infdis/jiaf294
Affiliations:
12
Authors:
25
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Institutions Authors Share
Mount Sinai Hospital (MSH), U of T, Canada
7.500000
 0.30
The University of British Columbia (UBC), Canada
6.000000
 0.24
Simon Fraser University (SFU), Canada
4.000000
 0.16
Shared Hospital Laboratory (SHL), Canada
2.666667
 0.11
Sunnybrook Health Sciences Centre, U of T, Canada
1.333333
 0.05
Dalhousie University, Canada
1.166667
 0.05
Montana Molecular, United States of America (USA)
1.000000
 0.04
Vancouver Prostate Centre (VPC), Canada
1.000000
 0.04
University of Toronto (U of T), Canada
0.333333
 0.01
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