Bioinformatics and Computational Biology articles for Harvard University, United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 270

Article ‘Count’ for Bioinformatics and Computational Biology.

Journal Count Share
1 0.93
Engineered Development: Directed Morphogenesis of an Embryonic Heart Tube 0.93
16 3.16
A next-generation episignature for Kabuki syndrome enables fine mapping of the impact of KMT2D variants to inform precision medicine 0.03
Principled measures and estimates of trait polygenicity 0.38
Defining a tandem repeat catalog and variation clusters for genome-wide analyses and population databases 0.13
Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk 0.83
Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies 0.06
Genetics of skeletal proportions across two different populations 0.41
Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues 0.05
The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory 0.02
MIRAGE: A Bayesian statistical method for gene-level rare-variant analysis incorporating functional annotations 0.05
Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program 0.14
Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution 0.09
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies 0.40
Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications 0.25
A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia 0.17
Haplotype analysis reveals pleiotropic disease associations in the HLA region 0.13
Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease 0.02
1 0.11
Genetic Associations with Placental and Pregnancy Proteins in Maternal Serum Identify Biomarkers for Hypertension in Pregnancy 0.11
1 0.08
Best Practices in GC–MS and GC × GC–MS-Based Metabolomics and Volatile Analyses: An International Survey 0.08
1 0.01
Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet? 0.01
2 0.22
Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women 0.21
Array Genotyping of Transfusion Relevant Blood Cell Antigens in 6946 Ancestrally Diverse Subjects 0.02
2 0.37
The NeuroBioBank whole-genome catalogue of human brain donors with central nervous system disorders 0.35
Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer’s disease 0.03
1 0.08
Gene context drift identifies drug targets to mitigate cancer treatment resistance 0.08
2 0.63
BESTDR Enables Bayesian Quantification of Mechanism-Specific Drug Responses. 0.60
Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification 0.03
7 1.30
D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response 0.07
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome 0.02
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance 0.29
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility 0.07
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience 0.23
50,000 years of evolutionary history of India: Impact on health and disease variation 0.03
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue 0.59
1 0.33
Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities 0.33
1 0.08
Transfer learning enables discovery of sub-micromolar antibacterials for ESKAPE pathogens from ultra-large chemical spaces 0.08
1 0.46
High-throughput Proteomics in Lymphangioleiomyomatosis: PMEL as a Diagnostic Biomarker, Construction of a Diagnosis Score and Evidence of Neutrophil Involvement. 0.46
1 0.06
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. 0.06
1 0.13
A Metabolomics Study of Cardiac Dysfunction in Hyperglycemia: Findings From the Atherosclerosis Risk in Communities (ARIC) Study and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) 0.13
1 0.33
Quantitative Exposomics Targeting over 200 Toxicants and Key Biomarkers at the Picomolar Level 0.33
4 0.98
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure 0.01
A polygenic risk score for peripheral artery disease and major adverse limb events 0.85
<atl>Automated patch clamp data improve variant classification and penetrance stratification for iSCN5A/i –Brugada syndrome</atl> 0.08
Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension 0.04
2 0.67
DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development 0.07
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci 0.60
7 1.48
spRefine denoises and imputes spatial transcriptomics with a reference-free framework powered by genomic language model 0.04
Graph-based deep reinforcement learning for haplotype assembly with Ralphi 0.38
Long-read reconstruction of many diverse haplotypes with devider 0.60
ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search 0.25
Multicondition and multimodal temporal profile inference during mouse embryonic development 0.01
Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes 0.17
Highly accurate assembly polishing with DeepPolisher 0.03
1 0.02
Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores 0.02
1 0.02
Drug-Gene Interactions and Clinical Outcomes After Vascular Surgery in the Million Veteran Program 0.02
2 0.38
Association of genetic risk and physical activity with incident type 2 diabetes 0.05
Compartment-Specific Metabolic Alterations to Insulin Reflect Adiposity-Driven Variation and Predict Type 2 Diabetes 0.33
1 0.05
Performance of multiple multi-cancer detection tests using a large independent reference set (Alliance A212102) 0.05
1 0.39
Nephrotic syndrome genomic discovery in the Mass General Brigham Biobank identifies monoallelic MEFV variants as a risk factor for focal segmental glomerulosclerosis 0.39
4 2.79
Mutual antagonism between PRC1 condensates and SWI/SNF in chromatin regulation 1.00
A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence 0.29
Requirements for establishment and epigenetic stability of mammalian heterochromatin 1.00
The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain 0.50
6 0.32
Genetic investigation of the association between maternal dietary patterns and offspring ADHD 0.02
Convergent coexpression reveals shared biological mechanisms underlying common and rare variant risk in six neuropsychiatric disorders 0.24
Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health 0.01
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa 0.01
Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up 0.00
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression 0.04
20 5.26
Mechanism of age-related accumulation of mtDNA mutations in human blood 0.73
Chromosomal fusions trigger rediploidization of autopolyploid genomes 0.01
Ancient DNA reveals pervasive directional selection across West Eurasia 0.50
Saturation editing of reveals distinct dominant and recessive disorders 0.03
Functional dissection of complex trait variants at single-nucleotide resolution 0.27
A disease model resource reveals core principles of tissue-specific cancer evolution 0.01
Single-cell and isoform-specific translational profiling of the mouse brain 0.08
Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion 0.31
Efficient near-telomere-to-telomere assembly of nanopore simplex reads 0.38
Biological insights into schizophrenia from ancestrally diverse populations 0.02
Insights into DNA repeat expansions among 900,000 biobank participants 0.65
An expanded registry of candidate -regulatory elements 0.05
An integrated view of the structure and function of the human 4D nucleome 0.10
Mapping the genetic landscape across 14 psychiatric disorders 0.04
Causal modelling of gene effects from regulators to programs to traits 0.00
Eight millennia of continuity of a previously unknown lineage in Argentina 0.28
Evidence for improved DNA repair in long-lived bowhead whale 0.02
Hotspots of human mutation point to clonal expansions in spermatogonia 0.71
Multiple overlapping binding sites determine transcription factor occupancy 1.00
Complex genetic variation in nearly complete human genomes 0.05
5 1.11
Scoring gene importance by interpreting single-cell foundation models 0.20
Sensitive detection of cancer antigens enabled by user-defined peptide libraries 0.65
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM 0.04
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets 0.04
Tissue and cellular spatiotemporal dynamics in colon aging 0.17
86 18.04
Brieflow: an integrated computational pipeline for high-throughput analysis of optical pooled screening data 0.02
Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy 0.02
Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk 0.07
Decoding spatial transcriptomics across multicellular and subcellular resolutions 0.06
Bridging sequence-structure motifs and genetic variants for genome-wide dynamic RNA-protein interaction profiling 0.10
Local graph estimation with pathwise false discovery control 0.25
Continental-scale genomic surveillance of Plasmodium falciparum malaria across sub-Saharan Africa with rapid nanopore sequencing 0.05
A versatile multi-components mixed model for bacterial-Genome Wide association studies 0.05
Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries 0.02
Admixture-informed polygenic risk reporting using the ePRS framework 0.18
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients 0.03
Early and late RNA eQTL are driven by different genetic mechanisms 0.26
Integrating common and rare variants improves polygenic risk prediction across diverse populations 0.13
Prediction and functional interpretation of inter-chromosomal genome architecture from DNA sequence with TwinC 0.01
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion 0.02
RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions 0.76
Genetic architecture of lumbar spinal stenosis 0.01
Experimental assessment of AI-based interactome mapping 0.44
Long-read assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function 0.04
An integrated germline and somatic genomic model for coronary artery disease 0.18
Mapping the heritability of disease: a nationwide study 0.03
A blueprint for local and distal invasion programs in glioblastoma 0.32
Extensive enhancer crosstalk controls activation during adipogenesis 0.14
EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles 0.37
Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy 0.53
iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostaining 0.08
Shared Genetic Liability across Systems of Psychiatric and Physical Illness 0.10
Genetic modifiers of -ε4-associated cognitive decline 0.02
FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling 0.04
KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans 0.02
A multi-ancestry genetic reference for the Quebec population 0.03
Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform 0.08
Cross-ancestry comparison of aptamer and antibody protein measures 0.16
The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations 0.86
TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis 0.07
Robust characterization and interpretation of rare pathogenic cell populations from spatial omics using GARDEN 0.10
Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants 0.13
Deep learning guided design of protease substrates 0.08
The Health for Life in Singapore (HELIOS) Study: delivering precision medicine research for Asian populations 0.01
Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain 0.53
Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations 0.04
Mapping rare protein-coding variants on multi-organ imaging traits 0.04
Widespread naturally variable human exons aid genetic interpretation 0.48
Complex genetic effects linked to plasma protein abundance in the UK Biobank 0.14
Cost-effective non-additive GWAS across 2329 diseases in 500,349 individuals 0.20
Generalizable morphological profiling of cells by interpretable unsupervised learning 0.11
Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths 0.75
Human plasma proteomic profile of clonal hematopoiesis 0.46
Recessive variants in the intergenic locus cause monogenic kidney disease responsive to anti-proteinuric treatment 0.54
Genetics and context for precision health in Greater Boston 0.80
scGALA advances graph link prediction-based cell alignment for comprehensive data integration and harmonization 0.05
Transcription start sites experience a high influx of heritable variants fueled by early development 0.20
3D spatial organization of heterogeneous + progenitors in the zebrafish heart field pre-patterns cardiovascular development 1.00
Explainable AI unravels sepsis heterogeneity via coagulation-inflammation profiles for prognosis and stratification 0.02
Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study 0.02
Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues 0.68
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations 0.10
Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions 0.20
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels 0.04
The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities 0.10
Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure 0.02
Improved allele frequencies in gnomAD through local ancestry inference 0.44
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations 0.01
Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis 0.01
Graph neural networks learn emergent tissue properties from spatial molecular profiles 0.03
Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma 0.34
Unveiling causal regulatory mechanisms through cell-state parallax 0.25
Modeling integration site data for safety assessment with MELISSA 0.40
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking 0.03
Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department 0.07
DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins 0.13
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells 0.04
PreMode predicts mode-of-action of missense variants by deep graph representation learning of protein sequence and structural context 0.20
Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development 0.10
Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC 0.16
Machine learning in Alzheimer’s disease genetics 0.00
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination 0.07
Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph embeddings 0.53
Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion 0.50
Distribution of copy number alterations and impact of chromosome arm call thresholds for meningioma 0.94
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses 0.08
Prevalent chromosome fusion in Vibrio cholerae O1 0.22
High-resolution detection of copy number alterations in single cells with HiScanner 0.65
Divergence in a eukaryotic transcription factor’s co-TF dependence involves multiple intrinsically disordered regions 0.08
Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions 0.06
A versatile information retrieval framework for evaluating profile strength and similarity 0.33
38 8.98
Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations 0.41
Patterns and drivers of 43,617 mosaic chromosomal alterations in blood 0.81
Empirically determined baseline masking strategies and other considerations for gene-level burden tests 0.47
Genetic association and machine learning improve the prediction of type 1 diabetes risk 0.15
De novo formation of -regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion 0.06
Genome-wide fine-mapping improves identification of causal variants 0.03
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity 0.01
Genomic, phenomic and geographic associations of leukocyte telomere length in the United States 0.56
A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders 0.07
Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk 0.26
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification 0.02
Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction 0.50
Impact and correction of segmentation errors in spatial transcriptomics 0.42
MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data 0.51
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion 0.21
Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk 0.48
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction 0.12
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation 0.02
A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction effects 0.08
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform 0.29
Scalable and accurate rare variant meta-analysis with Meta-SAIGE 0.06
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy 0.07
Complete genome assemblies of two mouse subspecies reveal structural diversity of telomeres and centromeres 0.11
Limited overlap between genetic effects on disease susceptibility and disease survival 0.14
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects 0.59
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes 0.01
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution 0.01
Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores 0.10
Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity 1.00
Noncoding rare variant associations with blood traits in 166,740 UK Biobank genomes 0.06
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution 0.00
A contextual genomic perspective on physical activity and its relationship to health, well being and illness 0.08
Improved multiancestry fine-mapping identifies -regulatory variants underlying molecular traits and disease risk 0.12
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy 0.07
Disruption of TAD hierarchy promotes LTR co-option in cancer 0.00
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations 0.00
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design 0.46
Linking regulatory variants to target genes by integrating single-cell multiome methods and genomic distance 0.60
1 0.01
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 0.01
1 0.06
A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice 0.06
7 1.32
An atlas of exposome–phenome associations in health and disease risk 0.67
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes 0.05
Clinical genetic variation across Hispanic populations in the Mexican Biobank 0.01
Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes 0.32
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities 0.17
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health 0.06
Polygenic prediction of body mass index and obesity through the life course and across ancestries 0.05
12 2.89
SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads 0.03
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny 0.02
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions 0.11
Pertpy: an end-to-end framework for perturbation analysis 0.03
Monod: model-based discovery and integration through fitting stochastic transcriptional dynamics to single-cell sequencing data 0.30
Nicheformer: a foundation model for single-cell and spatial omics 0.00
Improved reconstruction of single-cell developmental potential with CytoTRACE 2 0.07
PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories 0.06
scooby: modeling multimodal genomic profiles from DNA sequence at single-cell resolution 0.25
All-at-once RNA folding with 3D motif prediction framed by evolutionary information 1.00
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions 0.81
Morphological map of under- and overexpression of genes in human cells 0.21
1 0.02
Fine-mapping genomic loci refines bipolar disorder risk genes 0.02
5 1.19
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types 0.13
Dynamics of microcompartment formation at the mitosis-to-G1 transition 0.08
The mitotic STAG3–cohesin complex shapes male germline nucleome 0.02
DNA bendability regulates transcription factor binding to nucleosomes 0.89
GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion 0.07
1 0.09
Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta 0.09
3 0.25
Simplifying causal gene identification in GWAS loci 0.13
Genome-wide association study provides novel insight into the genetic architecture of severe obesity 0.02
Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction. 0.09
8 2.10
Orthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis 0.14
Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks 0.60
Mutations and structural variants arising during double-strand break repair 0.29
Uncovering heterogeneous intercommunity disease transmission from neutral allele frequency time series 0.13
Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping 0.02
Virulence hierarchies within the Mycobacterium tuberculosis complex 0.06
Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores 0.38
Participation bias in the estimation of heritability and genetic correlation 0.50
8 2.19
Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load 0.92
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis 0.05
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform 0.59
Multispecies pangenomes reveal a pervasive influence of population size on structural variation 0.40
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR 0.05
A human pan-disease blood atlas of the circulating proteome 0.01
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene 0.05
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism 0.13
4 0.92
Diverse database and machine learning model to narrow the generalization gap in RNA structure prediction 0.83
Dynamic human admixture histories over the past ~1300 years at the northern Himalayan frontier 0.02
Uncovering the regulatory landscape of early human B cell lymphopoiesis and its implications in the pathogenesis of B-ALL 0.04
Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules 0.03
1 0.02
DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis 0.02

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