Bioinformatics and Computational Biology articles for United Kingdom (UK)

Time frame: 1 June 2025 - 30 May 2026

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Count: 349

Article ‘Count’ for Bioinformatics and Computational Biology.

Journal Count Share
9 3.66
Neurodevelopmental copy-number variants increase risk of internalizing and cardiometabolic multimorbidity: Findings from the UK Biobank 1.00
Genetics of skeletal proportions across two different populations 0.29
Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution 0.86
SPINK1-related chronic pancreatitis: A model that encapsulates the spectrum of variant effects, genetic complexity, and classificatory challenges 0.09
Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyere 0.14
A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia 0.04
Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets 0.05
Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits 0.33
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists 0.85
26 13.82
Determination from Nontargeted Metabolite Profiling Using Internal and External Standards 0.02
Pitfalls and Inherent Biases in Liquid Handling Robotics: Investigations in Automation for SI Traceable Measurements 1.00
Lipid Class Prediction from MS1 Data using Gaussian Graphical Models 0.63
General Nuclear Magnetic Resonance Analysis Toolbox for Stats: A Comprehensive Module for Nuclear Magnetic Resonance-Based Chemometrics and Metabolomics 0.71
Best Practices in GC–MS and GC × GC–MS-Based Metabolomics and Volatile Analyses: An International Survey 0.10
A Universal Framework for Blood Ionome Extraction and Intelligent Quality Control in 1H NMR Metabolomics 0.21
CASMDB: An Open-Source Database of Metabolite Annotation Data for 1D 1H NMR-Based Metabolomics 1.00
Automated Online Direct mRNA Sequence Mapping Using Partial RNase T1 Digests 0.80
Comparison of Liquid Chromatography- and Nano-Electrospray Ionization-Mass Spectrometry Approaches for Single-Cell Metabolomics 0.88
Untargeted Multiple Reaction Monitoring 0.06
Challenges and Good Practices in Preprocessing and Normalization of Untargeted DNA Adductomics Data in Exposomics Research 0.04
Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N-Glycoproteome 0.14
Imaging of Protein Assemblies up to 231 kDa in Tissues with Nano-DESI Mass Spectrometry 1.00
Resolution-Adaptive Binning Enhances Machine Learning Modeling by Interbatch and Multiplatform Orbitrap-Based Shotgun Mass Spectrometry Data Integration 0.05
Adaptive Modeling of Tandem Mass Spectrometry Data: Creation of the METLIN 960K MRM Database 0.13
Investigating a Systematic and Widespread Misidentification in the Metabolic Profiling Literature: Phenylacetylglutamine and Phenylacetylglycine Signal Misassignment in Proton NMR Spectra of Human and Rodent Urine 0.42
Formic Acid Pretreatment Enhances Untargeted Serum and Plasma Metabolomics 1.00
A Flexible End-to-End Automated Sample Preparation Workflow Enables Standardized and Scalable Bottom-up Proteomics 0.31
A New Approach to Large Multiomics Data Integration 0.82
Deep Structural Characterization of Protein-Bound Lipids via Native MS and Ultraviolet Photodissociation 1.00
Exploring the Potential of Chemically Matched Fragments as Internal Standards for Quantitative SERS with Panobinostat 0.50
MAMSI: Integration of Multiassay Liquid Chromatography–Mass Spectrometry Metabolomics Data Using Multiview Machine Learning 1.00
Low-Cost Heating Modalities Allow the Detection of Biomarkers for Plant Infection Using Rapid Evaporative Ionization Mass Spectrometry (REIMS) That Are Pathogen Specific 1.00
Single-Cell Lipidomics by LC-MS Interlaboratory Study Reveals the Impact of X-ray Irradiation on a Pancreatic Cancer Cell Line and Its Bystanders 0.80
Quantitative Assessment of a Novel Device Designed for Patient-centric Sampling of Dried Plasma Using Targeted Proteomics 0.17
Dual-Drive Platform Combining Biotransformation Prediction and Diagnostic Ion Cluster Reveals Novel Type B Trichothecenes in Wheat 0.05
2 0.19
Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis 0.10
Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes 0.09
1 0.45
Array Genotyping of Transfusion Relevant Blood Cell Antigens in 6946 Ancestrally Diverse Subjects 0.45
2 0.67
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma 0.01
Gene context drift identifies drug targets to mitigate cancer treatment resistance 0.67
2 0.61
Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm 0.50
Combining Spatial Transcriptomics, Pseudotime, and Machine Learning Enables Discovery of Biomarkers for Prostate Cancer 0.11
9 1.81
RegVelo: Gene-regulatory-informed dynamics of single cells 0.29
AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology 0.04
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome 0.28
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants 0.06
Ancient RNA expression profiles from the extinct woolly mammoth 0.05
Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status 0.04
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions 0.92
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance 0.07
Human-specific gene expansions contribute to brain evolution 0.06
2 1.76
Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry 1.00
Transfer learning enables discovery of sub-micromolar antibacterials for ESKAPE pathogens from ultra-large chemical spaces 0.76
1 0.03
High-throughput Proteomics in Lymphangioleiomyomatosis: PMEL as a Diagnostic Biomarker, Construction of a Diagnosis Score and Evidence of Neutrophil Involvement. 0.03
1 0.08
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. 0.08
6 2.80
A transitional, early Cambrian species bridges radiodonts and upper stem-group euarthropods 0.18
Compound starch granule formation in grass seeds is associated with distinct temporal patterns of gene expression 0.75
Robust termite phylogenies built using transposable element composition and insertion events 0.10
Constraints on chromosome evolution revealed by the 229 chromosome pairs of the Atlas blue butterfly 0.83
Whole-genome sequences provide insights into the formation and adaptation of human populations in the Himalayas 0.44
A new Cambrian stem-group echinoderm reveals the evolution of the anteroposterior axis 0.50
1 0.95
A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation 0.95
1 0.21
Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention. 0.21
2 0.07
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure 0.03
<atl>Automated patch clamp data improve variant classification and penetrance stratification for iSCN5A/i –Brugada syndrome</atl> 0.04
1 0.26
Temporal loss of En1 during limb development causes distinct phenotypes 0.26
7 1.68
Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity 0.18
Analysis of coding gene expression from small RNA sequencing 1.00
ERC2.0 evolutionary rate covariation update improves inference of functional interactions across large phylogenies 0.11
Unveiling the functional fate of duplicated genes through expression profiling and structural analysis 0.07
The SeqSplice multiplexed minigene splicing assay for characterization and quantitation of variant-induced BRCA1 and BRCA2 splice isoforms 0.08
Highly accurate assembly polishing with DeepPolisher 0.09
Verkko2 integrates proximity-ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding 0.14
2 1.15
Large-scale analysis of FMR1 CGG repeat length and risk of premature ovarian insufficiency in over 92 000 women 1.00
Stratifying IVF population endometria using a prognosis gradient independent of endometrial timing 0.15
1 0.63
A Mendelian randomization study of the effect of body mass index on 52 causes of death among 125 000 Mexican adults with admixed ancestry 0.63
1 0.21
Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores 0.21
3 1.59
Biomarkers of Insulin Resistance and Their Performance as Predictors of Treatment Response in Overweight Adults 0.50
Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study 1.00
Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes 0.09
2 0.35
Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver Syndrome 0.06
Gene-environment interactions modulate the phenotypic severity in mouse models of congenital craniofacial syndromes 0.29
1 0.01
Molecular-Based Ecosystem to Improve Personalized Medicine in Chronic Myelomonocytic Leukemia. 0.01
2 1.29
Bifunctional Lipid–Protein Cross-linking Efficiency and Reaction Products 0.29
Integrated Native Mass Spectrometry Imaging of Soluble and Membrane Proteins 1.00
1 0.14
Nephrotic syndrome genomic discovery in the Mass General Brigham Biobank identifies monoallelic MEFV variants as a risk factor for focal segmental glomerulosclerosis 0.14
2 1.10
Sequential verification of transcription by Integrator and Restrictor 1.00
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability 0.10
6 0.85
Genetic investigation of the association between maternal dietary patterns and offspring ADHD 0.11
Within- and between-family genetic effects on educational achievement vary across countries and ages 0.21
Identification of SENP7 and UTF1/VENTX as new loci influencing clustered protocadherin methylation across blood and brain using a genome-wide association study 0.33
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa 0.09
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study 0.06
Genomic risk prediction for depression in a large prospective study of older adults of European descent 0.05
25 8.05
Accelerating scientific discovery with Co-Scientist 0.04
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup 0.02
Telomere-to-Telomere Assembly Using HERRO-Corrected Simplex Nanopore Reads 0.40
Chromosomal fusions trigger rediploidization of autopolyploid genomes 0.04
Saturation editing of reveals distinct dominant and recessive disorders 0.20
A disease model resource reveals core principles of tissue-specific cancer evolution 0.16
Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion 0.13
Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes 0.64
Efficient near-telomere-to-telomere assembly of nanopore simplex reads 0.50
Advancing regulatory variant effect prediction with AlphaGenome 1.00
Insights into DNA repeat expansions among 900,000 biobank participants 0.11
An integrated view of the structure and function of the human 4D nucleome 0.01
Mapping the genetic landscape across 14 psychiatric disorders 0.05
Estimation and mapping of the missing heritability of human phenotypes 0.03
Assessing phylogenetic confidence at pandemic scales 0.60
Evidence for improved DNA repair in long-lived bowhead whale 0.04
Sperm sequencing reveals extensive positive selection in the male germline 1.00
Somatic mutation and selection at population scale 1.00
Hotspots of human mutation point to clonal expansions in spermatogonia 0.29
Clone copy number diversity is linked to survival in lung cancer 0.98
Whole-genome sequencing of 490,640 UK Biobank participants 0.55
Structural variation in 1,019 diverse humans based on long-read sequencing 0.14
Complex genetic variation in nearly complete human genomes 0.04
Cryptic variation fuels plant phenotypic change through hierarchical epistasis 0.08
Ancient DNA reveals a two-clanned matrilineal community in Neolithic China 0.02
5 2.08
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles 0.01
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors 0.97
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap 0.83
Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation 0.21
Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases 0.06
3 1.24
Lipid-trap mass spectrometry identifies lipid–protein interactions in cells 1.00
LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis 0.15
TemporalVAE: atlas-assisted temporal mapping of time-series single-cell transcriptomes during embryogenesis 0.08
107 43.51
Evaluating confounding in rare variant genome wide association studies 0.95
Large-scale analysis of temporal gene expression variation in peripheral blood 0.13
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain 0.67
Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation 1.00
Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy 0.06
Nicotine biosynthesis is completed by cryptic activating glucosylation 0.73
Dissecting epigenetic heterogeneity in single-cell DNA methylomes with a unified framework 0.25
Global-scale population genetic analysis of Plasmodium falciparum identifies region-specific patterns of malaria parasite adaptation 0.54
Extensive antagonistic variants across the human genome 0.13
Genetic landscape of adult executive function reveals a cell-type-specific developmental origin 0.88
SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration 0.05
Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk 1.00
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients 0.01
TUSCO: benchmarking transcriptome reconstruction with endogenous single-isoform controls 0.17
Horizontal gene transfer and diploidy illuminate evolution and stress adaptation in oleaginous Scenedesmaceae (Chlorophyta) 0.14
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion 0.08
Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32 1.00
The adaptive molecular landscape of reprogrammed telomeric sequences 0.05
Scaling up Bayesian population phylogenomics through virtual dimension reduction 0.40
African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children 0.49
Genetic architecture of lumbar spinal stenosis 0.05
The global phylogeography of rapidly expanding multidrug resistant Ural lineage 4.2 Mycobacterium tuberculosis 0.05
LysG-driven transcriptional network rewiring underlies lineage-specific phenotypes in Mycobacterium tuberculosis 0.04
Celcomen: spatial causal disentanglement for single-cell and tissue perturbation modeling 0.83
Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome 0.13
An international multi-centre study to develop and validate federated learning-based prognostic models for anal cancer 0.36
Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis 0.64
Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions 0.07
Context-specific regulatory genetic variation in dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis 1.00
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries 0.02
Genetic modifiers of -ε4-associated cognitive decline 0.01
KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans 0.27
A catalogue of early diverged contemporary human genome variation reveals distinct Khoe-San populations 0.03
Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity 0.58
Cross ionization mode chemical similarity prediction between tandem mass spectra in metabolomics 0.14
Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations 0.92
Integrative functional genomics analysis identifies pleiotropic genes for vascular diseases 0.48
AI-based multiomics profiling reveals complementary omics contributions to personalized prediction of cardiovascular disease 0.06
Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping 0.02
The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex prediction 0.02
Cross-ancestry comparison of aptamer and antibody protein measures 0.02
Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics 0.18
Preventing premature deaths through polygenic risk scores 0.83
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility 0.09
The biomedical landscape of genomic structural variation in the qatari population 0.11
Pulsed evolution shaped extant angiosperm pollen disparity 0.13
Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies 0.38
VACmap: an accurate long-read aligner for unraveling complex genomic rearrangements 0.44
Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions 0.44
The Health for Life in Singapore (HELIOS) Study: delivering precision medicine research for Asian populations 0.11
Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations 0.67
Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cells 0.18
Cross-platform clinical proteomics using the Charité open standard for plasma proteomics (OSPP) 0.07
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma 0.92
Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data 0.77
Flexible read-aware genotype imputation from sequence using biobank sized reference panels 0.33
Cohesin forms fountains at active enhancers in C. elegans 0.08
CiFi: accurate long-read chromosome conformation capture with low-input requirements 0.27
Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits 0.03
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome 0.71
Expanding the utility of variant effect predictions with phenotype-specific models 0.27
Insights into natural neocentromere evolution from a cattle T2T X chromosome 0.20
Enabling whole genome sequencing analysis from FFPE specimens in clinical oncology 0.09
Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation 0.58
Addressing the specific roles of histone modifications in transcriptional repression 0.45
Integration of metagenome-assembled genomes with clinical isolates expands the genomic landscape of gut-associated Klebsiella pneumoniae 1.00
PLM-interact: extending protein language models to predict protein-protein interactions 1.00
The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities 0.17
A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images 0.95
Integrating cross-sample and cross-modal data for spatial transcriptomics and metabolomics with SpatialMETA 0.13
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus 0.13
Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis 0.06
Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort 0.04
Genetic determinants of monocyte splicing are enriched for disease susceptibility loci 1.00
The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression 0.05
Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes 1.00
Shared genetic architecture contributes to risk of major cardiovascular diseases 0.06
Genetic architecture of plasma metabolome in 254,825 individuals 0.03
CLADES: a hybrid NeuralODE-Gillespie approach for unveiling clonal cell fate and differentiation dynamics 0.67
Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases 0.96
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking 0.04
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells 0.50
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells 0.13
Substrate accessibility regulation of human TopIIa decatenation by cohesin 1.00
Whole-exome sequencing analysis identifies risk genes for schizophrenia 1.00
Causal mediation analysis for time-varying heritable risk factors with Mendelian randomization 0.25
Machine learning in Alzheimer’s disease genetics 0.10
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ 0.18
Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction 0.17
The mitotic chromosome periphery modulates chromosome mechanics 1.00
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets 0.21
Nucleosome spacing can fine-tune higher-order chromatin assembly 0.31
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes 1.00
MR-link-2: pleiotropy robust Mendelian randomization validated in three independent reference datasets of causality 0.16
Phylogenetically informed predictions outperform predictive equations in real and simulated data 0.75
Machine learning-assisted decoding of temporal transcriptional dynamics via fluorescent timer 0.10
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses 0.03
Prosit-XL: enhanced cross-linked peptide identification by fragment intensity prediction to study protein interactions and structures 0.04
Transcripts with high distal heritability mediate genetic effects on complex metabolic traits 0.04
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins 0.19
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis 1.00
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer 0.94
Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy 0.87
GPerturb: Gaussian process modelling of single-cell perturbation data 1.00
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding 0.95
Faster adaptation but slower divergence of X chromosomes under paternal genome elimination 0.57
Performance of deep-learning-based approaches to improve polygenic scores 0.96
23 6.43
Genome-wide fine-mapping improves identification of causal variants 0.09
Genomic, phenomic and geographic associations of leukocyte telomere length in the United States 0.19
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity 0.60
Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila 0.44
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification 0.01
Linking the plasma proteome to genetics in individuals from continental Africa provides insights into type 2 diabetes pathogenesis 0.07
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion 0.07
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction 0.08
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models 0.07
Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease 0.05
Complete genome assemblies of two mouse subspecies reveal structural diversity of telomeres and centromeres 0.56
Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health 0.65
A genetic map of human metabolism across the allele frequency spectrum 0.27
Limited overlap between genetic effects on disease susceptibility and disease survival 0.27
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes 0.07
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution 0.93
A multi-tissue single-cell expression atlas in cattle 0.05
A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism 0.07
Genome assembly of two allotetraploid cotton germplasms reveals mechanisms of somatic embryogenesis and enables precise genome editing 0.08
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy 0.07
Detecting and quantifying clonal selection in somatic stem cells 0.83
Predicting resistance to chemotherapy using chromosomal instability signatures 0.80
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations 0.08
2 0.38
Ancient DNA evidence for the history of the Albanians 0.13
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 0.25
2 0.14
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes 0.02
Polygenic prediction of body mass index and obesity through the life course and across ancestries 0.12
11 3.63
Systematically decoding pathological morphologies and molecular profiles with unified multimodal embedding 0.20
SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads 0.09
Integration of alternative fragmentation techniques into standard LC-MS workflows using a single deep learning model enhances proteome coverage 0.44
Highly accurate ab initio gene annotation with ANNEVO 0.08
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny 0.20
Rate variation and recurrent sequence errors in pandemic-scale phylogenetics 0.80
Pertpy: an end-to-end framework for perturbation analysis 0.05
Annotating the genome at single-nucleotide resolution with DNA foundation models 0.61
Uncovering hidden protein modifications with native top-down mass spectrometry 1.00
Morphological map of under- and overexpression of genes in human cells 0.07
BEAST X for Bayesian phylogenetic, phylogeographic and phylodynamic inference 0.09
2 0.12
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders 0.02
Fine-mapping genomic loci refines bipolar disorder risk genes 0.11
1 0.15
Enhancer dynamics and cellular architecture in the human spinal cord 0.15
6 2.56
Comparative gene annotation and orthology assignments across 301 species of Drosophilidae 0.38
A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation 0.10
Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia. 1.00
MEANtools integrates multi-omics data to identify metabolites and predict biosynthetic pathways. 0.04
A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations 1.00
Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis 0.04
12 6.40
Simulated sample splitting approach to address biases due to instrument selection and participant overlap in two-sample Mendelian Randomization studies 0.33
Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation 1.00
Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight 0.24
An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank 0.94
Polygenic risk scores and Parkinson’s disease in South Africa advancing ancestry informed disease prediction 0.07
Chromatin state architecture governs transcription factor accessibility across plant genomes 0.33
Effector innovation in genome-reduced phytoplasmas and other host-dependent mollicutes 1.00
Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies 0.67
From individuals to ancestries: Towards attributing trait variation to haplotypes. 1.00
Beyond recombination: Exploring the impact of meiotic frequency on genome-wide genetic diversity 0.33
Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. 0.35
Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures. 0.13
1 1.00
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription 1.00
2 0.19
Genome and Single-Cell Transcriptome Reveal the Evolution of Holoparasitic Plants: A Case Study of Cistanche deserticola 0.13
Dual-Layer Transcriptional-Protein Regulation by HvAP2-12 Represses HvAP2-18 Activity to Fine-Tune Barley Starch Synthesis 0.07
21 10.18
Position-dependent feedback drives scaling and robustness of morphogen gradients 1.00
Parallel algorithms for phylogenetic inference under a structured coalescent approximation 0.14
Simple biological controllers drive the evolution of soft modes 0.07
Convergent evolution increases boron transport through SNPs and tandem duplications at BOR1 and BOR2 in Arabidopsis thaliana 0.17
No evidence that haplodiploidy favors the evolution of eusociality 1.00
A factor integrating transcription and repression of surface antigen genes in African trypanosomes 1.00
Sudan’s complex genetic admixture history drives adaptation to malaria in Sudanese Copts 0.13
RAD51AP1 is a versatile RAD51 modulator 1.00
Unmeasured prior viability selection resolves the paradox of stasis for body size in wild Soay sheep 1.00
Lipidomic profiling of endometrial cancer using desorption electrospray ionization mass spectrometry imaging 0.93
The Kinship Formula: Inferring the numbers of all kin from any structured population projection model 0.25
Proximity to explosive synchronization determines network collapse and recovery trajectories in neural and economic crises 0.18
Procollagen IIA mediates positive feedback control of the mouse cardiogenic transcriptional network 0.13
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades 0.38
NIPBL and STAG1 enable loop extrusion by providing differential DNA–cohesin affinity 0.44
The power of coalescent methods for inferring recent and ancient gene flow in endangered Bactrian camels 0.17
Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming 0.15
Comparative performance of viral landscape phylogeography approaches 0.11
The importance of small-island populations for the long-term survival of endangered large-bodied insular mammals 0.57
Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer 0.98
Participation bias in the estimation of heritability and genetic correlation 0.38
7 3.76
Genomic diversity and selection in the racing greyhound of Great Britain 0.33
Diversification dynamics of the Palaeozoic actinopterygian radiation 1.00
Collagen fingerprinting and sequence analysis provides a molecular phylogeny of extinct Australian megafauna 0.20
Genome divergence between European anchovy ecotypes fuelled by structural variants originating from trans-equatorial admixture 0.08
Variation in temperature but not diet determines the stability of latitudinal clines in tolerance traits and their plasticity. 0.14
Novel stressors and trait variation determine X-linked meiotic drive frequency. 1.00
The metabolic costs of meiotic drive. 1.00
12 3.11
Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load 0.08
Mechanical load inhibits cancer growth in mouse and human hearts 0.01
A deep-time landscape of plant cis-regulatory sequence evolution 0.05
Gapless pangenome analyses reveal fast Brassica rapa subspeciation 0.04
The evolution of gene regulation in mammalian cerebellum development 0.07
High-fidelity human chromosome transfer and elimination 1.00
Multiscale structure of chromatin condensates explains phase separation and material properties 0.16
Earliest oceanic tetrapod ecosystem reveals rapid complexification of Triassic marine communities 0.06
Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2 1.00
A human pan-disease blood atlas of the circulating proteome 0.01
A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness 0.17
<atl>Genomic diversity of the African malaria vector iAnopheles funestus/i</atl> 0.44
10 4.49
The immunoproteome and multimorbidity: A Mendelian randomization study 0.77
Premature transcription termination modulates stochastic gene expression in bacteria 0.67
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells 0.30
Direct observation of Notch signaling–induced transcription hubs mediating gene-expression responses 1.00
Genetic legacy and recent cross of two ancient lineages underlie the rebound of the world’s rarest primate 0.05
Introgressed mitochondrial fragments from archaic hominins alter nuclear genome function in modern humans 0.12
Structural and epistatic regulatory variants cause hallmark white spotting in cattle 0.11
The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy 0.43
Uncovering the regulatory landscape of early human B cell lymphopoiesis and its implications in the pathogenesis of B-ALL 0.04
Combinatorial profiling of multiple histone modifications and transcriptome in single cells using scMTR-seq 1.00
2 2.00
A functional overlap between actively transcribed genes and chromatin insulator elements 1.00
Early coordination of cell migration and cardiac fate determination during mammalian gastrulation 1.00
1 0.04
Bacterial transmission within social groups shapes the underexplored gut microbiome in the lemur Indri indri 0.04

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