Bioinformatics and Computational Biology articles for Switzerland

Time frame: 1 May 2025 - 30 April 2026

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Count: 113

Article ‘Count’ for Bioinformatics and Computational Biology.

Journal Count Share
3 2.10
Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues 0.70
LiMA: Robust inference of molecular mediation from summary statistics 1.00
MosCoverY: A method to estimate mosaic loss of Y chromosome from sequencing coverage data 0.40
6 2.41
A Prototype timsOmni Platform Enables Confident Annotation of the Key Hypervariable CDR3 Regions of IgG Immunoglobulins Using Low- and High-Energy Electron-Based Fragmentation 0.08
Automated Online Direct mRNA Sequence Mapping Using Partial RNase T1 Digests 0.20
Untargeted Multiple Reaction Monitoring 0.28
A Flexible End-to-End Automated Sample Preparation Workflow Enables Standardized and Scalable Bottom-up Proteomics 0.69
Identification of Isomeric Metabolites Using Cold Ion Spectroscopy Add-on to Orbitrap-Based Mass Spectrometer 0.67
General Screening and Multiple Dissociation Methods for Complementary LC–MS Analysis of Pesticides in Beverages: Potential and Pitfalls 0.50
1 0.14
Bifunctional Probes Reveal the Rules of Intracellular Ether Lipid Transport 0.14
1 0.01
Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis 0.01
3 0.24
A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases 0.18
Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes 0.05
Genetics of Childhood‐onset Systemic Lupus Erythematosus (cSLE) 0.02
1 0.02
Array Genotyping of Transfusion Relevant Blood Cell Antigens in 6946 Ancestrally Diverse Subjects 0.02
1 0.06
Whole-genome sequences provide insights into the formation and adaptation of human populations in the Himalayas 0.06
1 0.04
Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention. 0.04
1 0.06
A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change 0.06
5 2.60
Robust and efficient annotation of cell states through gene signature scoring 0.82
Early feature extraction drives model performance in high-resolution chromatin accessibility prediction 0.94
BayesRVAT enhances rare-variant association testing through Bayesian aggregation of functional annotations 0.07
Unveiling the functional fate of duplicated genes through expression profiling and structural analysis 0.73
Common cis-regulatory variation modifies the penetrance of pathogenic SHROOM3 variants in craniofacial microsomia 0.04
1 0.09
Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes 0.09
1 0.95
Deep biochemical phenotyping reveals prognostic value of rare genetic variants in adult kidney stone disease 0.95
1 0.02
A Plasma Metabolic Signature to Diagnose Pulmonary Tuberculosis and Monitor Treatment Response 0.02
1 0.20
Root cause discovery via permutations and Cholesky decomposition 0.20
4 2.94
Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption 0.18
The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 0.83
Chromatin-dependent motif syntax defines differentiation trajectories 0.93
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states 1.00
1 0.01
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa 0.01
10 2.63
Transposable elements are driving rapid adaptation of Enterococcus faecium 0.08
The evolutionary history and unique genetic diversity of Indigenous Americans 0.01
Mapping the genetic landscape across 14 psychiatric disorders 0.01
Efficient and accurate search in petabase-scale sequence repositories 1.00
A haplotype-based evolutionary history of barley domestication 0.06
One mother for two species via obligate cross-species cloning in ants 0.03
Parent-of-origin effects on complex traits in up to 236,781 individuals 0.21
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates 0.19
Pathology-oriented multiplexing enables integrative disease mapping 0.04
Multigenerational cell tracking of DNA replication and heritable DNA damage 1.00
2 0.75
Computational prediction of human genetic variants in the mouse genome 0.25
Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation 0.50
1 0.69
LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis 0.69
35 14.37
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients 0.02
HaploC-tools reveal haplotype-specific chromosome conformation and chromatin states 1.00
Genetic architecture of lumbar spinal stenosis 0.01
Solubility based mechanistic profiling of combinatorial drug therapy 0.08
LysG-driven transcriptional network rewiring underlies lineage-specific phenotypes in Mycobacterium tuberculosis 0.81
Exon inclusion signatures enable accurate estimation of splicing factor activity 0.14
Mechanisms of gene regulation by SRCAP and H2A.Z 0.38
Electrostatic properties of disordered regions control transcription factor search and pioneer activity 1.00
Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations 0.08
Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping 0.04
Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics 0.03
Global solidarity in genomic surveillance improves early detection of acute respiratory virus threats 0.04
Temporal constraints on enhancer usage shape the regulation of limb gene transcription 1.00
Rad51 determines pathway usage in post-replication repair 0.13
Chromosome-level haplotype-resolved assembly of highly heterozygous grass genomes with PhaseGrass 0.43
Identification of a deep-branching lineage of algae using environmental plastid genomes 0.25
Cohesin forms fountains at active enhancers in C. elegans 0.77
RoCK and ROI: single-cell transcriptomics with multiplexed enrichment of selected transcripts and region-specific sequencing 0.68
Compressed sensing expands the multiplexity of imaging mass cytometry 1.00
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology 0.38
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen 1.00
Widespread reveals hidden diversity and reshapes understanding of human whipworm infections 0.60
Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1 0.92
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus 0.02
Uncovering hidden enhancers through unbiased in vivo testing 0.04
Machine learning in Alzheimer’s disease genetics 0.01
Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells 0.63
MR-link-2: pleiotropy robust Mendelian randomization validated in three independent reference datasets of causality 0.07
ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets 0.19
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins 0.03
A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy 0.50
Depletion-dependent activity-based protein profiling using SWATH/DIA-MS detects serine hydrolase lipid remodeling in lung adenocarcinoma progression 1.00
Auricular malformations are driven by copy number variations in a hierarchical enhancer cluster and a dominant enhancer recapitulates human pathogenesis 0.04
Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline 0.56
Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity 0.52
7 1.62
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification 0.04
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion 0.10
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models 0.04
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq 0.83
Noncoding rare variant associations with blood traits in 166,740 UK Biobank genomes 0.50
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design 0.10
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations 0.01
4 1.09
Proteomic risk score for early prediction of kidney disease progression in individuals with high-risk genotypes 0.08
Polygenic prediction of body mass index and obesity through the life course and across ancestries 0.01
Deep phenotyping of health–disease continuum in the Human Phenotype Project 0.03
Feasibility of multiomics tumor profiling for guiding treatment of melanoma 0.97
4 2.05
Resolving sensitivity, specificity and signal contamination in Xenium spatial transcriptomics 1.00
Unified mass imaging maps the lipidome of vertebrate development 1.00
Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing 0.03
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics 0.02
1 0.00
Fine-mapping genomic loci refines bipolar disorder risk genes 0.00
1 0.08
Spontaneous switching in a protein signalling array reveals near-critical cooperativity 0.08
2 1.16
Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom 1.00
Population genomics and molecular epidemiology of wheat powdery mildew in Europe. 0.16
1 0.03
Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. 0.03
1 1.00
Out-of-Equilibrium Selection Pressure Enhances Inference from Protein Sequence Data 1.00
5 1.56
A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals 0.05
Earliest perissodactyls reveal large-scale dispersals during the PETM 0.33
Sex-allocation trade-offs and their genetic architecture revealed by experimental evolution 1.00
Deep evolutionary conservation of a sex-determining locus without sequence homology 0.06
Patient stratification reveals the molecular basis of disease co-occurrences 0.13
1 0.17
Virtual endocast of the Late Miocene Hoplitomeryx matthei (Artiodactyla, Hoplitomerycidae) and brain evolution in insular ruminants. 0.17
2 0.57
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis 0.37
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments 0.20
3 1.41
Soma-derived 30-nt small RNAs are coupled with chromosome breakage and precisely target nontransposon DNA against elimination in Euplotes vannus 0.21
Indirect genetic effects among neighbors promote cooperation and accelerate adaptation in a small-scale human society 0.20
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes 1.00
1 0.30
Redox gradients define the ecological niche of ciliates with denitrifying endosymbionts in anoxic lake waters 0.30

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