Biochemistry and Cell Biology articles for Chinese Academy of Sciences (CAS), China

Time frame: 1 June 2025 - 30 May 2026

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Count: 197

Article ‘Count’ for Biochemistry and Cell Biology.

Journal Count Share
6 2.12
Deterministic Evolution of Aptamers via a Microfluidic-Integrated Robotic Platform Using Complex Exosomes as Targets 0.56
Separation-Free Extracellular Vesicle Microribonucleic Acid Profiling Using Structurally Oriented Membrane Fusion and Spatially Confined Amplification 0.46
Sr-, Ca-Doped BaTiO3 with Synergistic Piezoelectric Catalysis and Microbial Balance Effects Enables Tooth Whitening for Home Oral Health 0.35
Interferon-γ-Induced Mesenchymal Stem Cell Exosomes Attenuate Chondrocyte Senescence and Osteoarthritis Progression by Hsp70 0.06
Hydrogel Loaded with Aminoethyl Anisamide-Modified Exosomes Attenuates Hepatic Fibrosis by Targeting Activated Hepatic Stellate Cells 0.07
A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senescence-Associated Phenotypes 0.63
11 4.19
A Potassium Phosphoramidate-Based Strategy for Compiling and Profiling the Noncanonical N‑Phosphoproteome of Nasopharyngeal Carcinoma 0.19
Label-Free, AI-Driven Evanescent Microscopy Decodes Single-Cell Membrane Protein Binding Kinetics and Adhesion Biomechanics 0.22
Streamlined Digital Microfluidics-Mass Spectrometry Strategy for Extracellular Vesicle Enrichment and Lipid Profiling 0.03
A Dual-Cascade Activatable Photoacoustic Sensor for Tracking Iron(II) and Reactive Oxygen Species during Ferroptosis 0.09
DSPE-Ti-Chip: A Dual-Functionalized Microfluidic Device for High-Efficiency Isolation of Extracellular Vesicle from Microvolume Biofluids 0.72
Ultrasensitive Profiling of Extracellular Vesicles by a Microbead- and Aptamer-Enhanced Thermophoretic Assay for Monitoring Therapeutic Responses 0.39
Lipidomic Profiling of Metastatic Lung Cancer-Derived Exosomes Unveiling Ceramides as Potential Biomarkers by Supramolecular Probe Enrichment and Mass Spectrometry Analysis 0.54
Robust Identification of Gas Mixtures from FTIR Spectra using Attention Mechanism to Mitigate Instrument Line Shape Variations 0.90
Tuning Microenvironment over Metal–Organic Frameworks for Efficient Enzyme Immobilization and Sensitive Immunoassay 0.08
A Label-Free Method Combining Chromatography Enrichment with N-Terminal Specific Proteolysis Enables Sensitive Identification of Tn/sTn Glycosites 0.33
Accurate Diagnosis of Colorectal Cancer Using a Combination of Lectin-Induced Recombinase Polymerase Amplification and CRISPR/Cas12a Assay on a Point-of-Care Testing Platform with Deep Learning Assistant 0.68
13 4.58
A De Novo Chemoenzymatic Assembly Strategy Enables the Efficient Preparation of a Large Core-Xylosylated N-Glycan Library for Probing Antibodies Against Schistosoma japonicum 0.50
Supramolecular Assembly of Proteoliposomes Containing Photosensitizers Regulating Energy Synthesis 0.04
Bioinspired Molecular Engineering of IRE1‐Gated DNAzymes for Self‐Adaptive Bidirectional Modulation of ER Stress 0.40
High‐Performance Artificial Lithium Channel Enabled by a Brominated Organic Imine Cage 0.13
Chemoenzymatic Synthesis of Glycopeptide Library Decodes Sialylation-Dependent Immunodominance to Enable a Potent Multicomponent Antitumor Vaccine 0.26
Chemoenzymatic Synthesis and Antigenicity Evaluation of an O-Antigen Octadecasaccharide from Helicobacter pylori 0.44
Flexible Crown-Ether Polyimides Break the K+/Na+ Selectivity Barrier in Artificial K+ Channels 0.13
Flipping of a Non-productive Substrate Binding Conformation Facilitates Hydroxynitrile Lyase Catalyzed Hydrocyanation 0.08
A Reversible Chemoenzymatic Labeling Strategy for Profiling of Protein O‐Glucosylation 0.75
Programmable Chemoenzymatic Assembly of a Bisected and Core-Fucosylated N-Glycan Library Reveals Glycan-Binding Protein Specificity and Branch Preference 0.57
TASK2-Inspired pH-Gating Polymeric Nanochannels with Multiple Interconvertible Permeability States by Synergistic Regulation of Conformation and Charge 0.28
Fulcrum Occupancy–Leverage Perturbation Strategy Enables Rapid Discovery of Potent CDK2–Cyclin A2 Interaction Inhibitors 0.42
Identification of Isomerically Diverse Ginsenosides Using Engineered Aerolysin Nanopore via Non‐Translocation Blockade Sensing 0.58
1 0.11
Translation of GGC repeats into a toxic polyglycine protein in oculopharyngodistal myopathy type 2 0.11
4 0.51
Engineered commensals for metabolic modulation of the gut-liver-brain axis 0.02
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator 0.08
Protein restriction reprograms the multi-organ proteomic landscape of mouse aging 0.05
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures 0.36
1 0.45
Exploring functional insights into the human gut microbiome via the structural proteome 0.45
1 0.68
RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation 0.68
1 0.02
Smooth muscle cells transiently acquire a CD34+ progenitor state upon injury to drive pathological vascular remodeling 0.02
1 0.38
A novel method for Tn antigen detection based on chemoenzymatic targeted labelling and CuAAC click chemistry 0.38
4 1.20
Deep profiling reveals coordinated remodeling of ganglioside metabolism in MCF-7 breast cancer cell line 0.08
Protein-encapsulated fluorogenic probes for the selective detection of endogenous O-GlcNAcase (OGA) 0.33
Unifying sequence-structure coding for advanced protein engineering via a multimodal diffusion transformer 0.19
GlycanInsight: an open platform for carbohydrate-binding pocket prediction and characterization 0.59
1 0.03
FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1 0.03
1 0.15
TRPM-mediated mechanoreception regulates myosin oscillation during tissue elongation 0.15
2 0.60
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging 0.45
TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi-selective autophagy 0.15
1 0.40
Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations 0.40
1 0.41
Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence 0.41
1 0.20
Reduction of Hexaazatrinaphthylenes by Masked Divalent Lanthanide Dinitrogen Reagents 0.20
1 0.50
PERK and IRE1α promote exosome secretion via blocking lysosomal degradation of multiple vesicular body 0.50
4 1.12
Plasma membrane-to-lysosome FGR signaling regulates endocytosis-associated lysosome homeostasis 0.15
TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion 0.07
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb 0.39
The autophagy protein ATG-9 regulates lysosome function and integrity 0.50
13 5.05
Nanopore-Based Glycan Sequencing via a Fragmentation-Reassembly Strategy 0.44
Single-Feature Identification of α2–8 Linked Sialoglycans Using Engineered Aerolysin Nanopores: A Paradigm for Glycan Linkage Analysis 0.50
Measuring Sodium Transport in Cells with Nuclear Magnetic Resonance 0.07
Cancer Metastasis Blockage by Exosome-Neutrophil Nanocoupler 0.44
A Tumor-Selective Self-Assembling Network of Poly(amino acid) Induces Cascading Bystander Cytotoxicity through Microvesicle Fission Amplification 0.70
Mismatched Nucleotide Rejections at the Open and Ajar States of DNA Polymerase I Ensure High Fidelity 0.71
Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines 0.10
De Novo Chemoenzymatic Assembly of Complex Sulfated N-Glycans to Comprehensively Profile the Ligand Binding of Human Siglecs 0.83
Cyclization Decoded: Engineering Amylomaltase for Efficient α-Glucan Transformations 0.60
Tailoring Artificial Hydration Microenvironments in Covalent Organic Frameworks for Enhanced Enzymatic Catalysis in Organic Media 0.05
Preorganized Internal Electric Field Enables Nucleophilic Attack of a Nonactivated Water Molecule in Thymine DNA Glycosylase 0.07
Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications 0.26
A Designed Zn2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases 0.29
6 1.33
Mechanosensory channels mediate ER Ca2+ transients to trigger assembly of autophagosome initiation sites for degradation of ER subdomains 0.77
The Erlin1/2 complex is a dynamic scaffold for membrane microdomain assembly on the endoplasmic reticulum 0.12
Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression 0.10
Structural characterization of five functional states of metabotropic glutamate receptor 8 0.03
KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1 0.29
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma 0.02
6 1.09
β-Arrestin condensates regulate G-protein-coupled receptor function 0.05
Steric hindrance of antibody binding in an Omicron spike fusion intermediate 0.18
Structures of Ostα/β reveal a unique fold and bile acid transport mechanism 0.33
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy 0.08
Pre-rRNA spatial distribution and functional organization of the nucleolus 0.35
RNA codon expansion via programmable pseudouridine editing and decoding 0.10
3 0.95
Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease 0.53
Democratizing protein language model training, sharing and collaboration 0.07
Scalable secondary metabolite production in Streptomyces using a plug-and-play system 0.36
2 0.36
A transport-independent role for SLC25A12 in mitochondrial stress signalling 0.25
DNA nanodevices detect an acidic nanolayer on the lysosomal surface 0.11
3 0.31
Adhesion GPCR-induced ectocytosis mediates intercellular GPCR signal propagation 0.08
Photo-cross-linking-assisted deorphanization deciphers GPR50–L-LEN pairing in metabolism 0.13
Protein β--glucosylation by LtpM through short consensus sequons G-T/S and S-G 0.10
1 0.29
Pseudokinases can catalyse peptide cyclization through thioether crosslinking 0.29
56 12.22
Cryo-EM Structure of the TRPC1/5 Heteromer Enables Design of Antidepressant and Anxiolytic Drug with Reduced Side Effects 0.04
DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes 0.03
Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease 0.15
Subtype-dependent arrestin engagement of the metabotropic glutamate receptors 0.55
Mining of natural diversity enables efficient and expressible peptide asparaginyl ligases 0.10
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors 0.02
PGC-derived migrasomes couple PGC proliferation with migration 0.11
Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms 0.06
Lipid turnover and GEF recruitment collectively determine Rab5 recruitment and activation during the first step of early endosome formation 0.54
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers 0.04
Atlas of predicted protein complex structures across kingdoms 0.03
Functional and structural basis of a negative allostery within GABA hetero-tetramers 0.33
Calcium-mediated calreticulin-IRE1α interaction drives dynamic fluctuation of IRE1α activity under chronic endoplasmic reticulum stress 0.15
A model for drug transport across two membranes of Gram-negative bacteria by an MFS tripartite assembly 0.24
Structural and mechanistic insights into the dual-nuclease defense protein Upx as an anti-phage system 0.22
Rab14 restricts pathogens by promoting V-ATPase lysosomal delivery to drive lysosomal acidification 0.60
Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT 0.04
DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence 0.20
Interpretable and generative deep learning models explicate phase separating intrinsically disordered motifs 0.03
Molecular mechanisms of flotillin complexes in organizing membrane microdomains 0.13
TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience 0.22
-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release 0.22
Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus 0.23
ARMH4 accelerates aging by maintaining a positive-feedback growth signaling circuit 0.04
Conversion of N2 into oxadiazoles promoted by a multinuclear samarium complex 0.55
Understanding interspecies drug response variations between human and rodent P2X7 receptors 0.16
Structural basis of menaquinone reduction by succinate dehydrogenase from Chloroflexus aurantiacus 0.06
In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity 0.80
Mechanical confinement induces ferroptosis through mitochondrial dysfunction 0.11
Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells 0.24
GABA-independent activation of GABAB receptor by mechanical forces 0.06
Structural insights into antagonist recognition by the vasopressin V2 receptor 0.25
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging 0.09
A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly 0.28
Structural mechanism of the agonist binding on human TRPC3 channel 0.24
Cetacean loss of the master adipose tissue regulator β3-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal 0.23
A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis 0.05
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes 0.07
Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins 0.48
Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration 0.01
Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid 0.22
A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli 0.43
A reconfigurable piezo-ionotropic polymer membrane for sustainable multi-resonance acoustic sensing 0.31
Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation 0.10
Fishing out AIEC with FimH capturing microgels for inflammatory bowel disease treatment 0.27
Dual mitotic bookmarking by GAF and H3K27ac orchestrates differential propagation of cell fate memory in neural development 0.32
Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores 0.07
Molecular insights of acarbose metabolization catalyzed by acarbose-preferred glucosidase 0.69
Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection 0.09
A covalent organic framework membrane with highly selective and permeable artificial sodium channels via ion recognition 0.04
Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification 0.63
An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity 0.07
Biomimetic synthesis of vesicular covalent organic frameworks by gemini surfactants for in-situ enzyme cascade immobilization 0.25
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates 0.02
Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation 0.54
ROMO1 overexpression protects the mitochondrial cysteinome from oxidations in aging 0.20
1 0.16
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response 0.16
2 0.47
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques 0.31
Integrating diverse experimental information to assist protein complex structure prediction by GRASP 0.17
1 0.10
An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing 0.10
1 0.90
Decoding frequency-modulated signals increases information entropy in bacterial second messenger networks 0.90
2 1.06
Structural basis of PTH1R–β-arrestin core engagement reveals design principles for G-protein-biased therapeutics 0.42
Ligand binding modes of the bitter taste receptor T2R14 and T2R46 0.64
2 0.58
Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis 0.07
Structural insights into the activation of TMEM175 by small molecule 0.52
1 0.08
The transcription factor SKN-1 drives lysosomal enlargement during aging to maintain function 0.08
24 6.53
Decoding the structure of GPR151 via NELiS 0.37
Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design 0.33
Physiological super-resolution in situ recording reveals kinetic changes of sympathetic norepinephrine release in heart failure 0.11
Plant pathogenic nematode exosomes remodel vector tracheae to enhance pathogen transmission 0.47
Absolute hand determination of glycofibrils from natural sources in cryo-EM 0.03
PLETHORA–autophagy axis activates organ regeneration through ROS modulation 0.14
A class of COPI cargo receptors regulates processing of transmembrane proteins by reinforcing their Golgi retention 0.37
Spatially regulated mRNA translation enables functional membrane protein integration in synthetic cells 0.59
Flexible protein–ligand docking with diffusion-based side-chain packing 0.45
Controllable gap junctions by vitamin B12 and light 0.08
Structural insights into nonpeptide antagonist inhibition of somatostatin receptor subtype 5 0.47
<atl>Preassembly and independent trafficking of the exocyst complex in iArabidopsis/i</atl> 0.06
Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration 0.05
Extracellular nanobody screening using conformationally stable GPCR variants 0.07
Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival 0.01
GeoEvoBuilder: A deep learning framework for efficient functional and thermostable protein design 0.35
Binding of Fusobacterium nucleatum autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion 0.40
Aspartic acid residues in BBE-like enzymes from Morus alba promote a function shift from oxidative cyclization to dehydrogenation 0.23
The fetal hydrops–associated single-residue mutation L322P disrupts mechanical but not chemical activation of the PIEZO1 ion channel 0.09
Time-resolved photocatalytic proximity labeling uncovers ER proteome dynamics underlying UPR-to-apoptosis transition 0.38
De novo design of a fusion protein tool for GPCR research 0.09
Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Ighm) as a tissue-level aging biomarker 0.64
Cryo-EM structures of GnRHR: Foundations for next-generation therapeutics 0.67
Synthetic models of the nitrogenase FeMo cofactor 0.08
5 2.08
Structural N- and O-glycans revealed by high-resolution cryo-EM analysis of tubular mastigonemes 0.30
Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1 0.33
Glycolysis-compatible urethanases for polyurethane recycling 0.47
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling 0.19
Molecular evolution of sour tolerance in birds 0.79
9 3.05
mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy 0.58
Covalent capture and genetic code expansion enables chemoproteomic profiling and functional characterization of lysine acetoacetylation 0.27
Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation 0.03
Direct trapping of the transport-segment DNA by the central domain of type IIA topoisomerases 0.64
Dynamic structures of a membrane transporter in native cellular membranes 0.43
Mechanical contribution of germ cell specification in Arabidopsis anthers 0.16
Physics-informed deep learning for plasmonic sensing of nanoscale protein dynamics in solution 0.45
A sensory and motor neuropathy caused by a genetic variant of NAMPT 0.03
Ion channel structure and function of the MERS coronavirus E protein 0.44
2 0.61
Structural insight into ligand binding and activation of the orphan GPCR Mas1 0.57
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion 0.04
1 0.14
Inositol phosphates as an overlooked phosphorous source in marine ecosystems 0.14
1 0.78
Substrate specificity and transport mechanism of the chloroplast dicarboxylate transporters DiT1 and DiT2 0.78

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