Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition

Journal:

Gut

Published:

2026-01-06

DOI:

10.1136/gutjnl-2025-336235

Affiliations:

6

Authors:

10

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Institutions	Authors	Share
Fudan University Shanghai Cancer Center (FUSCC), China	6.600000	0.66
Shanghai Medical College (SHMC), Fudan University, China	2.400000	0.24
University at Buffalo, The State University of New York (SUNY UB), United States of America (USA)	1.000000	0.10

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