Biochemistry and Cell Biology articles for China

Time frame: 1 June 2025 - 30 May 2026

View topic

Count: 789

Article ‘Count’ for Biochemistry and Cell Biology.

Journal Count Share
19 17.80
Magnetic Graphene for High-Performance Isolation of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes via Ca2+-Dependent Reversible Recognition 1.00
Fusogenic Liposome-Mediated Extracellular Vesicles MicroRNA Profiling for Lung Cancer Diagnosis 1.00
Noninvasive, Rapid, and Precise Identification of Esophageal Cancer via Salivary Extracellular Vesicle-Based Diagnosis 0.75
Deterministic Evolution of Aptamers via a Microfluidic-Integrated Robotic Platform Using Complex Exosomes as Targets 1.00
Separation-Free Extracellular Vesicle Microribonucleic Acid Profiling Using Structurally Oriented Membrane Fusion and Spatially Confined Amplification 1.00
Sr-, Ca-Doped BaTiO3 with Synergistic Piezoelectric Catalysis and Microbial Balance Effects Enables Tooth Whitening for Home Oral Health 1.00
Enhanced Delivery of Oral Biomacromolecules through Edible Plant-Derived Nanovehicles: Exploiting the Self-Amplifying Trancytosis Feedback Loop and Phosphatidic Acid 1.00
Interferon-γ-Induced Mesenchymal Stem Cell Exosomes Attenuate Chondrocyte Senescence and Osteoarthritis Progression by Hsp70 1.00
AI-Guided Hydrophobic Core Design of Robust Six-Helix Bundle Proteins 1.00
Modular Nanoassemblies Mimicking p62 Aggregates for Targeted Organelle Sequestration and Degradation against Breast Cancer 1.00
Hydrogel Loaded with Aminoethyl Anisamide-Modified Exosomes Attenuates Hepatic Fibrosis by Targeting Activated Hepatic Stellate Cells 1.00
Revealing the Role of Actin Cytoskeleton in Herpes Simplex Virus Type 1–Endosome Membrane Fusion by Single-Virus Tracking 1.00
A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senescence-Associated Phenotypes 1.00
Dual-Targeting Mn@CeO2 Nanozyme-Modified Probiotic Hydrogel Microspheres Reshape Gut Homeostasis in Inflammatory Bowel Disease 1.00
Orchestrating Gut Disorders by Oral Delivery of a Living–Synthetic Hybrid Hydrogel 1.00
Fluid Nanoforest Interfaces for Efficient Capture and iIn Situ/i MicroRNA and Protein Profiling of Tumor-Derived Extracellular Vesicles 1.00
Dissecting Exosomal–Tumoral–Vascular Interactions of Single Tumor Cells and Clusters Using a Tumoral-Transendothelial Migration Chip 0.47
Engineering Liposomes with Cell Membrane Proteins to Disrupt Melanosome Transfer between Cells 0.58
Building “Leaning Towers” on Living Cell Membrane with Single Artificial Channel Molecules 1.00
1 1.00
Intelligent delivery of autophagy-targeting chimeric peptides by engineered exosomes for the degradation of a-synuclein 1.00
8 7.94
Thiol‐Disulfide Exchange Engineered BSA‐Derived Nanoprodrug for Precise Delivery of Hydropersulfides Against Hepatic Ischemia/Reperfusion Injury 1.00
Rational Construction of Light-Enzyme Hybrid System Driving Interfacial Electrons for Selective Degradation of Bisphenol A: Controlled Immobilization Strategy and Synergistic Catalytic Mechanism 1.00
Bioadhesive Microcryogels Synergize with Therapeutic Ions to Enhance BMSC‐Exosomes Function for Vascularized Bone Regeneration 1.00
Hydrogel Microparticle Encapsulation Enhances In Vivo Peptide Delivery of Recombinant Probiotics 0.94
DNA Nanotechnology‐Engineered Supramolecular Hydrogel Biosensor for Cancer Diagnosis via Extracellular Vesicles 1.00
Aging-Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent Cells 1.00
Nanopore Identification of Nicotinamide Adenine Nucleotide and Its Derivatives 1.00
Neutrophil Membrane‐Engineered Extracellular Vesicles from Perivascular Adipose Tissue‐Derived Stromal Cells for Atherosclerotic Lesion Resolution and Enhanced Vascular Graft Remodeling 1.00
8 7.91
Active Learning Identifies Sulfur‐Based Enhancers for Fe(III)‐Protoporphyrin Catalysis: Recapitulating Features of Natural Oxidase and Beyond 1.00
Calcium-Powered Probiotics Reconfigure the Intestinal Niche via Biofilm Transformation 1.00
Shutting Down the ‘Language Encoder’: A Pathogen-Derived Nano-Interferer Disrupt Sialylation Metabolism and Reprogram Intercellular Communication in Glioblastoma 1.00
A Biomimetic MOF‐Based “Dual‐Stage Cumulative Activation” Autophagic Degradation System to Counter Tumor Recurrence Following Incomplete Radiofrequency Ablation of Hepatocellular Carcinoma 1.00
Biocompatible Nanozyme Shell‐Armed Probiotic with Inflammation Targeting and Scavenging Properties Enables Effective Treatment of Colitis 1.00
A Microalgae‐Probiotic‐Nanozyme Robot for Alleviating Intestinal Inflammation and Microbiota Dysbiosis 1.00
Synergistic Genetic and Chemical Engineering of Probiotics for Enhanced Intestinal Microbiota Regulation and Ulcerative Colitis Treatment 1.00
Materials Evolution by Programmed Twisting: a DNA-Inspired Ultrastrong Supercoiled Conformational Fiber for Energy-Storage and Buffering 0.91
1 0.02
Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies 0.02
2 2.00
Small Ubiquitin-Like Modifier 3 Attenuates Lung Ischemia-Reperfusion Injury Progression by Inhibiting Endoplasmic Reticulum Stress through Heat Shock Protein 70 1.00
AHSA1/Hsp90α complex facilitates microglial mitophagy by targeting TOMM70 in Parkinson's disease 1.00
95 90.65
Multiplexed Peptide-Based Fluorescent Probe Platform for Analysis of HER2-Positive Exosomal Membrane Proteins 1.00
GDAS: A Machine Learning-Driven Approach for the High-Throughput Identification of Disease-Associated Glycoforms 0.85
NP-DiaMS: A High-Throughput Equilibrium Dialysis-LC-MS Platform for Protein-Directed Screening of Natural Products 1.00
Selective Recognition of Tumor-Derived EVs by EpCAM-Imprinted Polymers for Proteomic Biomarker Discovery 1.00
Nanopore Discriminating d‑Glucose Enantiomer Using a Designed Chiral Receptor 1.00
All-in-One Fluorescent Probe: Enabling Simultaneous Tracking of Multiple Dynamic Organellar Perturbations during Ferroptosis 1.00
A Biomimetic Nanozyme Engineered via Coordination and Confinement for Photothermal-Reinforced Catalytic Detection of Extracellular Vesicles and Diagnosis of Cancer 1.00
Genome-Wide Single-Nucleotide Resolution Mapping of DNA Damage by Dual Enzyme Cleavage-Assisted Sequencing 1.00
Discovery of Novel Lactoyl-Metabolites by Integrating Chemical Isotope Labeling and Knowledge-Based Prediction 1.00
A Microchip-Based Gauge for Visual Prediction of Immunotherapy via Distance Readout of Microvesicles 1.00
A Potassium Phosphoramidate-Based Strategy for Compiling and Profiling the Noncanonical N‑Phosphoproteome of Nasopharyngeal Carcinoma 0.89
Polymerase κ Recruits DDX23 To Promote R-Loop Resolution 0.15
Phosphorylated Chemiluminescent Probe Based on Spiro-cyclobutyl-phenoxy-dioxetane for the In Situ Light-Activated Sensing of Alkaline Phosphatase 0.93
Molecularly Imprinted Nanozyme Intelligent Array Sensing Platform Realizes the Enrichment and Quantitative Detection of Small Extracellular Vesicles 1.00
Fluidly Confined CRISPR-Magnetic Microbots Empowered Homogeneous Electrochemical Biosensor for Amplified Detection and Discrimination of Cancer-Derived Extracellular Vesicle Subtypes 1.00
Development of a High-Fidelity EXPAR Platform and Its Application for Ultrasensitive Detection of Diabetic Foot Ulcer-Associated MicroRNAs 1.00
Single-Cell Electrochemical Mass Spectrometry for Complementary Analysis of Cellular Secretions Induced by Mechanical Stimulation 1.00
Label-Free, AI-Driven Evanescent Microscopy Decodes Single-Cell Membrane Protein Binding Kinetics and Adhesion Biomechanics 1.00
A Spatial Coding Strategy for In Situ Visualization of RNA-Specific Glycoforms 1.00
Dual-Affinity HZIF-1Mo Microcolumn Platform for Quantitative Profiling of N-Phosphorylation in Breast Cancer Subtypes 1.00
A Novel Dual Signal Amplification Strategy Integrating APE1-Assisted DNA Walker with Rolling Circle Amplification for Highly Sensitive, Label-Free Exosomal microRNA Analysis 1.00
Enzyme Sandwich of Planar Unsupported Porous Polymer–Lipid Hybrid Bilayer for Single-Molecule Nanopore Enzymology 1.00
Streamlined Digital Microfluidics-Mass Spectrometry Strategy for Extracellular Vesicle Enrichment and Lipid Profiling 0.95
Hitting Two Birds with One Stone: Magnetism–Fluorescence Janus Composites for Simultaneous Targeting of Serum Exosomes and Trapping of Phosphoproteins 1.00
One-Pot O-Glycan Release and Permethylation (OPORP) Enables Rapid and Quantitative O-Glycan Analysis from Low-Input Samples 1.00
An “Enrichment-Detection” Electrochemiluminescence Biosensor Based on Bifunctional Nanozymes for Quantitative Detection of Exosomes with PD-L1 1.00
A Dual-Cascade Activatable Photoacoustic Sensor for Tracking Iron(II) and Reactive Oxygen Species during Ferroptosis 1.00
Intracellular Strand Break End Extension-Encoded Amplification for In Situ Visualization of Diverse DNA Damages 1.00
Triple-Response Peptide Probe for Simultaneous Monitoring the Activity of Three Proteases through a Single Nanopore 1.00
An Allosteric Assay for Identifying Ligands Binding to β2 Adrenergic Receptor by Surface-Enhanced Raman Scattering (SERS)-Active Nanoparticles 1.00
Electric Field-Driven Preparation of a Microdisk Electrochemical Sensor for Revealing Lamellipodium-Mediated Intercellular Communication in Mechanotransduction 1.00
Biomimetic Formation and Tuning of a Cell Surface Heparan Sulfate Network: Approach on Deciphering the Glycosaminoglycans Code 1.00
Characterization of Gas-Phase Charge-Site Isomerism in Flavonoids and Flavonoid Glycosides by Cyclic Ion Mobility-Mass Spectrometry with Computational Validation 0.93
Multistage Cascade-Hierarchical Nucleic Acid Amplification for Label-Free Ultrasensitive Electrochemical Sensing of Tumor-Associated Extracellular Vesicles 1.00
Single Molecular Anchor-Assisted Nanopore Profiling of DNA Abasic Site Reactivity Dynamics 0.89
DSPE-Ti-Chip: A Dual-Functionalized Microfluidic Device for High-Efficiency Isolation of Extracellular Vesicle from Microvolume Biofluids 1.00
Fouling-Proof Nanopore for Detecting Caspase-3 in Complex Biological Fluids 1.00
Near-Infrared Ratiometric Fluorescent Probe for Monitoring Hypochlorous Acid in Ferroptosis Models 0.71
Bimodal Visualization of Mitochondrial Viscosity Remodeling, Morphological Dynamics and Interorganelle Networks in Acute Kidney Injury 1.00
Assessment of Pulmonary Fibrosis and Pleural Invasion in Lung Cancer with Elastin-Targeting Molecular Imaging 1.00
Target-Mediated Assembly of Gold Nanorod Dimers on a Vertically Aligned Gold Nanorod Array for Cooperative Plasmonic Enhanced Fluorescence Detection of Exosomal miRNA 1.00
Quantitative Detection of Serum Protein-Specific Glycosylation in Ovarian Cancer Based on a Signal-Convertible Mass-Tagged Probe Set 1.00
Time-Resolved “Barbecue” Förster Resonance Energy Transfer for Sensitive and Homogenous Detection of Alginate 0.83
Label-Free Probes and Magneto-Thermal Imprinting Enable Rapid Multiplexed Exosomal Profiling for Breast Cancer Classification 1.00
Derivatization-Mediated MALDI-MSI and CE-LIF for Collaborative Analysis of Monosaccharides in Endometrial Cancer Patients: From Pathological Tissues to Serum 1.00
A pH-Responsive DNA Platform for Gentle Enrichment and Efficient Recovery of Extracellular Vesicles 1.00
Ultrasensitive Profiling of Extracellular Vesicles by a Microbead- and Aptamer-Enhanced Thermophoretic Assay for Monitoring Therapeutic Responses 1.00
Sensitive and Specific Analysis of miRNAs in Single Tumor-Derived Extracellular Vesicles Using CRISPR-Based Nanoflow Cytometry 1.00
Deep Learning Model for Fast Determination of Equilibrium Dissociation Constants Using Biolayer Interferometry Sensorgrams 1.00
Label-Free Imaging of Single-Cell Adhesion Using Phase Angle-Responsive Light-Addressable Electrochemical Sensors 1.00
Lipidomic Profiling of Metastatic Lung Cancer-Derived Exosomes Unveiling Ceramides as Potential Biomarkers by Supramolecular Probe Enrichment and Mass Spectrometry Analysis 1.00
Enabling the Identification of Dopamine Receptor Ligands from Complex Matrices Using a Cyclic Tetrapeptide 1.00
Revealing and Distinguishing the Binding Sites of Agonists/Antagonists on the MrgprX2 by CMC-MD Strategy 1.00
Ferroptosis Pathway Discrimination and Anticancer Therapeutic Screening Enabled by Cascade-Activated Fluorescence Reporting of Cysteine-Viscosity Dynamics 1.00
Comprehensive Characterization of Atypical Serum Albumin N-Glycosylation Reveals Hepatocellular Carcinoma Diagnostic Biomarkers 1.00
Highly Sensitive and Specific Detection of Autophagy Signaling Pathway in Live Cancer Cells for Chemoresistance Assessment via ZnO–DNA Nanosphere Probes 1.00
Dopamine-Modulated Highly Oxygen-Vacancy Ce Metal–Organic Frameworks Boost Phosphatase-Catalyzed Chemiluminescence 1.00
Two-Dimensional FAIMS-TIMS Separation for Probing Structural Diversity of Peptides with Resolution Exceeding 6500 1.00
Robust Identification of Gas Mixtures from FTIR Spectra using Attention Mechanism to Mitigate Instrument Line Shape Variations 1.00
Targeted Conversion from the Nucleus to the Nucleolus of Nu-red by Shortening Its Conjugated Chain 1.00
A Pathological Collagen-Targeting Nanozyme Chip for Ultrasensitive Quantification of Collagen in Body Fluids 1.00
Bioinspired Nanofluidic Synapse Capable of Dopamine Sensing with an Inverted-U Dose–Response Function 1.00
Intramolecular Proximity-Induced Amplification for Accurate Imaging of Glycosylated RNAs in Living Cells and Zebrafish 1.00
Development of Tandem Ion Mobility Spectrometry Based on Heat-Induced Dissociation and Its Application in Explosives Detection 1.00
Sensor Arrays Based on Supramolecular Compound Calixarene: Innovative Breakthroughs in the Detection of Tumor-Associated Carbohydrate Antigens 1.00
Novel Copper Superparticle-Based Bragg Scattering Coupling Luminescence Strategy for Detection of Ginseng Exosomal miRNA 1.00
Liquid Crystal Sensor Harnessing a Biomimetic Acetylcholinesterase Nanozyme for Detection of Trypsin in Human Serum 0.75
Super-Resolution Imaging Captures Mitophagy Dynamics: Tricolor Fluorescence Labels Mitochondria, Autophagosomes, and Lysosomes 1.00
Precise Monoisotopic Peak Assignment of Intact Glycopeptides Using Partial Average Mass Matching 1.00
In Situ MicroRNA Profiling of Single Tumor Extracellular Vesicles for Precise Prostate Cancer Diagnosis 1.00
Multicyclic Ligation-Driven Self-Assembly of Magnetic Nanobundles for Sensitive Profiling of Multiple Repair Glycosylases in Cancer Cells 1.00
In Situ Imaging of Extracellular Vesicles and Non-Alcoholic Fatty Liver Disease with a Near-Infrared Fluorescent Viscosity Probe 1.00
O-Glycosylated RNA Identification and Prediction by Solid-Phase Chemoenzymatic TnORNA Method and PONglyRNA Tool 1.00
Amplification-Free Dye-Labeled Digital Immunoassay: From Subpicomolar to Attomolar 1.00
Simple One-Step Deuterated Peracetylation-MALDI-MS/MS (OSDPM) Strategy for Structural Sequencing of Glycosaminoglycan Oligosaccharides 0.30
Array-Based Rapid Identification of Herbal Medicines via a Bifunctional Color-BiLink Strategy 1.00
Adduct-Induced Variability in Tandem Mass Spectrometry 0.33
A Novel Single-Molecule Fluorescence Lifetime Probe for Apoptosis Diagnosis Through Mitochondrial SO2 and DNA Co-Detection 0.78
iMEMQ: Sensitive and Versatile Detection for Extracellular Vesicles via Immunomagnetic EVs’ mRNA qPCR 1.00
Time-Resolved Quantification of Single-Cell Extracellular Vesicles Secretion for Drug Resistance Evaluation 1.00
Pore-Size Confinement Strategy in Hierarchical Porous MOFs for Efficient Enzyme Immobilization and Thiol Identification 1.00
Tuning Microenvironment over Metal–Organic Frameworks for Efficient Enzyme Immobilization and Sensitive Immunoassay 1.00
De Novo Sequencing of Enoxaparin Oligosaccharides through HILIC-Q-cIM-MS: A Strategy for Resolving Complex Glycans 0.95
Nanozyme-Enabled Multimodal Sensing: Visual and Rapid Profiling of Extracellular Vesicles 1.00
High-Throughput Capture and Sensitive In Situ Visualization of Protein N-Phosphorylation on Membranes Based on DpaZn-Nanopolymers Functionalized Reverse Phase N-Phosphoprotein Array 1.00
Glycoproteomics Analysis to Identify Potential Biomarkers and Investigate CD14+ Monocyte Activation Mechanisms via Exosomal Proteins in Cerebral Infarction Using a Novel Glycogen-Functionalized Nanoprobe 1.00
Concentric-Type Immunoblotting for Simultaneous Separation and Detection of Exosomal Proteins 1.00
A Retention-Monitoring Assay Based on Logic Profiling Nucleic Acid Framework for Accurate Identification of Extracellular Vesicles 1.00
Unveiling the Accurate Site-Specific N- and O-Glycosylation of Hyperglycosylated Erythropoietin Drugs by an Integrated Approach 0.75
A Label-Free Method Combining Chromatography Enrichment with N-Terminal Specific Proteolysis Enables Sensitive Identification of Tn/sTn Glycosites 1.00
High-Flux Chip for Sensitive Profiling of Small Extracellular Vesicle Proteins by Cas9/Switch-sgRNA Complex-Mediated Proximity Cleavage Assay 1.00
Accurate Diagnosis of Colorectal Cancer Using a Combination of Lectin-Induced Recombinase Polymerase Amplification and CRISPR/Cas12a Assay on a Point-of-Care Testing Platform with Deep Learning Assistant 1.00
Improved ESI-MS Sensitivity via an Imidazolium Tag (DAPMI-ITag) for Precise Sialic Acid Detection in Human Serum and CMAH-Null Mouse Tissues 0.67
AI-Assisted Native Proteomics: Delineating Ribosomal Protein Conformations Pre- and Post-Assembly 1.00
Tri-Recognition-Mediated Proximity Ligation for Quantitative Analysis of Exosomal Protein-Specific Sialylation and Application on a Microfluidic Platform 1.00
44 40.16
Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation 0.88
A De Novo Chemoenzymatic Assembly Strategy Enables the Efficient Preparation of a Large Core-Xylosylated N-Glycan Library for Probing Antibodies Against Schistosoma japonicum 1.00
A Bioinspired Nanozyme Enables Glycoimmune Therapy via Precision Sialoglycan Trimming 1.00
Anti-CRISPR Protein Regulates CRISPR/Cas12a Fusogenic-Nanovesicle-Based Platform for Extracellular Vesicle-Encapsulated Non-Nucleic Acid Target In-Vesicle Detection 1.00
Supramolecular Assembly of Proteoliposomes Containing Photosensitizers Regulating Energy Synthesis 1.00
Bioinspired Molecular Engineering of IRE1‐Gated DNAzymes for Self‐Adaptive Bidirectional Modulation of ER Stress 1.00
Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance 0.84
Conformation-Adaptive Crown Ether-Polyimides as Superfast and Exceptionally Selective Artificial Na+ Channels 1.00
High‐Performance Artificial Lithium Channel Enabled by a Brominated Organic Imine Cage 1.00
Unanticipated Emergence of the Photo-Switchable Cs+-Selective Ion Channels From One-Dimensional 18-Crown-6 Arrays 1.00
Co‐Confinement of Enzymes and Cofactors Within Pickering Droplet Derived Microreactors for Continuous Flow Catalysis 1.00
Photoconversion of Nitrogen to Ammonia by Peptidophotocatalyst 1.00
Proton‐Activated Artificial Channels for pH‐Selective Cancer Therapy 0.91
Inert Complexes Unlock Ligand‐Accelerated Transition‐Metal Catalysis on Proteins 1.00
Chemoenzymatic Synthesis of Glycopeptide Library Decodes Sialylation-Dependent Immunodominance to Enable a Potent Multicomponent Antitumor Vaccine 1.00
A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids 1.00
Chemoenzymatic Synthesis and Antigenicity Evaluation of an O-Antigen Octadecasaccharide from Helicobacter pylori 1.00
A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering 1.00
Flexible Crown-Ether Polyimides Break the K+/Na+ Selectivity Barrier in Artificial K+ Channels 1.00
From Pharmacophore to Warhead: NAD+-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors 0.03
Flipping of a Non-productive Substrate Binding Conformation Facilitates Hydroxynitrile Lyase Catalyzed Hydrocyanation 1.00
Uphill Anion Transporters with Ultrahigh Efficiency Based on N-Heterocyclic Carbene Metal Complexes 1.00
Reversible Zn2+-Activated Channel Transport Through Monomer-Dimer Interconversion of Rotaxane 1.00
Discovery of a Serine‐Directed Chemical Reaction for Site‐Specific Protein Modification via Phage Display Screening 1.00
Rhodopsin-Mimicking Reversible Photo-Switchable Chloride Channels Based on Azobenzene-Appended Semiaza-Bambusurils for Light-Controlled Ion Transport and Cancer Cell Apoptosis 0.92
A Reversible Chemoenzymatic Labeling Strategy for Profiling of Protein O‐Glucosylation 1.00
Solvent- and Energy-Free Solid-State Strategy for Enzyme Encapsulation in ZIF 0.11
Site-Specific Recognition of Inosine-Modified RNA by Deoxyribozyme with Distant Cleavage Site 1.00
A Chemical Glycoproteomic Approach Decrypts Urinary Extracellular Vesicle Surfaceome for Prostate Cancer Diagnosis and Grading 1.00
Rapaprotin, an Endopeptidase-Activated Proteasome Inhibitor that Induces 26S Disassembly 0.36
Probing and Enhancing DNA Ligase Specificity via Se‐Atom‐Mutagenesis of ATP for Accurate Gene Synthesis and Detection 1.00
A Genetically Encoded Assay System to Quantify O-GlcNAc Transferase (OGT) Activity in Live Cells 0.10
Chirality‐Induced Split Personality in Polymer with Intrinsic Microporosity‐Based Artificial Ion Channels 1.00
A Photothermal Nano‐Switch for Tumor‐Selective Wnt Hyperactivation in Vivo 1.00
A Molecular Staircase Built from Hydrazide-Linked Pyridines as an Artificial Proton Channel 1.00
Programmable Chemoenzymatic Assembly of a Bisected and Core-Fucosylated N-Glycan Library Reveals Glycan-Binding Protein Specificity and Branch Preference 1.00
TASK2-Inspired pH-Gating Polymeric Nanochannels with Multiple Interconvertible Permeability States by Synergistic Regulation of Conformation and Charge 1.00
Dual‐Function Tetrabenzylphosphonium Groups as Mitochondria‐Targeting Artificial Anion Channels 1.00
Enzyme‐Assisted Confined Synthesis of Metal Nanoparticles in Covalent Organic Frameworks for Efficient Enzyme‐Metal Cascade Catalysis 1.00
Localized Hydrolysis‐Based Proximity Reporting Platform for Protein Hierarchical Structure Profiling 1.00
Fulcrum Occupancy–Leverage Perturbation Strategy Enables Rapid Discovery of Potent CDK2–Cyclin A2 Interaction Inhibitors 1.00
Identification of Isomerically Diverse Ginsenosides Using Engineered Aerolysin Nanopore via Non‐Translocation Blockade Sensing 1.00
Triadic Electrophilic Centers Specifically Bind to SMO Transmembrane Domain to Inhibit the Hedgehog Pathway 1.00
An All-in-One Nanohole Array for Size-Exclusive Trapping and High-Throughput Digital Counting of Single Extracellular Vesicles for Non-Invasive Cancer Screening 1.00
2 1.05
Proteasome subunit PSMD1 is a key therapeutic target in multiple myeloma 0.05
Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis 1.00
2 2.00
Translation of GGC repeats into a toxic polyglycine protein in oculopharyngodistal myopathy type 2 1.00
Intronic VNTRs downregulate expression of iHSF1/i and confer genetic risk of essential tremor 1.00
5 4.91
Drp1 Interaction with BIP Maintains Mitochondrial Dynamic Equilibrium to Promote Anoikis Resistance and Metastasis in Nasopharyngeal Carcinoma 1.00
Targeting Sialylation Enhances the Therapeutic Efficacy of the Nectin-4-Targeted Antibody-Drug Conjugate Enfortumab Vedotin in Bladder Cancer. 1.00
Extracellular Vesicle-Packaged miR-99a Reprograms Fibroblasts to Create an Inflammatory Niche that Drives Colorectal Cancer Metastasis. 0.95
Hypoxia-Induced Creatine Uptake Reprograms Metabolism to Antagonize PARP1-Mediated Cell Death and Facilitate Tumor Progression in Hepatocellular Carcinoma. 1.00
BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells 0.96
7 6.02
Structural basis of Wnt signalosome extracellular complex assembly 1.00
Engineered commensals for metabolic modulation of the gut-liver-brain axis 0.02
NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis 1.00
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator 1.00
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment 1.00
Protein restriction reprograms the multi-organ proteomic landscape of mouse aging 1.00
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures 1.00
1 0.95
Exploring functional insights into the human gut microbiome via the structural proteome 0.95
5 5.00
Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis 1.00
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation 1.00
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis 1.00
Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate 1.00
RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation 1.00
2 1.88
Smooth muscle cells transiently acquire a CD34+ progenitor state upon injury to drive pathological vascular remodeling 1.00
IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner 0.88
8 8.00
Silicon rhodamine-based fluorescent probes for monitoring mitochondrial viscosity dynamics during mitophagy 1.00
Site-specific N-glycoproteomic analysis of four M2 macrophage subtypes derived from human THP-1 cells 1.00
A novel method for Tn antigen detection based on chemoenzymatic targeted labelling and CuAAC click chemistry 1.00
OaAEP1-dependent enzymatic protein ligation and immobilization for single-molecule force spectroscopy 1.00
Enhanced-sensitivity profiling of natural products from TLC plates using a facile graphite-based LA-DART-MS platform 1.00
Molecular machines for transmembrane ion transport 1.00
Chiral polymer dots for ratiometric enantioselective monitoring of d-cysteine in the brains of Alzheimer's disease mice 1.00
Restructuring of mortise-and-tenon frameworks at the molecular level 1.00
18 16.01
Enzymatically hydrolyzed oligosaccharide fingerprinting using nanopipettes at the single-molecule level 1.00
Foldamer-based K+ channels with ion selectivity surpassing the KcsA channel 1.00
Deep profiling reveals coordinated remodeling of ganglioside metabolism in MCF-7 breast cancer cell line 1.00
Functionalized two-dimensional nanochannel membranes to distinguish methylated/unmethylated peptides for sensing cellular G9a protein 1.00
Single-position ligand modifications tune CB2R activity by targeting the toggle switch 0.13
Molecular basis for the biosynthetic divergence of anthracyclines kosinostatin and chartreusin 1.00
DSSA-PPI: enhancing binding affinity change prediction upon protein mutations using disentangled structure–sequence aware attention 1.00
Protein-encapsulated fluorogenic probes for the selective detection of endogenous O-GlcNAcase (OGA) 0.93
Unlocking the application potential of AlphaFold3-like approaches in virtual screening 1.00
Hydrogen-bond-assisted meta-nitrogen-doped graphyne enables real-time electrocatalytic NADH tracking in single cells 1.00
Fast-switching pH-responsive biomimetic ion channels with bidirectional gating control 1.00
Design and optimization of caspase-1-responsive fluorescent probes for pyroptosis imaging and anti-pyroptosis drug screening 0.88
SAGERank: inductive learning of protein–protein interaction from antibody–antigen recognition 1.00
Wavelength dependent photochemistry of an iron dinitrogen hydride complex ivia/i multiple spectroscopies – competing ejection of axial ligands 0.08
Helical foldamers replicating membrane-spanning gramicidin a with pH responsiveness and ultrafast potassium permeability 1.00
Unifying sequence-structure coding for advanced protein engineering via a multimodal diffusion transformer 1.00
GlycanInsight: an open platform for carbohydrate-binding pocket prediction and characterization 1.00
Construction of the reduced nicotinamide adenine dinucleotide salvage pathway in artificial cells and its application in amino acid synthesis 1.00
4 4.00
P16+ Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated Recruitment of Cytotoxic Lymphocytes. 1.00
Mitochondrial Tumor Suppressor 1A Attenuates Myocardial Infarction Injury by Maintaining the Coupling Between Mitochondria and Endoplasmic Reticulum 1.00
Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis. 1.00
FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1 1.00
4 3.42
Mechanoregulation of basal body integrity during Plasmodium exflagellation 1.00
Phosphorylation of the α subunit inhibits proteasome assembly and regulates cell cycle in an archaeon 1.00
TRPM-mediated mechanoreception regulates myosin oscillation during tissue elongation 1.00
Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere 0.42
4 2.83
Mitogen-activated kinase 6 facilitates autophagy initiation to confer salt tolerance in maize 0.83
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants 0.06
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging 0.94
TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi-selective autophagy 1.00
1 1.00
Melatonin alleviates UV-induced embryonic toxicity via PARP1 expression in early mouse embryos 1.00
1 0.93
Sulfidation Unlocks Dual Reductive Pathways in Uranium Immobilization by Iron Sulfide 0.93
2 2.00
Senescence-associated metabolic alterations aggravate calcific aortic valve disease 1.00
Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction 1.00
1 0.30
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3 0.30
2 1.96
Balancing gene ontology annotation specificity in protein function prediction based on the protein sequence large graph 1.00
Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations 0.96
1 1.00
The effect of iron sulfidation on the stability of the trisulfur radical ion S3•‾ in subduction zone fluids 1.00
4 3.93
Circulating extracellular vesicle long RNA profiling combined with machine learning unveils novel diagnostic signature and molecular features in chronic pancreatitis 1.00
SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL 0.93
Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α–IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers 1.00
Galectin-4 drives anti-PD-L1/BVZ resistance by regulating metabolic adaptation and tumour-associated neutrophils in hepatocellular carcinoma 1.00
1 1.00
Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence 1.00
5 4.20
Mechanism of Peroxide-Dependent Heme-Lysine Cross-Link Formation in Cytochrome P460 from N. europaea: Cpd I-Triggered meso-Carbon Hydroxylation and C–N Bond Formation 1.00
Reduction of Nitrite to NO on a Molybdenum–Thiolate Platform and Protonation of the Anionic Nitrosyl Complex 1.00
Rosmarinic Acid Is an hCtr1 Inhibitor that Interferes with Copper Transport Activity 1.00
Evaluation of NaCl-KCl-Al2S3 Molten Salts by Raman Spectroscopy and Quantum Chemical Calculations 1.00
Reduction of Hexaazatrinaphthylenes by Masked Divalent Lanthanide Dinitrogen Reagents 0.20
1 1.00
Genetic insights into socioeconomic inequalities and adiposity-related interventions for reducing accelerated biological aging 1.00
31 26.54
Hexosamine biosynthesis drives hemocyanin O-GlcNAcylation to potentiate antibacterial immunity in shrimp 0.94
Starvation-induced HSC70 O-GlcNAcylation activates chaperone-mediated autophagy 1.00
Fungal oxidative stress tolerance depends on peroxiredoxin PrxA-mediated redox signaling to mitochondrial cytochrome c peroxidase Ccp1 0.94
Electrostatic tuning of the pyridoxal-5′-phosphate cofactor site defines pH dependence in type I cystathionine β-lyases 0.96
A dileucine motif in TMEM163 is essential for its binding with both AP-3 and BLOC-1 complex 1.00
BARD1 recognizes pre-rRNA for DNA damage repair and rRNA biogenesis 1.00
Structural basis of EGF-repeat O-glucosylation by the protein O-glucosyltransferase POGLUT2 1.00
Structure of Acinetobacter baumannii cytochrome bo3 ubiquinol oxidase 1.00
The AAA-ATPase Yta4 inhibits the interaction between Ppa2 and Atg43 to promote Atg43 phosphorylation and mitophagy 1.00
HuR-Driven Reversible Mitochondrial Shuttling Buffers Cytosolic miRNA Levels in Hepatic Cells 0.17
Alix Mediated Selective Packaging of β-Catenin into Extracellular Vesicles Enhances Their Pro-Angiogenic Function 1.00
Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice 0.05
Andrographolide targets Syndecan4 to impair its interaction with Syntenin and inhibits the biogenesis of small extracellular vesicles 1.00
SIRT7 safeguards ERα proteostasis via deacetylation-dependent degradation of unliganded and misfolded receptors 1.00
GRIA1 regulates TGN export and secretion of Sonic hedgehog 1.00
The role of DNAJC3 in enhancing glioma progression and regulating the tumor immune microenvironment 1.00
Oligomerization is Required for Channel Formation of MctB and for Copper Resistance of Mycobacterium tuberculosis 0.25
Phosphatidylcholine coordinates ER-autonomous and ER-nonautonomous adaptations to unfolded protein response dysfunction 1.00
RPL35A drives aerobic glycolysis and tumorigenesis by facilitating MYC-mediated SKP2 transcription 1.00
Selective Peptide-Guided Transcytosis Enhances Extracellular Vesicle-Mediated siRNA Delivery Across the Blood-Brain Barrier. 1.00
The DID of CAPS-1 anchors plasma membrane to promote vesicle exocytosis 1.00
ZBP1 Orchestrates Dynamic Transitions Between Cell Death Pathways in Response to Arsenic and Hyperosmotic Stress 0.91
The RING-finger domain of Arabidopsis RMR functions as an E3 ligase essential for post-Golgi trafficking 1.00
Nucleolar protein DCAF13 promotes non–small cell lung cancer cell proliferation via facilitating rDNA transcription and ribosome biogenesis 1.00
REIIBP methylates nucleolar proteins and regulates pre-rRNA processing 1.00
Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex 0.20
PERK and IRE1α promote exosome secretion via blocking lysosomal degradation of multiple vesicular body 1.00
Acetylation of microtubule-binding PinX1 orchestrates ribosome biogenesis to nutrient starvation via the RNA polymerase I preinitiation complex 1.00
The Poly(A) Polymerase Star-PAP is Regulated by Stably Associated Phosphoinositide Messengers 0.13
Rag GTPases control lysosomal acidification by regulating v-ATPase assembly in Drosophila 1.00
Molecular mechanism of antagonist recognition and regulation of the α1A-adrenoceptor 1.00
9 7.88
Linker extension impairs ESCRT-III flat spirals and the mediated membrane abscission 1.00
Plasma membrane-to-lysosome FGR signaling regulates endocytosis-associated lysosome homeostasis 1.00
CRM1 inhibits NPAT condensation and histone locus body formation via a competitive occupation strategy 1.00
Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis 1.00
TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion 1.00
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb 0.97
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from Golgi to cell surface 1.00
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex 0.11
The autophagy protein ATG-9 regulates lysosome function and integrity 0.80
3 2.96
Magnetic biochar-immobilized enzymatic systems for bioremediation of penicillin G sodium in antibiotic-laden fermentation residues: Removal efficiency, degradation mechanism, and ecological safety 0.96
Sustainable biomanufacturing of food proteins enabled by economical SCXG-MiXBM affinity system 1.00
Research on enhancing the expression and immobilization of oxalate decarboxylase via the bicistronic translation coupling strategy 1.00
2 1.95
Vascular smooth muscle cell-derived KIF13B protects against atherosclerosis: evidence from humans and mice 1.00
Vinculin influences essential processes in enteric nervous system development and Hirschsprung disease pathogenesis 0.95
1 0.07
Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss 0.07
1 1.00
Tearing down the wall: emu-miR-745-3p in Echinococcus multilocularis exosomes attenuates host liver fibrosis to permit invasive lesion development 1.00
3 2.28
Cochlear Amplification Modulates Synaptic Transmission at the Endbulb of Held Synapse in the Cochlear Nucleus 1.00
ATP release deficiency through astrocytic connexin 43 in the dorsal hippocampus promotes depressive- and anxiety-like behaviors 1.00
High-pressure freezing EM tomography of entire ribbon synapses in the retina 0.28
1 1.00
The deletion of HSP60 in cholinergic neurons alleviates LPS‐induced depressive‐like behaviours in mice by reducing neuroinflammation 1.00
43 36.84
De Novo Design of Miniature and Efficient Metallo-Ketoreductases 0.71
Nanosensor Quantifying Lysosomal Glycosidase Secretion from Single Living Cells 1.00
Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists 0.21
Discovery and Enzymatic Regulation of Lysine Fumarylation, a Post-Translational Modification in Bacteria 1.00
A Single-Vesicle Electroanalytical Approach Uncovers Deficits of Vesicular Acetylcholine Content in Alzheimer’s Disease 1.00
Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity Switching 1.00
Nanopore-Based Glycan Sequencing via a Fragmentation-Reassembly Strategy 1.00
HAAC Ligation-Enabled Hierarchical Assembly: Deciphering the Synergy of α-Hydroxyl Aldehydes and 2-Aminooxazoles 1.00
Single-Feature Identification of α2–8 Linked Sialoglycans Using Engineered Aerolysin Nanopores: A Paradigm for Glycan Linkage Analysis 1.00
A Photoactivatable Glycoenzyme Platform for Spatiotemporally Controlled, Protein-Selective, and In Vivo Glycan Editing 1.00
Supramolecular Polymers Controlled by Glycan Geometry 1.00
Early Ferroptosis Detection Targeting Lipid Hydrogen Abstraction 1.00
T-Cell “Rejuvenation” Nanovaccine: Enhancing Immunological Memory and Antitumor Responses through Telomere Extension 1.00
Measuring Sodium Transport in Cells with Nuclear Magnetic Resonance 1.00
Cancer Metastasis Blockage by Exosome-Neutrophil Nanocoupler 1.00
MetalloDock: Decoding Metalloprotein–Ligand Interactions via Physics-Aware Deep Learning for Metalloprotein Drug Discovery 1.00
A Tumor-Selective Self-Assembling Network of Poly(amino acid) Induces Cascading Bystander Cytotoxicity through Microvesicle Fission Amplification 1.00
Genetic Code Expansion in Probiotics Enables the Secretion of Covalent Protein Drugs in Mice 1.00
Biophysical-to-DNA Catalytic Cumulative Birecorder for Measuring Continuous Membrane Fluidity 1.00
Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs 0.17
Mismatched Nucleotide Rejections at the Open and Ajar States of DNA Polymerase I Ensure High Fidelity 1.00
Structural and Mechanistic Insights into Bacterial Hydrazine Biosynthesis 1.00
Disruption of β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Using Heterogeneous Peptidomimetic Foldamers 0.80
Conversion of a Heme-Dependent Dehydratase to a Piperazate Synthase Reveals the Role of the Heme Propionate Group in N–N Bond-Formation 0.33
Multivalency Enables Signal Processing at Single Protein Level 1.00
Synergistic Programming of Macrophages by Hybrid Glycocalyx-Inspired Nanoparticles for Adoptive Cell Therapy 1.00
Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines 1.00
De Novo Chemoenzymatic Assembly of Complex Sulfated N-Glycans to Comprehensively Profile the Ligand Binding of Human Siglecs 1.00
Real-Space Quantitative Molecular Analysis at Single-Molecule Resolution 1.00
Cyclization Decoded: Engineering Amylomaltase for Efficient α-Glucan Transformations 0.79
Ultrafast Tyrosinase-Mediated Biotinylation of Living Cell Surface Analysis Reveals Novel Cell Surface Proteins Responsible for Influenza A Virus Entry 1.00
Tailoring Artificial Hydration Microenvironments in Covalent Organic Frameworks for Enhanced Enzymatic Catalysis in Organic Media 1.00
Photochemistry of Sulfur Dioxide Mediated by Charge Transfer through Intermolecular Chalcogen Bonds 0.70
An Anaerobic Biomimetic Metal-Free AIE Polymersome Nanozyme as NADH Oxidase Mimic for Photocatalytic Tumor Suppression by Impairing Cancer Cell Energy Metabolism under Hypoxia 0.40
Preorganized Internal Electric Field Enables Nucleophilic Attack of a Nonactivated Water Molecule in Thymine DNA Glycosylase 1.00
Conformational Selection Mechanism of Rhomboid-Catalyzed Intramembrane Proteolysis Revealed by Solid-State NMR 1.00
Spike Signals and MD Simulations Reveal the Significance of Peptide Stretching in Nanopore Protein Sequencing 1.00
Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a “Snap-through” Instability 0.27
Single-Molecule Macrocyclic Carrier Overcomes the Direct Transmembrane of Medium-Sized Cargoes 1.00
Oxaborole-Functionalized Sialylated Glycan Probe for High-Fidelity Fluorescence Imaging of Cancer Tissue 0.20
Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications 1.00
Spatial Configuration-Guided Design of Covalent Organic Framework-Based Artificial Metalloantioxidases for Inhibiting Inflammatory Cascades and Regulating Bone Homeostasis 0.97
A Designed Zn2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases 0.29
1 0.93
Social Engagement and Epigenetic Age Acceleration in the Health and Retirement Study 0.93
3 2.68
Nociceptive sensory nerves induce an IL4Rαhi anti-inflammatory macrophage subset that protects against kidney ischemia-reperfusion injury 1.00
Absence of glomerular IgA1 deposition despite overexpression of galactose-deficient IgA1 in the B cell c1galt1 knockout mouse 0.79
UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis 0.90
5 4.61
Accelerated and Controlled Polymerization of N-Carboxyanhydrides in the Presence of Tertiary Amines with Minimized Activated Monomer Mechanism 1.00
Charge Inversion of Single-Stranded DNA under High-Concentration Monovalent Salts 1.00
Encapsulation of Enzymes in Metal–Organic Frameworks with Dual Thermal Protection for Melt Processing of Self-Biodegradable Plastics 0.86
Facile and Controlled Synthesis of Poly(ethylene glycol)-Polypeptide in an Acidic, Biphasic System 0.75
One-Step Synthesis of Statistical Copolymers Containing Peptide, Ester, Ether, and Amine Linkages via iN/i-Substituted Glycine iN/i-Carboxyanhydrides and Epoxides 1.00
10 8.63
Mitochondrial translation elongation controls OXPHOS biogenesis by coordinating synthesis and folding of mitochondrially encoded proteins 0.71
Multivalent 28S rRNA expansion segments enable reconstitution of multilayered nucleolar architecture 1.00
Mechanosensory channels mediate ER Ca2+ transients to trigger assembly of autophagosome initiation sites for degradation of ER subdomains 1.00
The Erlin1/2 complex is a dynamic scaffold for membrane microdomain assembly on the endoplasmic reticulum 1.00
Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression 0.71
Structural characterization of five functional states of metabotropic glutamate receptor 8 0.92
KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1 0.50
The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress 0.90
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma 1.00
YTHDF1 differentiates the contributing roles of mTORC1 in aging 0.89
3 2.00
Astrocytic connexin 43 hemichannel dysregulation drives prefrontal circuit dysfunction and schizophrenia-like behaviors 1.00
Pyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer’s disease models 0.05
Ganglioside sialylation modulates tau internalization and pathology spread 0.95
6 5.29
Nanopore Analysis of Malto-oligosaccharides from Amylose, Amylopectin, and Cyclodextrin Hydrolysates 1.00
Integrated Chemical Array and SERS Profiling of Plasma Small Extracellular Vesicles for Breast Cancer Diagnosis 0.29
Orthogonal Coding-Guided Liposomal Nanoreactor for One-Pot Precise Proteomic Profiling of Tumor-Derived Extracellular Vesicle Subpopulations 1.00
Activatable and Renal Metabolizable NIR-II Emissive Au Nanoprobe for Real-Time Monitoring of Kidney GSH 1.00
A Dual Recognition-Enabled Amplification (DREAM) Strategy Based on Proximity Ligation-Mediated DNA Cascade Circuit for Extracellular Vesicle Detection and Cancer Diagnosis 1.00
Ultrasensitive Profiling of Plasma Extracellular Vesicles for Breast Cancer Subtyping with a High-Curvature Antifouling Nanoarray 1.00
11 7.35
β-Arrestin condensates regulate G-protein-coupled receptor function 0.38
De novo design of miniproteins targeting GPCRs 0.03
Steric hindrance of antibody binding in an Omicron spike fusion intermediate 1.00
De novo design of GPCR exoframe modulators 1.00
Structures of Ostα/β reveal a unique fold and bile acid transport mechanism 1.00
-Methylpseudouridine directly modulates translation dynamics 0.05
ZAK activation at the collided ribosome 0.09
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy 1.00
Pre-rRNA spatial distribution and functional organization of the nucleolus 1.00
RNA codon expansion via programmable pseudouridine editing and decoding 1.00
NINJ1 regulates plasma membrane fragility under mechanical strain 0.80
4 3.60
Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease 1.00
Democratizing protein language model training, sharing and collaboration 0.73
A trimodal protein language model enables advanced protein searches 0.92
Scalable secondary metabolite production in Streptomyces using a plug-and-play system 0.95
8 7.95
A transport-independent role for SLC25A12 in mitochondrial stress signalling 1.00
Epigenetic programming by H3K23ac defines lineage fate of Meg3+ haematopoietic stem cells and drives immune ageing 1.00
Stress granules restrain ferroptosis by sequestering ferritin 0.97
Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability 1.00
TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy 1.00
DNA nanodevices detect an acidic nanolayer on the lysosomal surface 0.98
MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains 1.00
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection 1.00
13 9.95
Trafficking of a nitrogenase FeMo-cofactor assembly intermediate 0.10
Designing chemigenetic DNA nanotrap for norepinephrine dynamic imaging in organelles 1.00
A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 0.29
Adhesion GPCR-induced ectocytosis mediates intercellular GPCR signal propagation 0.86
Uncovering bacterial pseudaminylation with pan-specific antibody tools 0.06
Structural basis for the catalytic mechanism of human lipid phosphate phosphatases 1.00
Photo-cross-linking-assisted deorphanization deciphers GPR50–L-LEN pairing in metabolism 1.00
A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy 1.00
Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage 1.00
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis 0.70
SARM1 activation promotes axonal degeneration via a two-step phase transition 1.00
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1 0.95
Protein β--glucosylation by LtpM through short consensus sequons G-T/S and S-G 1.00
3 2.92
Recoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids 1.00
Computational design of superstable proteins through maximized hydrogen bonding 1.00
Pseudokinases can catalyse peptide cyclization through thioether crosslinking 0.92
196 165.72
Improving protein and protein interactions using pseudo-dimers derived from monomeric proteins 0.75
Cryo-EM Structure of the TRPC1/5 Heteromer Enables Design of Antidepressant and Anxiolytic Drug with Reduced Side Effects 1.00
Amino acid-based biological age clock and its implications for human health and aging 0.94
Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in mice 1.00
DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes 1.00
EMReady2: improvement of cryo-EM and cryo-ET maps by local quality-aware deep learning with Mamba 1.00
Perivascular adipose single-cell atlas identifies CD55+ adipose-derived stem cells as vascular remodeling regulators in atherosclerosis 1.00
Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease 1.00
Identification and quantification of intracellular N-acetylglucosamine modified glycoRNAs 1.00
Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa 1.00
Subtype-dependent arrestin engagement of the metabotropic glutamate receptors 1.00
Structural basis for positive allosteric regulation of CB2 receptor 1.00
MXene membrane with directionally functionalized channel entrances for enhanced ion selectivity and permeability 0.80
CCDC120 phase separation contributes to desmosomal integrity and cardiac function 1.00
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke 1.00
Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging 1.00
Acetylation of STX17 promotes its autophagosomal translocation 1.00
Creating highly active fluoroacetate dehalogenases via gate-based synergetic chain design 1.00
Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles 0.04
Mining of natural diversity enables efficient and expressible peptide asparaginyl ligases 0.86
Core conformation of arrestin coupling to parathyroid hormone type 1 receptor 1.00
An atlas of human siglecs integrates expression, affinity, and cis/trans sialoglycan recognition profiles 0.13
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors 0.23
Loss of DNA methyltransferase 3a enhances Caspase-8 transcription and promotes cardiomyocyte pyroptosis during myocardial infarction 1.00
Transplantation of active mitochondria condensed in liquid–liquid phase-separated hydrogels ameliorates myocardial ischemia-reperfusion injury 1.00
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging 0.12
Agonal cell resuscitation strategy to promote tissue repair 1.00
MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes 1.00
PGC-derived migrasomes couple PGC proliferation with migration 1.00
Increased WNT10B/FOXO6 signaling promotes cell fate transition in renal tubular cells to aggravate renal inflammation and fibrosis 1.00
Steric hindrance-mediated extracellular vesicle size fractionation for rapid prehospital diagnosis of intracerebral hemorrhage 1.00
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis 0.04
Dynamic monomer-dimer transition in ligand-induced apelin receptor activation 1.00
Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms 1.00
Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast 1.00
Lipid turnover and GEF recruitment collectively determine Rab5 recruitment and activation during the first step of early endosome formation 1.00
Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination 0.96
Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover 1.00
Amplifying metabolic profiling of extracellular vesicle dynamics with ACTIVITY 0.83
Ceramide disrupts TM9SF2-PGK1 axis to redirect PD-L1 trafficking and enhance antitumor immunity 0.94
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers 0.43
Atlas of predicted protein complex structures across kingdoms 0.99
GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis 0.08
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy 0.96
Functional and structural basis of a negative allostery within GABA hetero-tetramers 0.89
Parkinson’s disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer 0.86
StrucGAP: a modular, streamlined and traceable data mining platform for structural and site-specific glycoproteomics 1.00
Functional protein design and enhancement with ontology reinforcement iteration 1.00
Calcium-mediated calreticulin-IRE1α interaction drives dynamic fluctuation of IRE1α activity under chronic endoplasmic reticulum stress 1.00
A model for drug transport across two membranes of Gram-negative bacteria by an MFS tripartite assembly 0.82
Structural basis and regulation of GSDME pore formation 0.19
The COP1-ADA2b module mediates light regulation of DNA double-strand break repair in Arabidopsis 1.00
Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells 0.07
Extracellular vesicle engineering using a small scaffold protein 1.00
Structural and mechanistic insights into the dual-nuclease defense protein Upx as an anti-phage system 1.00
Accelerated discovery of highly active enzyme nanohybrids with parallelized Bayesian optimization in hybrid space 1.00
TIGAR regulates intestinal mucus barrier integrity by inhibiting lactylation of G6PD/6PGD in ulcerative colitis 1.00
Rab14 restricts pathogens by promoting V-ATPase lysosomal delivery to drive lysosomal acidification 1.00
Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT 0.50
DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence 1.00
Harnessing a germ‑free mouse gut bioreactor for directed evolution of probiotics to combat non-alcoholic fatty liver disease 0.90
Engineering LmrR protein for L-proline-based asymmetric aldol biocatalysis 1.00
A protein adaptor mediating Ap4A-dependent control of protein acetylation 0.11
Molecular insights into fungal inositol phosphorylceramide synthesis and its inhibition by antifungal aureobasidin A 1.00
An equivariant pretrained transformer for unified 3D molecular representation learning 0.96
Interpretable and generative deep learning models explicate phase separating intrinsically disordered motifs 1.00
Molecular mechanisms of flotillin complexes in organizing membrane microdomains 1.00
Molecular basis of collagen galactosylation by GLT25D1 1.00
FGF 13 functions as a regulator of the ERK/aerobic glycolysis axis in the inflammatory state during septic lung injury 1.00
The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition 0.06
TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience 0.22
Large-scale serum glycomics tracks -glycosylation dynamics in hepatocellular carcinoma progression and enables early diagnosis 1.00
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis 0.10
Tmem110 regulates the conformation of TRPML1 to maintain endolysosomal homeostasis and prevent mitochondrial DNA leakage and pathological self-DNA processing 0.82
A comprehensive -glycoproteome atlas reveals tissue-specific glycan remodeling but non-random structural microheterogeneities 1.00
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling 1.00
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis 0.50
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program 1.00
-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release 0.89
Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management 1.00
Measuring and locating the changes in protein structure using MELO 1.00
Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature 0.78
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling 1.00
Leveraging engineered mitochondria through intercellular communication network for accelerated transport and delivery 1.00
Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins 1.00
Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections 1.00
Molecular insights into ligand recognition and signaling of OXGR1 1.00
Calcium-sensitive synaptotagmin 11-lipid interaction modulates exo-endocytosis 1.00
Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus 1.00
ARMH4 accelerates aging by maintaining a positive-feedback growth signaling circuit 1.00
Activation of the RSAD2-YTHDF1 axis in smooth muscle causes inflammatory bowel disease via intercellular mitochondrial transfer 1.00
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity 0.93
A novel long-galanin peptide from non-mammalian vertebrates mitigates the inflammatory response in IBD models via the biased GALR2/β-arrestin2 pathway 0.94
Sodium disrupts mitochondrial energy metabolism to execute NECSO 1.00
Conversion of N2 into oxadiazoles promoted by a multinuclear samarium complex 1.00
NRF1-mediated innate immune response drives inflammaging 1.00
Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis 0.03
Revealing the genetic architectures underlying organ-specific aging based on proteomic data 1.00
Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis 1.00
Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity 0.97
Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139 0.16
Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control 1.00
Bone homeostasis regulation by in vivo generation of osteoclast-derived apoptotic bodies using targeted self-assembly 1.00
Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+ 1.00
Benchmarking all-atom biomolecular structure prediction with FoldBench 1.00
Molecular insights into species-specific ACE2 recognition of coronavirus HKU5 1.00
USP16 S-nitrosylation aggravates coronary microembolization-induced myocardial injury via repressing KDM1A-mediated glutathione homeostasis 1.00
Understanding interspecies drug response variations between human and rodent P2X7 receptors 1.00
Tuneable ion selectivity in vermiculite membranes intercalated with unexchangeable ions 0.68
Mechanical confinement induces ferroptosis through mitochondrial dysfunction 0.75
In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity 1.00
Structural basis of menaquinone reduction by succinate dehydrogenase from Chloroflexus aurantiacus 1.00
Ab-initio amino acid sequence design from protein text description with ProtDAT 1.00
Investigating the neuronal role of the proteasomal ATPase subunit gene in neurodevelopmental proteasomopathies 0.01
Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells 1.00
mRNABERT: advancing mRNA sequence design with a universal language model and comprehensive dataset 1.00
High-accuracy protein complex structure modeling based on sequence-derived structure complementarity 1.00
Enhancing functional proteins through multimodal inverse folding with ABACUS-T 1.00
RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis 1.00
A mitochondria-targeted fluoropolymer nanoparticle with inherent mitophagy-inducing and red fluorescence properties for treatment of atherosclerosis 1.00
GABA-independent activation of GABAB receptor by mechanical forces 0.76
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80 1.00
Structural insights into antagonist recognition by the vasopressin V2 receptor 1.00
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging 0.91
A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly 1.00
Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer 0.98
Correlative voltage imaging and cryo-electron tomography bridge neuronal activity and molecular structure 0.08
Structural mechanism of the agonist binding on human TRPC3 channel 1.00
Cetacean loss of the master adipose tissue regulator β3-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal 1.00
A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis 1.00
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes 1.00
ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis 1.00
Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins 1.00
Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation 0.92
Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration 1.00
Sensitive, high-throughput, metabolic analysis by molecular sensors on the membrane surface of mother yeast cells 0.80
Dynamic rigidity changes enable rapid cell migration on soft substrates 1.00
MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap 0.05
Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid 1.00
A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli 0.89
The shutdown of food digestion due to endoplasmic reticulum homeostasis disruption acts as a protective mechanism in C. elegans 1.00
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor 0.02
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank 0.06
A reconfigurable piezo-ionotropic polymer membrane for sustainable multi-resonance acoustic sensing 0.35
Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice 1.00
Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation 1.00
Mechanism and function of GPR3 regulated by a negative allosteric modulator 0.40
Remodeling adipocytes’ lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow 1.00
Dual mitotic bookmarking by GAF and H3K27ac orchestrates differential propagation of cell fate memory in neural development 1.00
Fishing out AIEC with FimH capturing microgels for inflammatory bowel disease treatment 1.00
The cAMP-PKA signaling initiates mitosis by phosphorylating Bora 1.00
Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores 0.20
Molecular insights of acarbose metabolization catalyzed by acarbose-preferred glucosidase 1.00
Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection 1.00
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury 1.00
LABind: identifying protein binding ligand-aware sites via learning interactions between ligand and protein 1.00
A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids 1.00
A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses 0.78
Single extracellular vesicle imaging via rolling circle amplification–expansion microscopy 0.86
Translational fidelity and longevity are genetically linked 1.00
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk 1.00
Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex 1.00
SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse 0.06
A covalent organic framework membrane with highly selective and permeable artificial sodium channels via ion recognition 0.67
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules 0.90
Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI 1.00
Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions 0.86
Development and application of GlycanDIA workflow for glycomic analysis 0.11
A controllable photoresponsive potassium transporter 1.00
Sequence-based virtual screening using transformers 0.21
Comprehensive profiling of the catalytic conformations of human Guanylate kinase 1.00
Age mosaic of gut epithelial cells prevents aging 1.00
A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses 1.00
Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids 1.00
Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control 1.00
Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification 1.00
Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors 1.00
Gip1 GPCR regulates two sexual-stage differentiation processes in the ascomycete 0.91
Rab27a regulates the transport of influenza virus membrane proteins to the plasma membrane 1.00
EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress 1.00
Harnessing protein language model for structure-based discovery of highly efficient and robust PET hydrolases 1.00
DSS1 is required for proper Integrator–PP2A function 1.00
Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia 1.00
A multicellular star-shaped actin network underpins epithelial organization and connectivity 0.05
Nanostructured organic sheets sequestering small extracellular vesicles and reactive species to protect against radiation-induced mucositis 0.85
An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity 1.00
DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation 0.92
Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases 1.00
Molecular architecture and catalytic mechanism of human glycogen debranching enzyme 1.00
Biomimetic synthesis of vesicular covalent organic frameworks by gemini surfactants for in-situ enzyme cascade immobilization 1.00
Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation 0.92
Cooperative and inhibitory ion transport in functionalized angstrom-scale two-dimensional channels 0.03
Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation 1.00
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells 0.94
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates 1.00
ROMO1 overexpression protects the mitochondrial cysteinome from oxidations in aging 1.00
1 1.00
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response 1.00
1 0.00
The exposome of brain aging across 34 countries 0.00
3 3.00
A comprehensive foundation model for cryo-EM image processing 1.00
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques 1.00
Integrating diverse experimental information to assist protein complex structure prediction by GRASP 1.00
2 1.98
Spatiotemporal-adaptive nanotherapeutics promote post-injury regeneration in ageing through metabolic modulation 1.00
An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing 0.98
2 0.78
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease 0.14
Munc18 modulates syntaxin phase separation to promote exocytosis 0.64
1 1.00
Electrochemically modulated interferometric scattering microscopy for imaging ion channel activity in live cells 1.00
1 1.00
Decoding frequency-modulated signals increases information entropy in bacterial second messenger networks 1.00
5 4.80
Structural basis of PTH1R–β-arrestin core engagement reveals design principles for G-protein-biased therapeutics 1.00
Ligand binding modes of the bitter taste receptor T2R14 and T2R46 1.00
EMProt improves structure determination from cryo-EM maps 1.00
CryoAtom improves model building for cryo-EM 0.80
Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting 1.00
3 2.96
Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis 1.00
Cryo-EM structure enabling virtual screening for the discovery of highly potent TRPM3 antagonists with analgesic efficacy 0.96
Structural insights into the activation of TMEM175 by small molecule 1.00
4 3.80
Helical Aromatic Oligoamide Macrocycle Incorporated with a Ferrocene Unit for Encapsulation and Chirality Signaling of Zwitterionic Proline 0.80
Diversity-Oriented Enzymatic Modular Synthesis of N-Glycans Bearing LacdiNAc-Related Epitopes 1.00
Design and Evolution of an Artificial Aldolase with an Abiological Catalytic Cofactor in Apo-Myoglobin 1.00
RNA Acylation Method via a DNA-Templated Acyl Transfer Reaction 1.00
10 7.09
Type II tRNA cleavage by SLFN14 endoribonuclease variants linked to inherited thrombocytopenia drives global translational repression 0.08
Structured water molecules drive activation and G protein selectivity in the GPR174 receptor 1.00
Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors 1.00
Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells 0.88
Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans 0.10
Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue 0.04
Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity 1.00
The transcription factor SKN-1 drives lysosomal enlargement during aging to maintain function 1.00
Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway 1.00
Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract. 1.00
2 1.00
Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis 0.75
An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. 0.25
1 1.00
Unifying Constraints Linking Protein Folding and Native Dynamics Decoded from AlphaFold 1.00
1 1.00
Using Folded Proteins as Mechanically Well-Defined Units to Understand Fatigue Fracture in Hydrogels: Bridging Single Molecule and Bulk Studies 1.00
2 1.82
<atl>Staurosporine Targets Mitochondrial Regulator scpVdAtuA3/scp to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt</atl> 0.82
A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination-Mediated Degradation That Promotes Bacterial Infection 1.00
62 52.99
Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity 1.00
Navigating high-order protein fitness landscapes via deep learning on directed evolution trajectories 1.00
Apoptosis-inducing factor starts its activity within mitochondria revealed by in situ vibrational probes 1.00
Decoding the structure of GPR151 via NELiS 1.00
Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing 1.00
Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design 0.50
Unveiling the glymphatic system’s role in brain aging: A comprehensive biomarker and modifiable intervention target 1.00
Physiological super-resolution in situ recording reveals kinetic changes of sympathetic norepinephrine release in heart failure 0.96
Machine learning multiscale collective cell dynamics: From single-cell characterization to multicellular monolayer modeling 1.00
Plant pathogenic nematode exosomes remodel vector tracheae to enhance pathogen transmission 1.00
CHK2-USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis 1.00
Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates 1.00
Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases 0.03
CALHM5 deficiency alleviates aortic aneurysm by regulating smooth muscle calcium homeostasis 0.94
VAMP8 function reveals tight linkage between endocytic recycling and endocytosis 0.92
Identifying a cancer therapeutic target: Cell-SELEX identifies a membrane protein for aptamer-mediated growth suppression 1.00
Calsyntenin-3 suppresses inflammation via inhibition of TLR N-glycosylation and membrane localization 1.00
SEL1L–HRD1 ERAD–autophagy interplay maintains mitochondrial homeostasis in brown adipocytes 0.08
Unveiling hidden intermediate states in protein folding with AI-based conditional transition clustering 1.00
GalNAc-T13 maintains neurite architecture and memory retention via O-GalNAc glycosylation of seizure protein 6 0.75
Absolute hand determination of glycofibrils from natural sources in cryo-EM 1.00
mtDNA leakage promotes neuron–glia crosstalk to induce epilepsy by cGAS–STING-driven neuroinflammation and serine metabolic reprogramming 1.00
A Meier–Gorlin syndrome mutation impairs the loading of the MCM2–7 complex during DNA replication initiation 1.00
Allosteric coupling between PIP2 and Ca2+ binding sites gates TMEM16A channels 0.53
PLETHORA–autophagy axis activates organ regeneration through ROS modulation 0.14
A class of COPI cargo receptors regulates processing of transmembrane proteins by reinforcing their Golgi retention 1.00
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis 0.52
Spatially regulated mRNA translation enables functional membrane protein integration in synthetic cells 1.00
ER membrane receptors engage core autophagy machinery to initiate ER-phagy 1.00
Flexible protein–ligand docking with diffusion-based side-chain packing 1.00
Controllable gap junctions by vitamin B12 and light 1.00
Structural insights into nonpeptide antagonist inhibition of somatostatin receptor subtype 5 1.00
MLKL/retromer axis controls PD-L1 recycling to compromise antitumor immunity during VCP inhibition–induced necroptosis 1.00
A metabolic cell death program downstream of SARM1 couples NAD+ depletion to BAX activation and APAF1 degradation 1.00
<atl>Preassembly and independent trafficking of the exocyst complex in iArabidopsis/i</atl> 0.76
The intermediate filament protein GFAP regulates mitochondrial fission in astrocytes 0.11
Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration 1.00
mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation 0.90
Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance 0.88
ENKD1 attenuates antibacterial immunity by facilitating TRIM21-mediated RUBCN degradation to suppress LC3-associated phagocytosis 1.00
Extracellular nanobody screening using conformationally stable GPCR variants 1.00
Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization 1.00
A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking 0.05
Mitotic recombination events and single-base mutations induced by ultraviolet light in G1-arrested yeast cells 0.67
Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival 0.58
GeoEvoBuilder: A deep learning framework for efficient functional and thermostable protein design 1.00
Temperature adaptation in structure and function in lactate dehydrogenase-A reflects convergent evolution in a few key protein regions 0.80
Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics 1.00
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway 0.96
Binding of Fusobacterium nucleatum autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion 1.00
Hybridoma-inspired strategy crafts tailored multifunctional exosomes for precision therapy 1.00
Aspartic acid residues in BBE-like enzymes from Morus alba promote a function shift from oxidative cyclization to dehydrogenation 0.81
The fetal hydrops–associated single-residue mutation L322P disrupts mechanical but not chemical activation of the PIEZO1 ion channel 1.00
Time-resolved photocatalytic proximity labeling uncovers ER proteome dynamics underlying UPR-to-apoptosis transition 1.00
De novo design of a fusion protein tool for GPCR research 1.00
Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Ighm) as a tissue-level aging biomarker 1.00
Metabolic control of glycosylation forms for establishing glycan-dependent protein interaction networks 0.20
Cryo-EM structures of GnRHR: Foundations for next-generation therapeutics 1.00
Synthetic models of the nitrogenase FeMo cofactor 1.00
A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis 1.00
Establishment of cell size–dependent growth rate via differential scaling of metabolite uptake and release 0.88
Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen 1.00
6 4.83
Structural N- and O-glycans revealed by high-resolution cryo-EM analysis of tubular mastigonemes 1.00
Heritability of intrinsic human life span is about 50% when confounding factors are addressed 0.06
Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1 1.00
Glycolysis-compatible urethanases for polyurethane recycling 1.00
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling 0.93
Molecular evolution of sour tolerance in birds 0.85
42 30.68
53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination 1.00
mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy 1.00
High altitude–mediated immune remodeling accelerates aging 1.00
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis 0.13
Cryo-EM structures of human P2X2/3 heteromer channel reveal the structural basis of ligand selectivity 1.00
Harnessing cooperative sorbate-sorbent adaptation in a flexible metal-organic framework for switchable hydrocarbon separation 0.67
Cytoskeletal remodeling promotes tunneling nanotube formation and drives cardiac resident cell mitochondrial transfer in sepsis 0.96
Transmembrane proteins mediate basal complex assembly and individual daughter cell formation in malaria parasites 0.14
R-loop processing via REXO4-RNaseH1–mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity 1.00
Covalent capture and genetic code expansion enables chemoproteomic profiling and functional characterization of lysine acetoacetylation 1.00
Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation 0.06
Molecular and structural basis of a subfamily of PrfH rescuing both the damaged and intact ribosomes stalled in translation 0.43
DLX2 acts as a pioneer factor and drives Msx1+ ectomesenchyme formation from embryonic stem cells 1.00
Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers 1.00
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes 0.14
Galectin-3 exacerbates autoimmune diabetes by limiting regulatory T cell differentiation and function 1.00
Nanopore profiling and structure determination of oligosaccharides by fragmentation 1.00
Site-specific phosphorylation of LRP regulates FLC chromatin looping and flowering 0.14
Direct trapping of the transport-segment DNA by the central domain of type IIA topoisomerases 1.00
Athlete-derived extracellular vesicles protect against spinal cord injury via inhibition of neuronal ferroptosis 1.00
Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injury 1.00
AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer–regulated axis 0.80
miRNA-loaded biomimetic nanoparticles orchestrate gut microbe to ameliorate inflammatory bowel disease 1.00
Dynamic structures of a membrane transporter in native cellular membranes 0.90
NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C 0.34
The mechanical response of vinculin 0.11
Mechanical contribution of germ cell specification in Arabidopsis anthers 1.00
Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function 0.23
Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development 0.03
Generating theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization 1.00
Physics-informed deep learning for plasmonic sensing of nanoscale protein dynamics in solution 1.00
A sensory and motor neuropathy caused by a genetic variant of NAMPT 0.20
Ultrafast and scalable synthesis of enzyme-metal hybrid catalysts in evaporating microdroplets 1.00
AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration 0.91
RPA1 protects DNA damage–induced PANoptosis in limb development 1.00
Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine 1.00
Heterochronic parabiosis uncovers AdipoR1 as a critical player in retinal rejuvenation 1.00
Ion channel structure and function of the MERS coronavirus E protein 0.44
Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis 0.95
Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease 0.84
Gating of hair cell Ca2+ channels governs the activity of cochlear neurons 0.25
Chemical synthesis uncovers the significant impact of natural glycosylation on islet amyloid polypeptide aggregation 1.00
1 1.00
Acarbose ameliorates podocyte injury and glomerular lesions in diabetic nephropathy through USP46 activation 1.00
11 9.45
The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A ESCRT-mediated lysosomal repair 1.00
FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer’s disease pathology 0.89
Novel tissue mechanics-guided cellular flows drive the formation of feather follicles 0.08
Structural insight into ligand binding and activation of the orphan GPCR Mas1 1.00
A non-canonical ARMS-GABARAP interaction modulates dendritic spine formation and synaptic development 1.00
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion 0.94
E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival 1.00
PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis. 0.88
Reticulophagy receptor FAM134C restrains BMP receptor signaling 1.00
Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat. 0.75
Rbm24a dictates mRNA recruitment for germ granule assembly in zebrafish 0.91
3 2.81
Iron plaques as terminal electron acceptors optimize clostridial fermentation and nitrogen fixation in rice rhizospheres 1.00
Synergistic interaction between microbial nitrogen fixation and iron reduction in the environment 0.91
Inositol phosphates as an overlooked phosphorous source in marine ecosystems 0.90
5 5.00
Deep Learning of Protein Structure and Physicochemical Properties from Two-Dimensional Infrared Spectra 1.00
Redesign to Mechanism: Interpretable AI Reveals Determinants of Protein Hydrate Binding 1.00
Efficient and Accelerated Protein Free Energy Landscape Reconstruction via Conditional Variational Autoencoders 1.00
Aromatic Residues Tune Excited-State Proton-Coupled Electron Transfer in BLUF Domains: Insights from CASPT2/MM Calculations 1.00
Revealing Dynamics-Mediated Effects of Pathogenic Missense Mutations on Menin Protein Function 1.00
3 2.64
FaNUDT19 contributes to 5′ cap quality control by modulating NAD+ capped RNA dynamics during strawberry fruit ripening 0.75
Substrate specificity and transport mechanism of the chloroplast dicarboxylate transporters DiT1 and DiT2 1.00
NUP50c defines a conserved nuclear basket module with NUP82 and NUP136 to mediate mRNA export and gene regulation in plants 0.89
1 1.00
Dimethyl sulfoxide as a qualitative EPR indicator of sulfate radical in advanced oxidation processes 1.00

Numerical information only (in the tables above) is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International.