Bioinformatics and Computational Biology articles for Netherlands

Time frame: 1 June 2025 - 30 May 2026

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Count: 147

Article ‘Count’ for Bioinformatics and Computational Biology.

Journal Count Share
3 0.40
A next-generation episignature for Kabuki syndrome enables fine mapping of the impact of KMT2D variants to inform precision medicine 0.11
Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues 0.25
Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits 0.04
12 6.19
A Prototype timsOmni Platform Enables Confident Annotation of the Key Hypervariable CDR3 Regions of IgG Immunoglobulins Using Low- and High-Energy Electron-Based Fragmentation 0.46
Direct Infusion Acoustic Droplet Ejection Mass Spectrometry: Enabling High-Throughput Shotgun Lipidomics 0.67
Comparison of Liquid Chromatography- and Nano-Electrospray Ionization-Mass Spectrometry Approaches for Single-Cell Metabolomics 0.13
Intrinsic N-Terminal Reactivity and Improved Analysis of DSSO-Carbamate and Carbamate-Based Cross-Linkers 0.05
Measurable Feature Prediction for Estimating Chemical Space Coverage in LC–ESI–HRMS Nontargeted Analysis 0.93
Benchmarking Lysosome Enrichment Methods: A Guide for Research and Clinical Translation 0.88
Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N-Glycoproteome 0.71
Proteomic Profiling of Urinary Large Extracellular Vesicles for the Diagnosis of Prostate Cancer 0.09
Machine Learning for Enhanced Identification Probability in RPLC/HRMS Nontargeted Workflows 0.50
Development of a Robust Platform for Infrared Ion Spectroscopy: A New Addition to the Analytical Toolkit for Enhanced Metabolite Structure Elucidation 0.63
Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset 0.15
Nanoflow Size Exclusion Chromatography–Native Mass Spectrometry of Intact Proteoforms and Protein Complexes 1.00
1 0.09
Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet? 0.09
2 0.57
A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases 0.53
Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes 0.05
2 1.06
Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers 1.00
Array Genotyping of Transfusion Relevant Blood Cell Antigens in 6946 Ancestrally Diverse Subjects 0.06
4 1.76
IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma 0.94
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma 0.00
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer 0.04
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets 0.77
5 0.95
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome 0.06
The evolution of high-order genome architecture revealed from 1,000 species 0.02
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants 0.76
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions 0.08
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids 0.03
3 1.17
Population structure and domestication history of the Javan banteng 0.04
Extensive horizontal transfer of transposable elements shapes fungal mobilomes 1.00
Whole-genome sequences provide insights into the formation and adaptation of human populations in the Himalayas 0.13
1 0.11
Gene Family Expansions Provide Molecular Flexibility Required for Context‐Dependent Species Interactions 0.11
3 0.48
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure 0.23
<atl>Automated patch clamp data improve variant classification and penetrance stratification for iSCN5A/i –Brugada syndrome</atl> 0.15
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease 0.10
2 1.30
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer 1.00
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci 0.30
2 0.05
The SeqSplice multiplexed minigene splicing assay for characterization and quantitation of variant-induced BRCA1 and BRCA2 splice isoforms 0.04
Highly accurate assembly polishing with DeepPolisher 0.01
2 1.03
Two CTCF motifs impede cohesin-mediated DNA loop extrusion 0.70
Cryo-EM reveals open and closed Asgard chromatin assemblies 0.33
5 1.79
Within- and between-family genetic effects on educational achievement vary across countries and ages 0.04
Identification of SENP7 and UTF1/VENTX as new loci influencing clustered protocadherin methylation across blood and brain using a genome-wide association study 0.67
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa 0.05
Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits 1.00
Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up 0.03
9 2.51
Distinct genetic architecture in the tails of complex traits 0.08
Pervasive and programmed nucleosome distortion on single chromatin fibres 0.09
Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion 0.32
Regulatory grammar in human promoters uncovered by MPRA-based deep learning 1.00
An integrated view of the structure and function of the human 4D nucleome 0.04
Mapping the genetic landscape across 14 psychiatric disorders 0.04
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples 0.86
Complex genetic variation in nearly complete human genomes 0.01
Structural variation in 1,019 diverse humans based on long-read sequencing 0.06
1 1.00
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation 1.00
37 10.12
Large-scale analysis of temporal gene expression variation in peripheral blood 0.00
Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries 0.12
Genome reshaping by Helitron transposons in Fusarium oxysporum TR4 affects secondary metabolism but not virulence 0.80
Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning 1.00
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion 0.00
SpatialCOC: an integrative framework for spatial continuous mapping and cross-omics correction in spatial multi-omics data 0.03
TONSL suppresses polymerase theta-dependent tandem duplications through chromatin-guided repair 1.00
An integrated germline and somatic genomic model for coronary artery disease 0.01
An international multi-centre study to develop and validate federated learning-based prognostic models for anal cancer 0.12
Genetic modifiers of -ε4-associated cognitive decline 0.00
Cross ionization mode chemical similarity prediction between tandem mass spectra in metabolomics 0.21
Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping 0.02
BiG-SCAPE 2.0 and BiG-SLiCE 2.0: scalable, accurate and interactive sequence clustering of metabolic gene clusters 0.63
Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics 0.09
Genetic and non-genetic factors distinctly shape the variation of the immune response in cattle 0.06
The biomedical landscape of genomic structural variation in the qatari population 0.04
Global solidarity in genomic surveillance improves early detection of acute respiratory virus threats 0.59
A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry 0.08
PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias 0.88
Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation 0.17
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology 0.13
Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study 0.04
Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1 0.08
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus 0.14
Benchmarking scRNA-seq copy number variation callers 0.29
The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression 0.03
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking 0.37
DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins 0.50
Local genetic sex differences in quantitative traits 1.00
Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions 0.16
Machine learning in Alzheimer’s disease genetics 0.08
Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction 0.72
The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness 0.44
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets 0.02
MR-link-2: pleiotropy robust Mendelian randomization validated in three independent reference datasets of causality 0.19
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins 0.06
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses 0.02
14 2.28
Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations 0.01
Empirically determined baseline masking strategies and other considerations for gene-level burden tests 0.18
Population-level structural variant characterization using pangenome graphs 0.05
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification 0.04
Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk 0.03
Characterization of induced cohesin loop extrusion trajectories in living cells 1.00
Nucleotide dependency analysis of genomic language models detects functional elements 0.13
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes 0.17
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution 0.00
A multi-tissue single-cell expression atlas in cattle 0.03
DNA methylation influences human centromere positioning and function 0.23
LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes 0.25
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize 0.12
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations 0.05
1 0.09
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 0.09
4 1.80
Real-world clinical utility of tumor whole-genome sequencing in solid cancers 0.97
A consensus immune dysregulation framework for sepsis and critical illnesses 0.11
Genetic and molecular landscape of comorbidities in people living with HIV 0.64
Polygenic prediction of body mass index and obesity through the life course and across ancestries 0.08
3 0.04
SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads 0.01
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny 0.02
PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories 0.02
1 0.01
Fine-mapping genomic loci refines bipolar disorder risk genes 0.01
1 0.75
Spontaneous switching in a protein signalling array reveals near-critical cooperativity 0.75
1 1.00
Interactions between the genome and the nuclear lamina are multivalent and cooperative 1.00
3 2.63
Pangenome graph analysis reveals evolution of resistance breaking in spinach downy mildew 1.00
MEANtools integrates multi-omics data to identify metabolites and predict biosynthetic pathways. 0.75
Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis 0.88
5 1.47
Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts 0.10
Simplifying causal gene identification in GWAS loci 0.40
Genetic underpinnings of chills from art and music 0.88
Genome-wide association study provides novel insight into the genetic architecture of severe obesity 0.02
Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. 0.08
1 1.00
Dynamic Self-Loops in Networks of Passive and Active Binary Elements 1.00
7 0.80
Archaeogenetic insights into the demographic history of Late Neanderthals 0.05
Sudan’s complex genetic admixture history drives adaptation to malaria in Sudanese Copts 0.06
Exceedingly low genetic diversity in snow leopards due to persistently small population size 0.01
Targeting the 3D genome by anthracyclines for chemotherapeutic effects 0.43
Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases 0.06
Comparative performance of viral landscape phylogeography approaches 0.11
Convergent expansions of keystone gene families drive metabolic innovation in Saccharomycotina yeasts 0.08
1 0.17
Virtual endocast of the Late Miocene Hoplitomeryx matthei (Artiodactyla, Hoplitomerycidae) and brain evolution in insular ruminants. 0.17
3 1.51
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function 0.19
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments 0.50
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene 0.82
5 2.70
The immunoproteome and multimorbidity: A Mendelian randomization study 0.23
Humpback whale genomes reflect the increased efficiency of commercial whaling 0.38
Evaluating the effects of archaic protein-altering variants in living human adults 1.00
Learning the sequence code of protein expression in human immune cells 1.00
A lipid atlas of the human kidney 0.10
1 0.07
Direct visualization and tracing of chromatin folding in the Drosophila embryo 0.07
1 0.06
Strain-level diversity of giant viruses infecting chlorarachniophyte algae in the subtropical North Pacific 0.06
1 0.18
<atl>Gain and loss of gene function shaped the nickel hyperaccumulation trait in iNoccaea caerulescens/i</atl> 0.18

Numerical information only (in the tables above) is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International.