Biochemistry and Cell Biology articles for Germany

Time frame: 1 June 2025 - 30 May 2026

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Count: 377

Article ‘Count’ for Biochemistry and Cell Biology.

Journal Count Share
2 1.27
Engineered Coiled-Coils Convert Cholera Toxin B-Pentamers into Programmable Membrane Fusogens 0.27
Morphology-Aware Peptide Discovery via Masked Conditional Generative Modeling 1.00
2 1.17
In vitro characterization of endothelial damage from rapid multiaxial mechanical loading 0.17
Protein Corona Fingerprinting of Exocytosed Nanoparticles Reveals Time-Dependence of Exocytosis Pathways 1.00
2 1.13
Shear‐Induced CROSS (Cellular RedOx Spreading Shield) Assembly Sustains Neurotrophic Extracellular Vesicle Production for Functional Neural Networks 0.13
Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems 1.00
1 0.94
Multiphysics‐Driven Assembly of Biomimetic Vesicles 0.94
2 0.69
Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly 0.26
Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies 0.43
13 7.47
Analyses of Individual Singly Charged Ions Using a High-Field Orbitrap Analyzer 0.25
Cryogenic Gas-phase IR Spectroscopy on a Commercial Ion Mobility-Mass Spectrometry Platform 0.78
A Reversible ATR-FTIR Biosensor with Single-Residue Sensitivity 1.00
Impact of High Mannose Glyco Pairing on the Pharmacokinetics of a Therapeutic monoclonal antibody using an Immunocapture-LC/MS Intact Assay 0.43
Deconvolution of High-Dimensional Ion Mobility Data Using Reversible-Jump Markov Chain Monte Carlo 1.00
Unlocking Rare 3-O-Sulfation Patterns in Heparan Sulfate via ARSG-Directed Regioselective Desulfation and HILIC-MS 0.38
Application of the Ninhydrin Reaction for Quantification of Total Protein Contents: Establishment of Conversion Formulas 1.00
The Simplest Method Yet for Ultrafast Desalting of Proteins and Oligonucleotides in Native Mass Spectrometry 0.90
Establishing 18O-Labeled Inositol Phosphates for Quantitative Capillary Electrophoresis-Mass Spectrometry: Fragmentation Pathways and Comparison with 13C-Labeled Analogs 1.00
A Systematic Analysis of Microstructured Silicon ATR-FTIR Reflection Elements: Operating Parameters, Performance, and Underlying Phenomena 0.14
Histone Analysis Using Mobility- and Mass-Selected Ultraviolet Photodissociation in Tandem with Ultra-High-Resolution Mass Spectrometry 0.08
Enhancing Sensitivity in Low-Load Proteomics Orbitrap Workflows via SLIM Integration 0.23
Electron Capture-Induced Charge Reduction Benefits the Recording of Ultralong Transients in Orbitrap-Based Individual-Ion Mass Spectrometry 0.29
22 14.80
Nano-Gs Protein Peptidomimetics: Rational Design of Gα C-Terminus-Derived Peptides Mimicking Key Components of Gs-β2AR Interactions 0.33
Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance 0.11
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase 0.01
The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies 0.07
Multicyclic D-Stereospecific Hydrolase Dimer With High Sustained Activity 0.45
Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α 1.00
Fluorinated Glycan Frameshifts: Automated Synthesis Expedites the Study of Glycan-Protein Interactions by 19F-BioNMR 0.64
Chemical Synthesis of Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii Capsular Polysaccharide Fragments as Leads for Cross-Protection 0.60
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily 1.00
Genetic Encoding of Pentafluorophosphato-Phenylalanine Provides PF5-Proteins as Phosphoprotein Mimetics 0.73
The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA 0.33
From Pharmacophore to Warhead: NAD+-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors 0.97
Conformational Quenching in an Engineered Lipocalin Protein Achieves High Affinity Binding to the Toxin Colchicine 0.71
Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High‐Efficiency Synthesis 1.00
Selective Chemical Manipulation of Mannosyl- and Galactosyl-Queuosine in tRNAs of Living Cells 1.00
Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP-InsP4 Isomers in Plant Signaling 1.00
A Genetically Encoded Homocysteine Precursor to Probe Protein Active Sites and to Addict Escherichia coli to a Noncanonical Amino Acid Directly Involved in Catalysis 1.00
Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering 0.83
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound-Responsive RNA Toolkit 1.00
Supramolecular Ion Channels to Engineer Znsup2+/sup Ion Transport Mediated Chemical‐to‐Optical Signal Transduction 0.20
Chemically Fueled Active Transport 1.00
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2-Adrenoceptor 0.80
1 0.07
Post-transcriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML 0.07
1 1.00
Endosomal 2Cl−/H+ exchangers regulate neuronal excitability by tuning Kv7/KCNQ channel density 1.00
1 0.12
Lymphoma accelerates T cell and tissue aging 0.12
1 0.05
Extracellular Vesicle-Packaged miR-99a Reprograms Fibroblasts to Create an Inflammatory Niche that Drives Colorectal Cancer Metastasis. 0.05
5 2.48
Light-directed evolution of dynamic, multi-state, and computational protein functionalities 0.29
Continuum architecture dynamics of vesicle tethering in exocytosis 0.14
Membrane potential mediates the cellular response to mechanical pressure 0.06
Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 1.00
The small GTPase Ran defines nuclear pore complex asymmetry 1.00
2 1.13
Bempedoic acid directly binds and activates PPARα 1.00
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function 0.13
1 1.00
Synthesis and characterization of l-3-(pentafluorophosphato-difluoromethyl)-alanine, a structural and functional mimetic of phosphoserine 1.00
4 3.75
Mapping the nonribosomal specificity code through promiscuity-guided A-domain engineering 1.00
Design rules for adhesion-driven synthetic cell motility on dynamic membranes 1.00
Synthesis of monodisperse inorganic polyphosphate polyPsub10/subivia/i a photocaging strategy 1.00
A screening approach unveils an unknown Mn2+-dependent endopolyphosphatase activity in yeast 0.75
4 2.29
Myosin II-driven contractions of supporting cap cells promote sensory adaptation of Drosophila proprioceptors 0.61
Thermal-state-dependent control of body temperature and feeding by two intra-hypothalamic pathways 1.00
Store-independent activation of STIM1-ORAI1 by SPCA2 determines the basal CFTR activity in secretory epithelial cells 0.05
Corrections in single-cell migration path in vivo are controlled by pulses in polar Rac1 activation 0.63
4 0.65
A lineage-specific selective autophagy receptor module mediates P-body turnover 0.22
Tissue-scale mapping reveals a central role of hepatoblasts in the regulation of fetal liver hematopoiesis and stem cell maintenance 0.11
Mitogen-activated kinase 6 facilitates autophagy initiation to confer salt tolerance in maize 0.17
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants 0.15
2 0.98
Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction 0.04
Endothelial ZBTB16: a molecular shield against cardiac aging 0.94
1 0.63
The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function 0.63
1 0.98
GSK3βhigh/NFATc1high subtype targeting overcomes therapy resistance in pancreatic cancer through transcriptional induction of homologous recombination repair 0.98
1 0.88
Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier 0.88
3 1.45
Iron to Cobalt Swapping in a Bioinspired Heme-Peroxidase: Structural Characterization and Functional Implications 0.25
Recasting Nitrogenase’s Carbide Role as a Beating Heart of Steel: A Joint Inorganic and Organic Perspective for μ6Carbide–Iron Bonding 1.00
EPR and 31P ENDOR Characterization of Pseudo-Jahn–Teller Dynamics and N2 Activation in Functional Nitrogenase Models, P3EM(N2) (M = Fe, Co; E = Si, B, C) 0.20
17 7.94
The inositol pyrophosphate 5-InsP7 regulates mitochondrial polyphosphate synthesis and bioenergetic function 0.14
Structure–function analysis of the bacterial ClpE–ClpP AAA+ protease 0.83
Functions of prolyl hydroxylation in elastin 0.33
Identification of a distinct family of polyphosphate kinases relevant to energy homeostasis in Crenarchaeota 0.64
The Antiseizure Medication Stiripentol Inhibits Mitochondrial Complex I by Blocking Early-Stage Electron Transfer 0.21
GRK phosphorylation drives β-arrestin–independent internalization of chemokine receptor CXCR5 0.43
Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions 0.60
Phosphorylation at S1288 of Leukemia Associated RhoGEF (LARG/ARHGEF12) induces plasma membrane localization and promotes binding and activation of RhoA 0.25
Tetramerization of the DNA mismatch repair protein MutS enhances daughter strand incision preferentially in the vicinity of replication errors 0.13
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1 0.03
SAG1.3-derived Frizzled-targeting small-molecule compounds 0.40
WNT7A/B assemble a GPR124-RECK-LRP5/6 coreceptor complex to activate β-catenin signaling in brain endothelial cells 0.83
Small molecule agonist TPC2-A1-N increases intracellular Ca2+ independent of two-pore channels 1.00
A dynamic structural framework for the allosteric regulation of Hsp70 chaperones 1.00
Armless hairpin-like tRNAs in Romanomermis culicivorax: Evolutionary adaptation of a mitochondrial elongation factor EF-Tu 1.00
Understanding the substrate recognition and catalytic mechanism of 2-O-methyl fucosidases from glycoside hydrolase family 139 0.07
Molecular basis for Gβγ-SNARE mediated inhibition of synaptic vesicle fusion. 0.04
9 4.52
A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells 0.22
Spectrin coordinates cell shape and signaling essential for epidermal differentiation 0.63
Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1 0.04
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in toxoplasma 0.80
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors 0.17
Vesicle adaptors in malaria parasites show conservation and flexibility of protein sorting machinery 0.83
Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation 0.12
Myosin 15 participates in assembly and remodeling of the presynapse 1.00
Anillin mediates unilateral furrowing during cytokinesis by limiting RhoA binding to its effectors 0.71
1 0.08
Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms 0.08
2 1.35
Dynamic balance of myoplasmic energetics, redox state and protons in a fast‐twitch oxidative glycolytic skeletal muscle fibre 0.60
A simple voltage‐modulated Markov chain model for the Piezo1 ion channel to investigate electromechanical pacing 0.75
18 11.75
GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening 0.87
Leveraging Glycan–Glycan Interactions to Tune the Conformation of Glycan Hairpins and Build Rigid 3D Architectures 0.57
Mechanisms of Hydroxyl Radical Chemistry in Aqueous Solution Triggered by Photoexcitation and Probed by Soft X-rays 1.00
De Novo Design of Glycan Foldamers with Programmable Tertiary Structure 0.60
Framework for Quantifying the Efficiency of Competing Signal Transmission Modes in Proteins 0.80
Optimizing Stability in Dynamic Small-Molecule Binding Proteins 0.63
The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling 0.30
Fine-Tuning of the Neuropeptide Y1 G Protein-Coupled Receptor by the Tryptophan6.48 “Toggle Switch” 1.00
Unravelling Catalytic Divergence in Mo- and Fe-Only Nitrogenases: The Role of the Heterometal-Site and Protein Environment from QM/MM Insights 0.67
Covalent Drug Binding in Live Cells Monitored by Mid-Infrared Quantum Cascade Laser Spectroscopy: Photoactive Yellow Protein as a Model System 0.13
Methyl-Containing Iron–Sulfur Cluster with FeMoco Geometry 0.50
NRVS Spectroscopy Resolves Distinct Bridging Hydride Intermediates in [NiFe]-Hydrogenase 1.00
Stapling of β-Glucans Increases Antibody Binding 1.00
A Dinitrogen Complex without Donor Ligands: Isolation and Characterization of a [Mn(CO)5(η1-N2)]+ Salt 0.57
Oxidatively Induced Reductive N2 Binding: A Dinickel-Bridging Bent N2 Radical Anion and Its Redox-Triggered N2 Release 1.00
Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy 1.00
Photochemistry of Sulfur Dioxide Mediated by Charge Transfer through Intermolecular Chalcogen Bonds 0.10
Spatial Configuration-Guided Design of Covalent Organic Framework-Based Artificial Metalloantioxidases for Inhibiting Inflammatory Cascades and Regulating Bone Homeostasis 0.03
1 0.91
Mechanisms of Podocyte Injury Due to Loss of the Nucleoporin NUP93. 0.91
9 4.68
Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt 0.97
Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators 1.00
BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes 0.03
Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins 0.82
KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1 0.07
An NADH-controlled gatekeeper of ATP synthase 0.72
Interaction with AK2A links AIFM1 to cellular energy metabolism 0.90
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging 0.07
YTHDF1 differentiates the contributing roles of mTORC1 in aging 0.11
1 0.80
Single-cell characterization of the adult male hippocampus suggests a prominent, and cell-type specific, role for and in response to a social stressor 0.80
15 6.58
Universal transcriptomic hallmarks of mammalian ageing and mortality 0.02
SNOR promotes translation restart after dormancy 0.20
Glycerol-driven TNAP activation in thermogenesis and mineralization 0.08
Thymic health consequences in adults 0.01
Robust cytoplasmic partitioning by solving a cytoskeletal instability 0.75
LetA defines a structurally distinct transporter family 0.06
Ligand-specific activation trajectories dictate GPCR signalling in cells 1.00
A mechanical ratchet drives unilateral cytokinesis 1.00
ZAK activation at the collided ribosome 0.45
Hijacking a bacterial ABC transporter for genetic code expansion 0.36
Design of facilitated dissociation enables timing of cytokine signalling 0.11
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases 1.00
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis 0.10
The role of metabolism in shaping enzyme structures over 400 million years 0.43
Developmental trajectory and evolutionary origin of thymic mimetic cells 1.00
2 0.11
Antibody-lectin chimeras for glyco-immune checkpoint blockade 0.10
Democratizing protein language model training, sharing and collaboration 0.01
5 2.80
Tissue rigidity phase transition shapes morphogen gradients 0.57
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis 0.12
Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 1.00
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration 1.00
Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery 0.11
6 2.44
Trafficking of a nitrogenase FeMo-cofactor assembly intermediate 0.50
Hetero-oligomerization drives structural plasticity of eukaryotic peroxiredoxins 0.67
Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 0.01
Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly 0.13
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis 0.13
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation 1.00
2 1.61
Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation 1.00
Navigating protein landscapes with a machine-learned transferable coarse-grained model 0.61
104 49.30
Structure-based screening and a conformational biosensor identify a GPR183 inverse agonist and an activation switch 0.14
Deciphering cytokine-driven ADP-ribosylation signaling networks via Af1521-based mass spectrometry analysis of labile Glu/Asp-linkages 0.10
Open-channel block of human TRPV6 by polyamine spermine 0.44
Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation 0.05
DepoCatalog: mapping diversity of 129 recombinantly produced Klebsiella phage depolymerases 0.13
Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM 0.58
A dual phospholipase system instructs membrane hydrolysis during the final stages of plant autophagy 0.03
TBK1 restricts IRGQ-mediated autophagy 1.00
Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes 0.15
Synthesis of sialylated human milk oligosaccharides by automated glycan assembly 1.00
Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities 0.02
AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria 1.00
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors 0.02
The vault associates with membranes in situ 0.92
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging 0.73
Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira 0.08
Phage-assisted evolution of allosteric protein switches 1.00
Translation in proximity to forming autophagosomes during sustained autophagy 0.25
Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors 1.00
Bacterial extracellular vesicles as recyclable nutrient reservoirs 0.44
Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model 0.11
Interplay of SLC33A1-dependent and -independent Golgi sialic acid -acetylation in CASD1 catalysis 0.68
Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing 0.78
Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter 1.00
Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins 0.86
NorQD AAA+ complex drives metal insertion by a twisting mechanism 0.33
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion 0.11
Structural transitions in the stepwise assembly of proteasome core particles 1.00
Parkinson’s disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer 0.07
Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B 0.85
MFF budding from mitochondria regulates melanosome size and maturation 0.10
Lifestyle change accelerates epigenetic ageing in King penguins 0.11
CPF-CF-terminated snoRNAs shuttle through the cytoplasm via an mRNA guard protein-mediated surveillance mechanism 1.00
Adaptations in tubulin determine distinct microtubule architectures, mechanics and drug susceptibility 0.25
A protein adaptor mediating Ap4A-dependent control of protein acetylation 0.67
Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells 1.00
Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice 0.40
TANGO: Analysis and curation of particles in cryo-electron tomography 1.00
Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis 1.00
A multivalent adaptor mechanism drives the nuclear import of proteasomes 0.19
Quantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles 0.07
Subcellular glycan-mannose receptor binding kinetics correlate with myeloid cell function 0.11
4EHP and NELF-E regulate physiological ATF4 induction and proteostasis in disease models of Drosophila 0.17
Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism 0.22
Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response 0.11
3D-MINFLUX nanoscopy reveals distinct allosteric mechanisms for activation and modulation of PIEZO1 by Yoda1 1.00
Enantioselective protein affinity selection mass spectrometry (E-ASMS) 0.14
TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis 0.50
In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7 0.13
Structural characterisation of the fungal Pmt4 homodimer 0.79
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons 1.00
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses 0.13
GlyContact analyzes glycan 3D structures at scale 0.08
Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration 0.06
Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis 0.13
Investigating the neuronal role of the proteasomal ATPase subunit gene in neurodevelopmental proteasomopathies 0.14
Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth 0.22
Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels 0.11
The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A 0.13
Positional programs in early murine facial development and their role in human facial shape variability 1.00
Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging 0.94
The locking mechanism of human TRPV6 inhibition by intracellular magnesium 0.38
SND3 is the membrane insertase within a distinct SEC61 translocon complex 1.00
Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides 1.00
Structural basis of apoptosis induction by the mitochondrial voltage-dependent anion channel 1.00
Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate 0.15
Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks 0.18
Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study 0.22
Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors 0.75
HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane 0.06
Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing 1.00
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor 0.45
Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide Y receptor regulate arrestin-3 recruitment 0.98
Structural basis for DNA break sensing by human MRE11-RAD50-NBS1 and its regulation by telomeric factor TRF2 1.00
Mechanism and function of GPR3 regulated by a negative allosteric modulator 0.60
Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores 0.80
Structural basis for the recognition and ubiquitylation of type-2 -degron substrate by PRT1 plant -recognin 0.22
Promiscuous and multivalent interactions between Eps15 and partner protein Dab2 generate a complex interaction network 0.75
The Escherichia coli replication initiator DnaA is titrated on the chromosome 0.10
Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol 0.07
IWS1 positions downstream DNA to globally stimulate Pol II elongation 1.00
Ca-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range 0.94
MacroD1 sustains mitochondrial integrity and oxidative metabolism 0.18
Capturing nematic order on tissue surfaces of arbitrary geometry 0.07
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes 0.82
Conservation of dark CPD photolyase function in blind cavefish 0.64
Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons 0.63
Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo 0.17
The EMC acts as a chaperone for membrane proteins 1.00
Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier 0.03
Te and Fe nuclear resonance vibrational spectroscopic characterization of intermediate spin state mixed-valent dimers 0.56
Restriction of Ku translocation protects telomere ends 0.06
LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling 0.06
Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation 0.68
Muscle AMP deaminase activity was lower in Neandertals than in modern humans 0.29
Concurrent diffusion of nicotinic acetylcholine receptors and fluorescent cholesterol disclosed by two-colour sub-millisecond MINFLUX-based single-molecule tracking 0.50
Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation 1.00
A multi-tiered mechanical mechanism shapes the early neural plate 0.13
Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation 0.94
Data-driven protease engineering by DNA-recording and epistasis-aware machine learning 0.17
Enhancing autophagy by redox regulation extends lifespan in Drosophila 0.11
TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family 0.33
Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R 0.05
Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux 0.56
1 0.83
Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells 0.83
1 0.10
Mechanisms of active wetting and fluidification in epithelial cell collectives 0.10
1 0.02
The exposome of brain aging across 34 countries 0.02
4 2.20
Clustering the protein universe of life using DIAMOND DeepClust 0.92
ExoSloNano: multimodal nanogold labels for identification of macromolecules in live cells and cryo-electron tomograms 0.08
GPU-accelerated homology search with MMseqs2 0.20
Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites 1.00
2 1.93
Glycan atlassing enables functional tracing of cell state 0.93
Ångström-resolution imaging of cell-surface glycans 1.00
1 0.46
Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment 0.46
11 6.01
Rap1-mediated steric hindrance protects telomeres from MRX sensing 0.06
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway 0.12
MTCH2 promotes BAX and BAK self-assembly and apoptotic pore growth 0.80
Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15 1.00
CryoAtom improves model building for cryo-EM 0.20
High-throughput peptide-centric local stability assay extends protein–ligand identification to membrane proteins, tissues and bacteria 1.00
Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition 1.00
Establishment of the phagophore–ERES membrane contact site initiates phagophore elongation 0.30
Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2 0.67
Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles 0.60
P-type ATPase magnesium transporter MgtA acts as a dimer 0.27
5 2.67
Mitochondrial fission factor regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons 1.00
TMEM145 is a principal component of outer hair cell stereocilia 0.50
Cryo-EM structure enabling virtual screening for the discovery of highly potent TRPM3 antagonists with analgesic efficacy 0.04
Ultrastructural membrane dynamics of mouse and human cortical synapses 0.18
Feeding-induced olfactory cortex suppression reduces satiation 0.94
1 0.10
Helical Aromatic Oligoamide Macrocycle Incorporated with a Ferrocene Unit for Encapsulation and Chirality Signaling of Zwitterionic Proline 0.10
1 0.83
A protein-specific priority code in presequences determines the efficiency of mitochondrial protein import 0.83
4 3.56
Local mitochondrial physiology defined by mtDNA quality guides purifying selection 1.00
Defining the high-translational readthrough stop codon context. 1.00
Distinct domains of ENHANCER OF PINOID hold information for its polarization required for auxin-mediated cotyledon and flower development in Arabidopsis. 1.00
A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish 0.56
1 1.00
Repulsive Particle Interactions Enable Selective Information Processing at Cellular Interfaces 1.00
1 1.00
Allosteric Lever: Toward a Principle of Specific Allosteric Response 1.00
23 10.72
Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design 0.21
Dynamic switching of cell–substrate contact sites allows gliding diatoms to modulate the curvature of their paths 1.00
ATP synthase activity boosts membrane proton acceptance and lateral diffusion 0.50
PLETHORA–autophagy axis activates organ regeneration through ROS modulation 0.14
Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery 0.22
Proton-selective conductance and gating of the lysosomal cation channel TMEM175 0.94
Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts 0.31
The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5 0.71
The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion 0.29
A model for boundary-driven tissue morphogenesis 0.33
Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma 0.03
Subtype-specific structural features of the hearing loss–associated human P2X2 receptor 0.28
Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors 0.11
STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling 0.33
Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan 0.09
Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates 1.00
In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment 0.13
Neuronal processes contain the essential components for the late steps of ribosome biogenesis 1.00
Structures of Chaetomium thermophilum TOM complexes with bound preproteins 1.00
Ena/VASP-EVH1 inhibition prevents chemotaxis and metastasis by blocking the EVH1–WAVE2 interaction 0.79
Basic interactions responsible for thymus function explain the convoluted medulla shape 1.00
Amortized template matching of molecular conformations from cryoelectron microscopy images using simulation-based inference 0.29
A mouse model of Jansen’s metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics 0.03
1 0.05
Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon. 0.05
6 3.74
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality 0.88
Altered translation elongation contributes to key hallmarks of aging in the killifish brain 0.65
Silencing mitochondrial gene expression in living cells 1.00
Scalable emulation of protein equilibrium ensembles with generative deep learning 0.06
The intracellular Ca2+ sensitivity of transmitter release in glutamatergic neocortical boutons 1.00
Molecular evolution of sour tolerance in birds 0.15
29 15.35
Architecture of clathrin-independent AP3:ARF1-coated carriers 0.32
Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET) 0.79
Reconstituted nascent adhesion condensates drive actin polymerization on supported lipid bilayers 1.00
Three cryo-EM structures of complement C3d-bound αMβ2 reveal an unexpected layer of dynamics for αI-containing integrin receptors 0.08
Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast 1.00
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis 0.08
Selective, genetically induced increase in synaptic vesicle priming 0.33
Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo 0.50
Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer 0.36
Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation 0.67
Injury-induced electrochemical coupling triggers organ growth 0.90
A transposase-derived gene required for human brain development 0.05
Real-time imaging of rotation during synthesis by the replisome 0.60
TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1 0.13
AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer–regulated axis 0.05
NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C 0.03
In situ structure of a gap junction–stomatin complex 0.83
Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy 1.00
Cluster nanoarchitecture and structural diversity of PIEZO1 at rest and during activation in intact cells 1.00
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing 0.89
Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development 0.27
Mechanochemical waves in focal adhesions during cell migration 0.29
The mechanistic basis of cargo selection during Golgi maturation 0.38
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned 0.93
Cryo–light microscopy with angstrom precision deciphers structural conformations of PIEZO1 in its native state 1.00
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration 0.33
Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5 0.29
Gating of hair cell Ca2+ channels governs the activity of cochlear neurons 0.56
Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain 0.68
15 9.00
Atg18 interaction positions Atg2 for efficient lipid transfer into phagophore elongation 0.71
SenSet defines cell-type specific senescence signatures in the aged human lung 0.08
Stress-induced OMA1-mediated cleavage of AIFM1 suppresses cell growth by controlling mitochondrial OXPHOS activity 0.43
Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease 0.17
Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis 1.00
MYO5A-mediated stabilization promotes the acquisition of fusion competence in sealed autophagosomes 0.33
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues 0.09
The origin of septin ring size control in budding yeast. 0.67
Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage. 1.00
The INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair 1.00
Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization. 0.50
Proteomic aging signatures across mouse organs and life stages. 1.00
ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains. 0.92
Mechanistic insights into Bcs1-mediated mitochondrial membrane translocation of the folded Rieske protein 1.00
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish 0.11
1 0.09
Synergistic interaction between microbial nitrogen fixation and iron reduction in the environment 0.09

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