Clinical Sciences articles for United Kingdom (UK)

Time frame: 1 June 2025 - 30 May 2026

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Count: 897

Article ‘Count’ for Clinical Sciences.

Journal Count Share
1 0.64
Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release 0.64
6 4.11
Topical hydrosulphide ion gels: A Paradigm shift in onychomycosis treatment 0.96
Hyaluronic Acid–Phosphatidylcholine Complexes as Reductionist Mimics of Extracellular Vesicle–Mediated Boundary Lubrication in Synovial Joints 0.20
Age and Region Dependent Biomechanical and Ultrastructural Differences in Porcine White Matter 1.00
A Physiological Oxygen Gradient Liver-Zonation-on-a-Chip Reveals HIF-2α Intervention in Hepatic Lipotoxicity 0.14
An image-based approach for advanced statistical quantification of architectural parameters and permeability in porous biological media 0.89
Development and mechanical characterisation of an animal model of acute compartment syndrome 0.92
2 0.91
LipoGels: Robust Self-Lubricating Physically Cross-Linked Alginate Hydrogels Embedded with Liposomes 0.80
Ferroelectric Heterojunction Membrane with Rapid Disinfection Through Coupling Piezoelectric and Pyroelectric Catalysis for Wound Regeneration 0.11
1 0.14
Push–Pull Electronic Effect and D‐Band Center Bi‐Modulated Bio‐Heterojunction Enzyme Enables All‐Stage Infected Wound Healing 0.14
4 2.38
Ingestion of diverse protein-rich whole-foods result in similar post exercise whole body and myofibrillar protein synthesis rates compared with a more isolated protein source in young adults 0.75
Post-malnutrition weight gain is associated with changes to muscle and energy metabolism in adolescence: a cohort analysis 0.89
STRENGTHS AND LIMITATIONS OF URINARY SUGAR TESTING; AN OBSERVATIONAL STUDY OF INTESTINAL PERMEABILITY AND ABSORPTION IN ADULTS AND CHILDREN IN ZAMBIA AND TANZANIA WITH REFERENCE TO MUCOSAL BIOPSIES 0.52
Associations of body mass index, waist circumference, and weight-adjusted waist index with body composition and biomarkers: A multinational pooled analysis 0.21
3 1.11
Newborn screening for type 1 diabetes using genome-based risk scores in the Early Check program 0.07
Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants 0.10
Availability of benign missense variant “truthsets” for validation of functional assays: Current status and a systematic approach 0.94
3 0.69
Artificial cycle frozen embryo transfer improves uterine perfusion during later pregnancy but is associated with higher preeclampsia incidence 0.17
PGT-A Mosaicism Reporting Lacks Clinical Predictive Value For Live Birth in a Multisite, Double-Blinded Study with Independent Validation 0.15
Increased Frequency of Autism by Previous Diagnosis and Screening in Children with Fetal-Neonatal Alloimmune Thrombocytopenia (FNAIT) with and without an Intracranial Hemorrhage (ICH) 0.38
4 0.83
Airway microbiome diversity, intra-mucosal bacteria, and spatial immunity in asthmatics and controls 0.68
Lower Airway Dysbiosis in NTM+ Bronchiectasis is Associated with NET-Predominant Severe Phenotypes 0.06
Electrical impedance tomography-guided PEEP and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial 0.05
The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis. 0.04
6 1.83
String-Powered Microfluidic Chip Integrating Heparin-Mediated One-Pot RT-RPA/CRISPR-Cas12a for Multiplex Detection of HFMD Viruses 0.09
Label-Free Visualization of the Antifungal Polyene Drug, Nystatin, in Biological Membranes Using Raman Microscopy 1.00
High-Throughput Quantification of Spike Protein Expression by LC–MS for mRNA-LNP Evaluation and Immune Response Profiling 0.06
An LC-Immuno-MRM-MS Winterplex Method Development Framework for Respiratory Viral Screening 0.08
Single-Molecule Analysis of Glycopeptide Antibiotic–Target Interactions Using Nanopore-Based Biomimetic Probes 0.17
Construction of Flexible Electrochemical Sensing Interfaces Based on Paper/PEDOT:PSS for the Detection of Cystatin C 0.43
4 1.26
Nitric Oxide to Reduce Acute Kidney Injury in Patients with Pre-existing Endothelial Dysfunction Requiring Prolonged Cardiopulmonary Bypass: A Randomized Clinical Trial. 0.05
Individualized Flow-Controlled versus Pressure-Controlled Ventilation in Cardiac Surgery: A Randomized Controlled Trial. 0.07
Minimal clinically important changes of patient-reported outcome measures for acute post-surgical pain. 0.14
Gabapentin for pain management following major surgery: a placebo controlled, double blind, randomized clinical trial (The GAP Study). 1.00
4 3.07
Slowing Down Water: Enhanced and Cation‐responsive MRI Contrast 1.00
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A 1.00
Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes 0.07
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity 1.00
4 1.20
Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis. 0.15
The Mediterranean Diet for Irritable Bowel Syndrome : A Randomized Clinical Trial. 1.00
Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial. 0.03
Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery. 0.02
7 1.87
Longitudinal Phenotypic Trajectories in GNAO1-Related Disorders: Defining Disease Progression and Clinical Profiles 0.04
High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis 0.40
Topographical Variation of Iron‐Rimmed Lesions in the Multiple Sclerosis Brain and Spinal Cord: A Neuropathological Study 0.73
Intranasal Seletracetam in a Patient with Reading Epilepsy: First‐in‐Human Use to Prevent Reflex Seizures 0.10
The Phenotypic Spectrum of Sporadic Creutzfeldt‐Jakob Disease Cortical Subtype 0.18
Identification of New scpKCNT1/scp‐Epilepsy Drugs by iIn Silico/i, Cell, and iDrosophila/i Modeling 0.40
The Spectrum of Neurologic Phenotypes Associated With scpiNUS1/i/scp Pathogenic Variants: A Comprehensive Case Series 0.03
4 0.21
Cancer in the Excluded Stomach After Gastric Bypass Surgery for Obesity. 0.07
Long-term Follow-up After Hypothermic Oxygenated Machine Perfusion in DCD Liver Transplantation 0.05
Defining Global Benchmarks for Robotic Liver Resections: An International Multicenter Study. 0.02
Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer: A European Multicenter Study Based on the GASTRODATA Registry. 0.06
29 9.97
Thresholds for efficacy outcomes in psoriatic arthritis vary according to baseline disease activity but not according to prior tumour necrosis factor inhibitor treatment 0.13
Whole blood transcriptome profiling in patients treated with deucravacitinib and novel mechanistic insights into TYK2 inhibition in lupus: results from a post hoc analysis of the PAISLEY SLE phase 2 trial 0.11
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study 0.12
Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis 0.03
Risk score for early mortality to stratify for intensive SSc therapy in the EUSTAR network: the RESIST score 0.05
Quantitative MRI tenosynovitis volume explains the association between tendon involvement and future development of clinical arthritis in anti-cyclic citrullinated peptide-positive at-risk individuals 0.94
Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials 0.02
How long do people with rheumatic and musculoskeletal diseases stay healthy and in work across Europe? Analysis of data from SHARE and ELSA 1.00
Progression from at-risk state to clinical and severe systemic lupus erythematosus involves molecular dysregulations potentially reversible by biologics: implications for early diagnosis and treatment 0.08
The epigenomic landscape of primary tissues in osteoarthritis 0.33
The positive perspective paradigm: proposal of a model to mitigate the impact of chronic inflammatory arthritis through comprehensive and early intervention 0.29
Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis 1.00
Type I interferon endotypes drive divergent clinical trajectories in childhood-onset SLE uncovered through a novel systems immunology approach 0.76
A brain-driven neural circuit contributes to tissue regeneration in joint cartilage 0.07
Untargeted breathomics identifies metabolic signatures of immune activity, intestinal integrity, and fatigue in systemic lupus erythematosus 0.14
Antimitochondrial antibodies in systemic lupus erythematosus are associated with and predict nephritis, arterial vascular events, and mortality 0.09
Effects of clofutriben, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, on the efficacy and toxicity of prednisolone in patients with polymyalgia rheumatica: a single-blind controlled trial with sequential cohorts 0.08
Tirzepatide and change in uric acid and its association with weight reduction: post hoc analyses of the SURMOUNT-1 randomised placebo-controlled trial 0.25
Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response 0.78
Healthy human enthesis stromal cells mediate immunoregulation via the CD39/CD73 adenosine ectonucleotidase pathway 1.00
Short-chain fatty acids and their gut microbial pathways distinguish rheumatoid arthritis in discordant monozygotic twins 0.12
Augmentation of immunothrombosis as a key mechanism underlying JAK inhibition associated hypercoagulability in rheumatoid arthritis 0.92
Inhibition of structural damage progression with the selective interleukin-23 inhibitor guselkumab in participants with active PsA: results through week 24 of the phase 3b, randomised, double-blind, placebo-controlled APEX study 0.08
Transcriptomic profiling of Sjögren’s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity 0.50
Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy 0.23
HLA loci heterozygosity modulates genetic risk in idiopathic inflammatory myopathies 0.66
A glossary of signs and symptoms of giant cell arteritis 0.10
Spatiotemporal distributions and regional disparities of rheumatoid arthritis in 953 global to local locations, 1980-2040, with deep learning-empowered forecasts and evaluation of interventional policies’ benefits 0.03
Exploring the limit of image resolution for human expert classification of vascular ultrasound images in giant cell arteritis and healthy subjects: the GCA-US-AI project 0.05
1 0.06
Cardiorespiratory fitness in individuals with spinal cord injury: the relationship with motor completeness 0.06
22 8.94
Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts 0.38
PEPITEM Regulates the Synovial Microenvironment During Immune-Mediated Inflammatory Arthritis to Limit Disease 0.83
Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study 0.20
The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Antineutrophil Cytoplasmic Antibody–Associated Vasculitis 1.00
Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial 0.13
Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept Study 0.08
Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort 0.04
Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results From the Phase 2 Randomized Trial 0.33
Unveiling Endotypes in Systemic Lupus Erythematosus Through Multiomic Analysis: Insights Into Cardiovascular and Renal Complications 0.19
Baseline Interleukin‐10 Levels as a Predictive Biomarker for Achieving Clinical Response With Abatacept in Patients Who Were Disease‐Modifying Antirheumatic Drug Naive and Anti–Citrullinated Protein Antibody Positive With Early Rheumatoid Arthritis 0.07
Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis 0.04
Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial 1.00
Risk factors for relapse in ANCA-associated vasculitis among patients with relapse after induction of remission with rituximab 0.20
Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand? 0.18
Incidence of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis Treated With scpJAK/scp Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs: Data From an International Collaboration of Registries 0.07
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients 0.05
Late‐Onset Spondylarthritis Presenting as Glucocorticoid‐Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where scpTNF/scp or scpIL/scp‐17 Blockade may have a Therapeutic Role 0.97
Effect of Long‐Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies 0.10
Paradoxical Activation of Entheseal Myeloid Cells by scpJAK1/scp and Tyk2 Inhibitors via Interleukin‐10 Antagonism 1.00
Comparative Effectiveness of Abatacept versus Adalimumab in Shared Epitope positive and negative Rheumatoid Arthritis patients 0.93
Clonal sharing of CD8+ T‐cells links skin and joint inflammation in psoriatic arthritis 1.00
A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis 0.13
1 0.53
Plasmodium knowlesi can adapt to infect Duffy-negative erythrocytes 0.53
12 5.55
Biosignatures of cognitive basic symptoms mark a distinct neurodevelopmental pathway to schizophrenia 0.09
Exploring the association between antidepressants, progression and mortality in Huntington’s disease 1.00
Biological classification of memory clinic patients 0.08
Distinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder 0.04
Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia 0.71
Biallelic variants in iCOX18/i cause a mitochondrial disorder primarily manifesting as peripheral neuropathy 0.28
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease 0.13
Treatment resistant recurrent unipolar and bipolar depression: associative learning abnormalities 0.60
Brain health concerns in former rugby players: clinical and cognitive phenotypes 1.00
Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial 0.04
Stimulation of the human ventral tegmental area increases strategic betting 0.58
Impaired reward sensitivity in Parkinson's depression is unresponsive to dopamine treatment 1.00
14 8.57
Nationwide outcomes of fenestrated endovascular aneurysm repair 1.00
Presacral tumours: international consensus on diagnosis and management 0.35
Diagnosis of inflammatory bowel disease following symptomatic faecal immunochemical testing – A population based cohort study 0.96
Preoperative low-energy diets for patients with body mass index amp;gt;30kg/m2 undergoing non-bariatric surgery: A pilot feasibility randomized clinical trial and a systematic review and meta-analysis of efficacy data 0.06
Day case and inpatient elective thyroid lobectomy across England: observational study of variation in practice and safety 1.00
Emergency hospital admissions while on an elective waiting list in England: an observational study using administrative data 1.00
Performance indicators for organ donation and transplantation programmes in Europe: modified Delphi consensus study 0.50
Parallel Endografting And Chimney Endovascular (PEACE) registry outcomes in emergency repair of complex abdominal aortic aneurysms 0.07
Outcomes after elective inguinal hernia repair with mesh performed by associate clinicians versus medical doctors in Sierra Leone: 5-year follow-up of a randomized clinical trial 0.05
Qualitative perspectives (on incoming medical teams during conflict) from surgeons in the Middle East and North Africa 0.92
Training needs analysis of surgical teams in Somaliland 0.60
Treatment strategies for Boerhaave syndrome: multinational retrospective cohort study 0.06
Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial 1.00
Comparison of outcomes after living and deceased donor kidney transplantation: UK national cohort study 1.00
9 4.79
A comparison of deep multiomics profiles across ethnicity, geography, and age 0.03
Phages communicate across species to shape microbial ecosystems 0.44
Arbitrium phages can manipulate each other’s lysis/lysogeny decisions 0.94
Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air 0.07
Genetic modifiers and ascertainment drive variable expressivity of complex disorders 0.03
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization 0.83
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites 0.53
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment 1.00
Dopamine encodes deep network teaching signals for individual learning trajectories 0.92
5 1.93
A fungal pathobiont promotes Streptococcus vaginal persistence and pathogenesis through physical and metabolic interactions 0.25
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health 0.90
A DNA recognition-mimicry switch governs induction in arbitrium phages 0.37
Molecular basis of 60 years of antigenic evolution of human influenza A(H3N2) virus neuraminidase 0.32
Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease 0.10
3 0.88
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism 0.03
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes 0.15
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication 0.70
1 1.00
Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up of a phase 2 clinical trial 1.00
2 1.82
Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer 1.00
β-Lactamase cleavable antimicrobial peptide–drug conjugates 0.82
4 1.18
Prophylactic Hemostatic Treatment to Control Iatrogenic Bleeding During Endobronchial Biopsy (PROTECT Study) 0.09
A National Evaluation of Intercostal Chest Drain Removal Strategies 1.00
Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients with Impaired Consciousness: A Multicenter Randomized Controlled Trial 0.02
Covert triage during the COVID-19 pandemic: A qualitative analysis of rationing in intensive care 0.07
2 0.97
Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: a Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial. 0.07
Impact of Cerebral Embolic Protection On Cognitive Function Following Transcatheter Aortic Valve Implantation: Data From the BHF PROTECT-TAVI Randomized Trial. 0.90
12 2.92
Patterns of HIV-1 Viral Load Suppression and Drug Resistance During the Dolutegravir Transition: A Population-based Longitudinal Study 0.33
Shorter Antitubercular Regimens Versus 9 Months of Isoniazid for Latent Tuberculosis in Children: A Systematic Review and Meta-Analysis 0.04
Risk of Major Adverse Cardiovascular Events With Dolutegravir Versus Efavirenz-Based Antiretroviral Therapy: Emulated Target Trials Using Routine, De-Identified Data From South Africa 0.21
Treatment adherence with an oral nine-month regimen for rifampicin-resistant tuberculosis in South Africa 0.23
Pregnant women with MDR/RR-TB and the all-oral 6-month regimen: experiences from a patient series in South Africa 0.06
Early symptom response in patients with uncomplicated urinary tract infection treated with gepotidacin or nitrofurantoin: pooled analysis from two pivotal Phase 3 studies 0.38
Reproducible Identification of Staphylococcus aureus Bacteremia Clinical Subphenotypes 0.31
Mortality Among Patients With Invasive Group A Streptococcal Infections Caused by the M1UK Lineage: A Retrospective Cohort Study in England and Wales 1.00
Prophylactic Efficacy of CD388, a Novel Drug–Fc Conjugate, in a Human Influenza A/H3N2 Virus Challenge Model: A Randomized, Controlled Phase 2a Study 0.23
Characterizing Treatment Adherence Trajectories in the endTB Multisite Cohort of Drug-Resistant Tuberculosis Patients: An Application of Group-Based Trajectory Modeling 0.02
Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum 0.06
Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study 0.06
10 1.92
Association Between Sex and Clinical Outcomes for Critically Ill Patients in India: A Registry-Embedded Cohort Study 0.25
The Influence of Older Age on RBC Transfusion Decisions in ICU Patients. 0.02
Sex-Specific Differences in Tidal Volumes and Mortality of Mechanically Ventilated Patients. 0.13
Location of In-Hospital Cardiac Arrest: An Updated Analysis of Epidemiology, Emergency Response, and Outcomes. 0.06
Identifying Research Priorities in Canadian Adult and Pediatric Critical Care: Results From a James Lind Alliance Priority Setting Partnership. 0.06
Platelet Transfusion Thresholds for Children Supported by Extracorporeal Membrane Oxygenation: The Extracorporeal Membrane Oxygenation Hemostatic Transfusions in Children (ECSTATIC) Feasibility Clinical Trial. 0.04
Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study. 0.02
Digital Twins to Evaluate the Risk of Ventilator-Induced Lung Injury During Airway Pressure Release Ventilation Compared With Pressure-Controlled Ventilation. 0.73
Persistent Critical Illness Among Intensive Care Patients in India: A Registry-Embedded Cohort Study. 0.56
Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy 0.03
5 1.87
Cocaine pollution alters the movement and space use of Atlantic salmon (Salmo salar) in a large natural lake 0.05
A common serial structure causes offline excitability changes linked to generalization between different memory types 0.67
Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army 0.07
Spatiotemporal dissociation of physical salience and stimulus evaluation in the human midbrain 1.00
Programmed seasonal brain shrinkage in the common shrew via water loss without cell death 0.09
6 3.97
Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo 1.00
BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes through controlling Reg3b mRNA decay 0.03
Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis 0.04
Single-cell transcriptomics identifies chondrocyte differentiation dynamics in vivo and in vitro 1.00
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila 1.00
NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation 0.90
7 0.68
Impact of Metabolic Bariatric Surgery on Weight Loss and Glycemic Control in Adults With Type 1 Diabetes: A Multicenter Retrospective Cohort Study. 0.02
Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the LookAHEAD Trial. 0.04
Interlaboratory Evaluation of Multiplex Autoantibody Assay Performance in the Islet Autoantibody Standardization Program 2024 Workshop. 0.14
Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial. 0.09
Dementia Risk in People With Type 1 Diabetes and Associated Risk Factors: A Nationwide, Register-Based Cohort Study. 0.10
A Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K. 0.04
Impaired Rest-Activity Rhythm Characteristics Predict Higher Risk of Incident Type 2 Diabetes in UK Biobank Participants. 0.25
1 0.11
The Effects of Prenatal GenX (HFPO-DA) Exposure on Gut Microbiota and Metabolic Function in Pregnant Rats and Their Offspring 0.11
3 0.54
Compact and cost-effective autofluorescence sensor for real-time environmental biofilm monitoring 0.17
Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study 0.14
Association between objectively assessed physical activity and kidney function among female agricultural workers in hot environments in Spain 0.24
2 0.90
Assessment of Population Relevance of Endocrine-sensitive Apical Endpoints in Fish Chronic Studies Using Individual-Based Models 0.40
The Impact of UVC Light on Indoor Air Chemistry: A Modeling Study 0.50
9 2.51
Optimal serum potassium concentrations in heart failure: an individual patient data meta-analysis 0.42
Cascade genetic screening in families with hereditary transthyretin amyloidosis: diagnostic and prognostic impact 0.01
Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases 0.08
C-reactive protein and cardiovascular risk in the general population 0.06
Frailty and long-term outcomes in younger patients with acute myocardial infarction 0.69
Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy 0.03
Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study 0.14
Transthyretin amyloid cardiomyopathy: natural history and treatment response assessed by cardiovascular magnetic resonance 0.93
Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool 0.15
3 2.20
RESECT: A Randomised Controlled Trial of Audit and Feedback in Non–muscle-invasive Bladder Cancer Surgery 0.95
Association of Polygenic Risk Scores for Depression, Anxiety, and Neuroticism with Lower Urinary Tract Symptoms Among Women 0.92
Duration of Androgen Suppression with Postoperative Radiotherapy (DADSPORT) for Nonmetastatic Prostate Cancer: A Collaborative Systematic Review and Meta-analysis of Aggregate Data 0.33
7 1.22
Recommendations for the Evaluation and Management of Inflammatory Bowel Disease With Irritable Bowel Syndrome–Like Symptoms: A Joint Rome Foundation and International Organization for the Study of IBD (IOIBD) Consensus 0.08
Achalasia and risk of esophageal squamous cell carcinoma and adenocarcinoma in a multinational study 0.06
Identification of a Druggable Target That Predicts Postoperative Crohn’s Disease Recurrence 0.04
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis 0.33
The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in Adults with Disorders of Gut-Brain Interaction: A Population-Based Study 0.60
Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation 0.07
Blood-based T Cell Diagnosis of Celiac Disease 0.05
12 5.07
Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes 0.06
Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study 0.92
<atl>Novel imyo/i -inositol to butyrate fermentation pathway in the prevalent human gut species iDysosmobacter welbionis,/i a bacterium associated with improved metabolic and liver health</atl> 0.11
Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility 0.12
Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis 0.83
Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection 1.00
Acute upper gastrointestinal bleeding in the UK: 2022 audit update 0.88
Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis 0.02
Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis 0.37
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies 0.03
Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea 0.67
Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease 0.08
8 0.96
Definition, diagnosis, and treatment of primary biliary cholangitis-autoimmune hepatitis (PBC-AIH) variant: An international expert Delphi consensus. 0.04
FIB-4 fails to identify significant liver fibrosis in people with HIV: A large multinational screening study. 0.05
Original research: Amplification of genetic and metabolic factors in alpha-1 antitrypsin deficiency. 0.09
Head-to-head comparison between vibration-controlled transient elastography and histology in predicting liver-related events due to metabolic dysfunction-associated steatotic liver disease. 0.08
Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity. 0.60
Predictors of fibrosis, clinical events and mortality in MASLD: Data from the Global-MASLD study. 0.01
Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study. 0.01
Association between longitudinal weight change and clinical outcome in individuals with MASLD. 0.10
2 0.77
A clinical protocol for the detection of comorbidities associated with monogenic causes of male infertility 0.07
Universal preimplantation genetic testing for monogenic disease (Karyomapping): diagnosis of amp;gt;1000 unique disorders with no detected misdiagnoses 0.70
1 0.13
Unsupervised Liver Deformation Correction Network Using Optimal Transport for Image-Guided Liver Surgery 0.13
4 0.15
Skin inflammation and itch response are independently regulated by distinct nociceptor subsets 0.04
Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques 0.06
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading 0.02
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation 0.03
1 0.80
Optimizing Intracellular Transport of Antimicrobial Metallohelices Delivers Selective Nanomolar Potency in E. coli 0.80
9 5.20
Estimates of vaccine effectiveness against measles and mumps: 14 years follow-up of a large cohort in Wales, UK 1.00
Exploring genetic confounding of the associations between screen time and depressive symptoms in adolescence and early adulthood 1.00
Reductions in malaria cases after deployment of dual-active ingredient insecticide-treated nets in Ghana—a Bayesian interrupted time series analysis 0.10
Reproducibility and associated regression dilution bias of accelerometer-derived physical activity and sleep in UK Biobank 1.00
Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health 0.33
Local progress towards achieving the End TB targets in Ethiopia: a geospatial analysis 0.33
Malaria amidst the COVID-19 pandemic in Gabon: an application of autoregressive integrated moving average (ARIMA) models within an interrupted time series (ITS) framework to hospital-based data 0.03
Adverse childhood experiences and lower urinary tract symptoms in adolescence: the mediating effect of inflammation 1.00
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage 0.40
4 1.03
Inversed impaired osteogenic activity in children with severe obesity due to deficiency compared to and deficiency 0.08
The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens 0.02
Sex-specific longitudinal associations between repeatedly measured movement behaviours and adiposity measures in school-aged children: a compositional data analysis approach 0.05
Metabolic bariatric surgery pays off: a longitudinal analysis of weight loss and HbA1c changes in real-world patients data in the West of Scotland 0.88
6 1.89
Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care 1.00
Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes 0.13
Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout 0.59
High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes 0.03
Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease 0.11
Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes 0.03
2 0.17
Risk and Protective Factors Associated With HIV-Related Mortality in Children Receiving Antiretroviral Therapy 0.08
40-Hz Light Stimulation and Emergence Delirium Incidence After Sevoflurane Anesthesia in Children 0.09
10 3.97
Antipsychotic Efficacy and Safety of LB-102 in the Treatment of Adults With Acute Schizophrenia 0.10
Methylphenidate Treatment and Risk of Psychotic Disorder 0.22
Psychological and Psychosocial Interventions for People With Schizophrenia and Co-Occurring Substance Use Disorders 0.04
Role of Serotonin in the Neurobiology of Schizophrenia and Association With Negative Symptoms 0.91
Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression 0.13
Progression of Transdiagnostic Stages From Childhood to Young Adulthood 0.09
Occurrence of Psychosis and Bipolar Disorder in Individuals With Attention-Deficit/Hyperactivity Disorder Treated With Stimulants 0.44
Incidence and Nature of Antidepressant Discontinuation Symptoms 0.95
Framework for Brain-Derived Dimensions of Psychopathology 0.22
Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans 0.89
1 0.07
Parathyroidectomy and Risk of Incident Diabetes in Patients With Primary Hyperparathyroidism 0.07
13 3.64
Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors: A Randomized Clinical Trial. 0.98
Teriparatide Plus Zoledronic Acid for Osteogenesis Imperfecta: A Randomized Clinical Trial. 0.88
Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough 0.13
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury 0.03
Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults 0.04
Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger 0.40
Intraoperative Driving Pressure–Guided High PEEP vs Standard Low PEEP for Postoperative Pulmonary Complications 0.03
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes 0.07
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock 0.00
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score 0.09
Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function 0.01
Lorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension 0.08
Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients 0.92
8 3.78
Atomistic scattering modeling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy 1.00
Prion propagation is controlled by discrete structural regions of PrP rather than overall stability 1.00
Mitochondrial movement in pancreatic alpha cells requires Miro2 and is regulated by glucose 0.60
Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy 0.08
Peroxynitrite detoxification by Trypanosoma cruzi heme peroxidase supports parasite survival in macrophages 0.29
Functional analysis of amino acid substitutions within human AGT1 in a cell-based platform to support the diagnosis of primary hyperoxaluria type 1 0.20
Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5 0.55
The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4 0.06
1 0.06
Impact of Stem Design on Periprosthetic Femoral Fracture Risk 0.06
21 9.93
Levothyroxine treatment response of cardiometabolic biomarkers in older adults with subclinical hypothyroidism 0.13
Real-world effectiveness of burosumab across age groups: X-linked hypophosphatemia (XLH) Disease Monitoring Program 0.08
Real-world impact of treatment on growth in children with X-linked hypophosphatemia 0.15
Clinical features of androgen abuse withdrawal in men during the first year of cessation: a community dwelling study 0.95
Cigarette smoking exposure and clinical outcomes in Graves' disease 1.00
Severity of MASH activity by iron-corrected MRI predicts insulin resistance and cardiometabolic risk in type 2 diabetes 0.08
Clinical spectrum of extreme insulin resistance syndromes treated with rhIGF-1: A single-center experience 0.80
High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study 0.28
<atl>Expanding the clinical tumor phenotype of the iEPAS1/i -asssociated tumor syndrome</atl> 0.73
Personalized Drug Screening and Risk Assessment in Patient-Derived Gastroenteropancreatic Neuroendocrine Neoplasms 0.05
Discordance Between Online Information and Male Hypogonadism Clinical Guidelines: A Global Multilingual Content Analysis 0.72
Population prevalence, penetrance, and mortality for genetically confirmed MODY 1.00
MECP2 Rare Variants in Boys With Central Precocious Puberty 0.15
TRIAC Therapy Relieves Hyperthyroid Symptoms, Lowering T4, T3, and Metabolic Rate in Resistance to Thyroid Hormone β 0.75
Higher circulating testosterone linked to higher CAD risk in men: Mendelian randomisation and survival analyses 1.00
Association of IGF-1 levels with height from childhood to adulthood: An observational and Mendelian randomization study 0.14
Trends In Reported Outcomes for Growth Hormone Therapy In Children With Growth Hormone Deficiency 0.20
Children with diabetes and at least one non-autoimmune feature should be considered for monogenic diabetes testing 0.26
Myofibrillar Protein Synthesis Rates Do not Differ With Low and High Estradiol Concentrations Across the Menstrual Cycle 0.75
Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study 0.05
Defining puberty and spectrum of hypogonadism in Alström Syndrome 0.66
6 0.64
Variation in antiviral immunity and inflammation pathways precedes HIV-1 infection in a high-risk African cohort 0.19
Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis 0.04
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes 0.05
Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome 0.22
Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models 0.09
Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models 0.04
2 0.43
Efficacy and Safety of Anselamimab in Immunoglobulin Light Chain Amyloidosis: Results From the Randomized CARES Trials 0.06
New Validated Staging System for Light Chain (AL) Amyloidosis With Stage IIIC Defining Ultra-Poor Risk: AL International Staging System. 0.38
3 1.83
CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β 0.84
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis 0.02
iPlasmodium falciparum/i infection induces T cell tolerance that is associated with decreased disease severity upon re-infection 0.97
13 3.26
Ammonia measurement in cirrhosis: International Delphi consensus recommendations from ISHEN 0.18
Genetic evidence that FGF21 signaling reduces problematic alcohol use and alcohol‐related liver disease 0.21
Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis 0.04
Use of intracranial pressure monitoring and risk factors for the development of intracranial hypertension in acute liver failure 1.00
Utilization of liver grafts obtained from donation after medical assistance in dying: A Canadian multicenter experience 0.04
Refining the Baveno VII criteria for clinically significant portal hypertension: an individual-patient data meta-analysis 0.05
Consensus position statements for the standardized application of histological grading and staging systems in MASH clinical trials 0.10
Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis 0.15
Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis 0.13
Effect of Hypertension on Long-term Adverse Clinical Outcomes and Liver Fibrosis Progression in MASLD 0.05
Identification and validation of RIPK3 as a novel biomarker to predict outcomes in patients with acutely decompensated cirrhosis 0.25
Patient-derived liver organoids recapitulate liver epithelial heterogeneity and enable precision modeling of alcohol-related liver disease 0.06
Dissecting metabolic dysfunction- and alcohol-associated liver disease (MetALD) using proteomic and metabolomic profiles 1.00
23 6.93
Schistosoma mansoni Infections Are Associated With Fecal Calprotectin Markers of Gut Inflammation After Accounting for HIV, Hepatitis B, and Malaria 0.38
Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity 0.93
<atl>Predicting risk of iPlasmodium vivax/i microscopy-detected episodes using serological markers in patients with iPlasmodium falciparum/i malaria: a multi-country diagnostic performance evaluation</atl> 0.08
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia 0.04
Specific Biomarkers Differentiate Cerebral Malaria From Other Causes of Coma in African Children 0.13
Unsuppressed viraemia and lower CD4 count associated with faster telomere attrition in African children with perinatal HIV on long-term antiretroviral therapy 0.53
Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity 0.88
The Effect of a 5-Day Course of Azithromycin on Streptococcus Pneumoniae Carriage and Antimicrobial Resistance Among Kenyan Children Discharged From Hospital 0.08
CSF Hypo-Inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis 0.09
Chronic malaria is associated with trauma-related splenic rupture requiring splenectomy 0.01
Defining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea 0.04
<atl>Safety and immunogenicity of a iKlebsiella pneumoniae/i tetravalent bioconjugate vaccine (Kleb4V) administered to healthy adults: A first time in human phase I/II randomised and controlled study</atl> 0.50
Relationship Between Group 3 Innate Lymphoid Cells and Th17 in Human Nasopharynx-Associated Lymphoid Tissue and the Association With Pneumococcal Carriage 0.91
Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom 0.90
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV 0.17
VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results 0.18
Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary iClostridioides difficile/i Isolates 0.08
Virological and Immunological Outcomes of Combined Therapeutic Interventions and Dendritic Cell Therapy in People With HIV 0.02
Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial 0.05
Brain imaging and whole blood targeted transcriptomic analyses to characterise cerebral infarctions in children with tuberculous meningitis 0.40
External validation of paediatric pneumonia and bronchiolitis risk scores to predict mortality in children hospitalised in Kenya: a retrospective cohort study 0.48
Plasma Proteomics Reveals Distinct Signatures in Occult and Microfilaremic Loa loa Infections 0.02
Bacterial and Viral Coinfections in Adult Patients Hospitalized With COVID-19 Throughout the Pandemic: A Multinational Cohort Study in the EuCARE Project 0.05
11 5.74
Acute Anxiety Selectively Enhances Value-Free Random Exploration through Frontoparietal Engagement 0.87
Distinct Response Selectivity Changes in the Primary Visual and Parietal Cortex during Visual Discrimination Learning 1.00
Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Non-Occurrence of Visual Signals in Perceptual Decision-Making 0.06
Punishments enhance reward learning by modulating striatal prediction errors 0.86
Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity 0.14
Reduced Pavlovian value updating alters decision-making in sign-trackers 0.10
Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats 1.00
DMT-induced shifts in criticality correlate with self-dissolution 0.38
Dopamine and temporal discounting: revisiting pharmacology and individual differences 0.13
Widely used CaMKII regulatory segment mutations cause tight actinin binding and dendritic spine enlargement in unstimulated neurons 1.00
Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1) 0.22
17 10.87
Glucose and fructose contributions to exogenous carbohydrate oxidation and performance at moderate altitude 0.86
Caloric restriction and aerobic exercise differentially counteract muscle–tendon dysfunction following diet‐induced obesity in C57BL/6J mice 0.20
Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers 0.81
Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG 1.00
Maximal exercise at high altitude does not exacerbate inflammation in the human brain 0.17
Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling 1.00
Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males 0.17
Role of reactive oxygen species in mediating peripheral hypoxic vasodilation and sympathoexcitation at high altitude 0.59
Utility of local capillary supply indices: Insights from computational image‐based modelling 0.43
Long‐term passive heat acclimation enhances maximal oxygen consumption via haematological and cardiac adaptation in endurance runners 1.00
Isolating the effects of carbohydrate and lipid availability on exercise‐induced skeletal muscle signalling in males 0.81
Exercise and hypoxia independently stimulate platelet liberation of brain‐derived neurotrophic factor and platelet factor 4 0.21
NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men 0.86
Visual modulation of vestibular‐evoked balance response disturbed by posterior cortical atrophy 1.00
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study 0.08
Effects of a combined energy restriction and vigorous‐intensity exercise intervention on the human gut microbiome: A randomised controlled trial 0.69
Post‐exercise hot water immersion enhances haemodynamic and vascular benefits of exercise without further improving cardiorespiratory fitness, glucose, lipids or inflammation 1.00
2 2.00
Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2) 1.00
Prospective evaluation and successful outcomes using vacuum bell therapy for pectus excavatum in selected pediatric patients: Analysis of a prospective cohort study of 240 patients 1.00
2 0.64
Adolescents’ Relationships With Their Parents and Peers as Mediators Between Economic Circumstances and Emotional Symptoms: A Multicountry Longitudinal Analysis 0.61
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis 0.03
6 0.35
Perioperative Management in Nail Surgery: An International Delphi Consensus Statement 0.08
Development of a Core Outcome Set for Clinical Trials in Melasma 0.05
Impact of early treatment of psoriasis on disease recurrence—Results from the STEPIn study 0.07
Bimekizumab demonstrated a favorable safety profile and high levels of efficacy with up to 2 years of treatment in patients with moderate to severe hidradenitis suppurativa: Pooled results from two phase 3 randomized, controlled trials and their open-label extension 0.09
Impact of Immunosuppression on Cutaneous Squamous Cell Carcinoma Outcomes 0.04
Establishment of standardized definitions and a core set of outcome characteristics following hidradenitis suppurativa surgery developed by an expert Delphi consensus 0.03
2 0.25
PGLa and Magainin 2 Can Porate Membranes via Transient Hourglass-Shaped Toroidal Pores 0.19
Macrocyclic Phage Display for Identification of Selective Protease Substrates 0.06
9 1.51
High-Dose vs Standard-Dose Influenza Vaccine in Chronic Kidney Disease The DANFLU-2 Trial Subgroup Analysis 0.03
Myocardial Amyloid Burden in Transthyretin Amyloidosis 0.70
PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery A Multicenter, Randomized Trial 0.07
Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis from ATTRibute-CM 0.09
Timing of Mortality Benefit in Outcomes Trials in Transthyretin Amyloidosis 0.29
Influence of Type 2 Diabetes on the Effects of Tirzepatide in Patients With Heart Failure and a Preserved Ejection Fraction With Obesity A Prespecified Stratification-Based Analysis 0.05
Adiposity-Related Anthropometrics and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction A Participant-Level Pooled Analysis of Randomized Clinical Trials 0.16
Effects of Vutrisiran on Cardiac Function and Outcomes in Patients With Transthyretin Amyloidosis With Cardiomyopathy 0.08
Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B 0.06
3 0.61
Association Between Herpes Zoster and Risk of Incident Fragility Fractures in scpUS/scp Veterans: A Matched Cohort Study 0.47
Physical Resilience After Hip Fracture: Unpacking the Roles of Resistance and Recovery 0.10
Communication Surrounding Treatment Preferences for Older Adults With Dementia During Emergency Medical Services Response 0.05
13 2.72
Efficacy and Safety of Atrasentan in Patients with IgA Nephropathy Receiving Sodium-Glucose Cotransporter 2 Inhibitors: Placebo-Controlled, Crossover Trial. 0.06
Systemic Phosphate Elevations Induce FGF23 Production in Skeletal Muscle to Reduce Renal Phosphate Reabsorption in Mice 0.07
Inhibition of Interleukin-33 in Diabetic Kidney Disease 0.25
Integrin Alpha1 Beta1 Promotes Interstitial Fibrosis and Cyst Growth in a Mouse Model of Polycystic Kidney Disease​ 0.67
Streamlining the Histopathological Workflow in Diabetic Kidney Disease with Artificial Intelligence. 0.08
Erythroid ACKR1 Deficiency Aggravates Immune-Mediated Kidney Disease. 0.23
Effect of Finerenone on Morbidity and Mortality in CKD. 0.13
Differential Cell-Specific, Regulatory Roles of FcγRIIB through IgG in IgA Nephropathy. 0.10
Effects of Dapagliflozin on Health-Related Quality of Life in Patients with CKD. 0.17
Genetic Variation and Ultrafiltration with Peritoneal Dialysis: A Genome-Wide Association Study. 0.12
Measurement, Estimation, and Correlates of the Glomerular Filtration Rate before and after Bariatric Surgery. 0.08
Predictive Value of the Oxford Classification for the Effect of Glucocorticoid Therapy in IgA Nephropathy. 0.09
Biomarkers of Kidney Failure and All-Cause Mortality in CKD. 0.68
2 0.25
Thyroid hormones and epithelial ovarian cancer risk and survival: results from the European Prospective Investigation into Cancer and Nutrition study 0.09
Trends in the incidence of cancers related to HIV-AIDS in Harare, Zimbabwe 1990-2019 0.17
9 1.31
A post hoc analysis of BLISS-LN found Belimumab plus mycophenolate mofetil improves kidney outcomes versus placebo plus mycophenolate mofetil in active lupus nephritis 0.22
Insights from the BLISS-LN Phase 3 study of biomarker associations with kidney response to belimumab in lupus nephritis 0.17
Reduced podocyte stiffness is a feature of proteinuric kidney disease 0.13
A population-based, regression discontinuity analysis examined the effects of nationwide alerting for acute kidney injury on health care and patient outcomes 0.43
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy 0.03
Genotype-phenotype characteristics and disease progression of FAN1-related karyomegalic tubulointerstitial nephropathy 0.05
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1) 0.10
Causal assessment of CKD-MBD biomarker alterations on CKD progression through a g-formula analysis in the EQUAL Study 0.13
Integrating estimated glomerular filtration rate and kidney replacement therapy criteria within the definition of kidney failure 0.07
1 0.05
Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation 0.05
20 7.36
How muscle talks to brain: apelin protein mediates exercise-induced antidepressant effects 0.06
Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study 0.12
Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis 0.04
A longitudinal DNA methylation atlas and its link to brain structure and mental health 0.11
Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders 0.80
Combining neurobiological markers and a sociodemographic risk score to predict adolescent depression – An IDEA RiSCo prospective cohort study 0.30
Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide 0.03
Delay discounting correlates with depression but does not predict relapse after antidepressant discontinuation 0.50
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression 0.03
Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium 0.05
Investigating the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences 0.93
Mapping the reciprocal interactions between antidepressants and the gut microbiome: novel targets for the personalisation and optimization of drug response 0.19
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group 0.05
Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort 0.88
Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders 0.38
Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes 0.05
GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study 0.85
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth 0.06
Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo 0.96
Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study 1.00
1 0.17
Inhaled Virus-Mimicking Particles Elicit Dose-Dependent Immune Response against SARS-CoV-2 with Sex-Bias ACE2 Activity in Mice 0.17
15 4.41
Sleep chart of biological ageing clocks in middle and late life 0.08
HIV-1 signalling remodels nuclear pores to licence infection 1.00
Evolution of pandemic cholera at its global source 0.29
Insulin resistance prediction from wearables and routine blood biomarkers 0.06
Integrase anchors viral RNA to the HIV-1 capsid interior 0.79
Prevalence of Alzheimer’s disease pathology in the community 0.05
Spatial fibroblast niches define Crohn’s fistulae 0.97
Maternal stress triggers early-life eczema through fetal mast cell programming 0.07
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury 0.01
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics 0.06
The spatiotemporal distribution of human pathogens in ancient Eurasia 0.13
Nutrients activate distinct patterns of small-intestinal enteric neurons 0.15
Feline infectious peritonitis epizootic caused by a recombinant coronavirus 0.66
Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice 0.05
Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin 0.06
166 65.52
COXFA4L2 upregulation preserves residual cytochrome c oxidase activity in COXFA4-related Leigh-like encephalopathy 0.40
Long-read deep sequencing reveals high rates of multilineage transmission and rapid viral population changes in acute HIV infection 0.01
cell atlas as a single-cell resource for understanding parasite population heterogeneity and differentiation 1.00
An integrative approach for studying immunological variation in an aging population – The Milieu Intérieur follow-up study 0.01
Genetic determinants of Staphylococcus aureus adhesion shape virulence trade-offs in bacteremia 0.12
Interpretable machine learning and signal processing for automated reading and quality control of lateral flow tests for schistosomiasis 0.25
Epidemiological, immunological and virulence characteristics of persistent Streptococcus pneumoniae vaccine serotypes following vaccine introduction 0.17
CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand 0.26
Tocilizumab versus sarilumab among adults hospitalised with COVID-19: target trial emulation across England and Scotland 0.87
Clinically-applicable prediction of hospital stay and patient similarity retrieval in paediatric cardiology using machine learning 0.97
Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice 0.63
Multi-focal ultrasound neuromodulation to the dorsal anterior cingulate cortex disrupts behavioural and neural pain processing 1.00
Quantification of disease-associated RNA tandem repeats by nanopore sensing 0.56
Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting 0.23
Human brain changes after first psilocybin use 0.75
Impaired glucose tolerance and mild diabetes induce β-cell dysfunction in mice 0.85
The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning 0.72
Acute sleep rebound following sleep restriction is associated with reduced mortality risk 0.13
Dorsal prefrontal cortex drives perseverative behavior in mice 1.00
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network 0.18
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Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity 0.11
Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids 0.03
A group 1 hemagglutinin stem vaccine elicits broad humoral responses against influenza in phase 1/2a study 0.05
Multiomics characterization of acute child illness and mortality in Africa and South Asia 0.17
An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy 0.29
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes 0.06
Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse 0.04
Subcellular reorganization upon phage infection reveals stepwise assembly of viral particles from membrane-associated precursors 0.04
Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still’s disease 0.11
Pathogenic variants in the cohesin loader subunit MAU2 underlie a distinct Cornelia de Lange Syndrome subtype 0.01
Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut 0.08
Post-pandemic changes in population immunity have reduced the likelihood of emergence of zoonotic coronaviruses 0.83
In-utero exposure to chikungunya and child morbimortality: a population-based study using linked routine data 0.29
Unpacking sources of transmission in HIV prevention trials with deep-sequence pathogen data 0.09
Noradrenaline causes a spread of association in the hippocampal cognitive map 0.68
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Epilepsy-associated variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination 0.16
Transcriptional regulation of the pneumococcal capsule can dictate serotype-specific infection 0.15
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Regional nonsense constraint offers biological and clinical insights into genetic disease 0.93
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GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection 1.00
Latent transition analysis for longitudinal studies of post-acute infection syndromes 0.01
Immune-mediated protection and enhancement of dengue drives patterns of infant cases in Brazil 0.22
Biomarker-integrated prognostic stagings for Alzheimer’s Disease 0.01
A digital platform with activity tracking for energy management support in long COVID: a randomised controlled trial 0.91
Safety and biologic activity of a bispecific T cell receptor targeting HIV Gag in males living with HIV: a first-in-human trial 0.64
Large-scale capsid-mediated mobilisation of bacterial genomic DNA in the gut microbiome 0.25
Oligoprotein type I interferon signatures, but not variants, increase risk of systemic lupus erythematosus in UK Biobank 0.97
Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques 0.88
Using the linear references from the pangenome to discover missing autism variants 0.08
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice 0.04
Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome 0.58
Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitonin 0.13
Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort 0.07
Impact of a single fecal microbiome transplantation in adult women with anorexia nervosa: an open-label feasibility pilot trial 0.04
Time-dependent deployment of medial prefrontal cortical representations in male mice 0.06
Dynamins maintain nuclear envelope homeostasis and genome stability 0.65
Individual and population-level risk factors for new HIV infections among adults in Eastern and Southern Africa 0.31
Acute exercise rewires the proteomic landscape of human immune cells 0.05
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Risk of major adverse cardiovascular events with aripiprazole versus olanzapine, quetiapine, and risperidone in severe mental illness: a target trial emulation 0.90
Mapping risks of health conditions in people with atopic eczema in English primary care and hospital data 1.00
Reaching elimination of onchocerciasis transmission with long-term vector control and ivermectin treatment in Togo 0.25
Cascades of effectiveness of next-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions 0.03
Development of a replication-defective mpox virus platform for fundamental and therapeutic research 0.07
Persistent pneumococcal colonisation in antiretroviral-treated HIV infection is associated with nasal inflammation 0.26
A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity 0.00
Impact and cost-effectiveness of the community-led AMETHIST intervention among female sex workers in Zimbabwe 0.54
Circadian rhythm profiles derived from accelerometer measures of the sleep-wake cycle in two cohort studies 0.11
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations 0.02
A corticospinal signature for interindividual pain sensitivity 0.11
Systematic identification of bacterial factors driving intracellular lifestyle in non-professional phagocytes 0.38
Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic 0.04
Rehydration rescues mice from lethal infection 1.00
The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviour 1.00
Decline in HIV prevalence among female sex workers in Zimbabwe between 2013 and 2023 0.53
Large-scale characterisation of the nasal microbiome redefines colonisation status 1.00
Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae 0.67
Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion 1.00
The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools 0.04
Methylene blue treatment of fatal cerebral malaria and identification of potential blood biomarkers 0.10
Harnessing registry data to identify socio-demographic and socio-economic gaps in HIV care in the Netherlands 0.06
Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1 0.13
Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis 0.50
A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome 0.56
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action 0.71
Post-learning replay of hippocampal-striatal activity is biased by reward-prediction signals 1.00
A systematic review and meta-analysis of the impact of vaccination on prevention of long COVID 0.61
High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures 0.03
Climate variation and serotype competition drive dengue outbreak dynamics in Singapore 0.40
Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial 0.02
Adaptive stretching of representations across brain regions and deep learning model layers 0.25
HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial 0.09
Implantable bioelectronics for gut electrophysiology 0.65
Clinical and genomic features of Lynch syndrome differ by tumor site and disease spectrum 0.06
Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb 0.16
Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity 0.22
Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome 0.01
Probabilistic classification of late treatment failure in uncomplicated falciparum malaria 0.40
Physical activity levels may impact on the risk of premature mortality in people with epilepsy 0.03
transmission in China during the COVID-19 pandemic period (2020–2021) compared with the pre-pandemic period (2017–2019) 0.08
In situ gut microbiota editing: enhancing therapeutic efficacy for bacterial colitis by compatible oral hydrogel microspheres with phages 0.07
The pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response 1.00
Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry 0.70
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function 0.72
Complex de novo structural variants are an underestimated cause of rare disorders 1.00
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database 0.08
Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy 0.02
Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus 0.15
A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae 1.00
Bacterial warfare is associated with virulence and antimicrobial resistance 1.00
Neurocomputational basis of learning when choices simultaneously affect both oneself and others 0.29
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis 0.08
Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis 0.40
Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system 0.58
Low circulating miR-190a-5p predicts progression of chronic kidney disease 1.00
Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance 0.75
Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors 0.58
Within-host genetic diversity of pneumococcal serotype 3 during one-year prolonged carriage in a healthy adult 0.49
Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer 0.17
Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites 0.11
Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia 0.34
Rising dengue risk with increasing El Niño–Southern Oscillation amplitude and teleconnections 0.23
Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic 0.61
Transmission dynamics of sequence type 131 in households—a one health prospective cohort study 0.05
Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection 1.00
GPS Pipeline: portable, scalable genomic pipeline for Streptococcus pneumoniae surveillance from Global Pneumococcal Sequencing Project 0.60
Caudate serotonin signaling during social exchange distinguishes essential tremor and Parkinson’s disease patients 0.02
Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging 0.63
Trait anxiety is associated with reduced reward-related replay at rest 0.15
Neural correlates of human fear conditioning and sources of variability in 2199 individuals 0.03
Modelling transmission of Middle East respiratory syndrome coronavirus in camel populations and the potential impact of animal vaccination 0.83
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants 0.45
Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious 0.06
DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge 0.10
Early noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease 0.01
Seedless: on-the-fly pulse calculation for NMR experiments 0.94
Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP 0.79
Perinatal outcomes of symptomatic chikungunya, dengue and Zika infection during pregnancy in Brazil: a registry-based cohort study 0.40
Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis 0.20
Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence 0.04
A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images 0.02
Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics 0.36
Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes 0.55
Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers 0.04
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation 1.00
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge 0.02
A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay 0.71
Genetic risk-dependent brain markers of resilience to childhood Trauma 0.13
The impact of elective surgical hubs on elective surgery in acute hospital trusts in England 1.00
Variants in cause a novel oculo vertebral renal syndrome 0.22
Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial 0.06
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis 0.73
Ethnic disparities in COVID-19 mortality and cardiovascular disease in England and Wales between 2020-2022 0.97
Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa 0.31
Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight 0.59
Characterizing trachoma elimination using serology 0.12
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease 0.01
Structural basis of topoisomerase targeting by delafloxacin 1.00
The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial 0.01
Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants 0.02
Obesity drives depot-specific vascular remodeling in male white adipose tissue 0.13
Abstract rule learning promotes cognitive flexibility in complex environments across species 0.10
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling 0.96
2 0.56
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling 0.10
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling 0.46
3 1.93
Brain activity, disruption and connectivity comparisons identify origins of human metacognition in other primates 0.92
Individual versus group-based interventions: a systematic review and meta-analysis of physical activity, functional, psychosocial and health outcomes 0.14
Hybrid neural–cognitive models reveal how memory shapes human reward learning 0.88
4 0.17
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control 0.02
Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses 0.01
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis 0.08
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints 0.05
26 9.03
Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial 0.94
Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma 0.98
An international mega-analysis of psychedelic drug effects on brain circuit function 0.15
Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial 0.13
Deleterious coding variation associated with autism is shared across ancestries 0.00
Transmission dynamics of Oropouche virus in Latin America and the Caribbean 0.14
Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo 0.09
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 0.25
A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial 0.89
Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents 0.19
External trigeminal nerve stimulation in youth with ADHD: a randomized, sham-controlled, phase 2b trial 0.89
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study 0.03
Single-cell atlas of the developing Down syndrome brain cortex 0.34
Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial 0.17
Estimating the number of incorrect tuberculosis diagnoses in low- and middle-income countries 0.25
Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial 0.23
Cabotegravir and rilpivirine for treatment of HIV infection in Africa: week 96 results from the phase 3b randomized, open-label, noninferiority CARES trial 0.10
Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial 0.20
Varicella-zoster virus reactivation and the risk of dementia 0.08
A consensus blood transcriptomic framework for sepsis 0.50
Prevention of type 2 diabetes through prediabetes remission without weight loss 0.01
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions 0.97
Early-life serological profiles and the development of natural protective humoral immunity to in a high-burden setting 0.18
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial 0.08
Efficacy, public health impact and optimal use of the Takeda dengue vaccine 1.00
An international Delphi consensus for reporting of setting in psychedelic clinical trials 0.24
3 0.34
A neural signature of adaptive mentalization 0.13
Charting brain morphology in international healthy and neurological populations 0.01
A common computational and neural anomaly across mouse models of autism 0.21
3 1.24
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy 1.00
Structure and activation mechanism of a Lamassu phage and plasmid defense system 0.18
A nanobody-based therapeutic targeting Nipah virus limits viral escape 0.06
6 2.20
Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network activity 1.00
Molecular mechanisms mediating engram ensemble retrievability state in mice 0.06
Distinct representations of economic variables across regions and projections of the frontal cortex 1.00
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health 0.01
Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples 0.10
Competitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamics 0.03
9 5.35
Environmental uncertainty shapes human effort learning 0.93
Ultrasound neuromodulation reveals distinct roles of the dorsal anterior cingulate cortex and anterior insula in learning 0.75
Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes 0.13
Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions 0.01
The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice 1.00
Temperate phage evolve to integrate host stress and quorum signals in lysis–lysogeny decisions 0.67
Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems 0.20
Transient frontopolar cortex stimulation induces prolonged disruption to counterfactual processing 1.00
Attractive serial dependence arises during decision-making 0.67
4 3.08
Yap1 regulates motility and vertebral development and prevents kyphoscoliosis in zebrafish 1.00
A machine learning classifier to identify and prioritise genes associated with murine cardiac development 0.75
Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase 0.33
Genetic inference of on-target and off-target side-effects of antipsychotic medications 1.00
21 8.57
Characterization of the VHH-Fc construct rimteravimab in healthy adults and patients hospitalized for mild-to-moderate COVID-19: Two Phase 1 randomized clinical trials 0.10
Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data 0.24
Trends in HIV self-testing uptake in Africa: A modeling study of population-based surveys and HIV testing program data 0.09
Cost-effectiveness of esketamine versus alternative treatment strategies for treatment-resistant depression in Hong Kong: A multi-armed modeling study 0.13
The benefits of investments to combat HIV, tuberculosis, and malaria for primary healthcare from 2000 to 2023: An economic modeling analysis 0.43
Trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis: A modelling study 0.92
Urban and rural prevalence of tuberculosis in low- and middle-income countries: A systematic review and meta-analysis 0.33
Evaluating the biomedical and behavioral drivers of HIV incidence decline in adolescent girls and young women in Uganda: A mathematical modeling study 0.16
The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study 1.00
Associations of Creatinine Muscle Index with markers of sarcopenia and mortality in chronic kidney disease: A prospective cohort study 0.88
Estimating the global burden of viable Mycobacterium tuberculosis infection: A mathematical modelling study 0.69
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage 0.18
The association between implant design, age, sex and the rate of major reoperation in patients undergoing primary total hip replacement: A retrospective study of UK National Joint Registry and Hospital Episodes Statistics data 1.00
Impact of first-trimester ultrasound on early detection of major fetal anomalies: Nationwide population-based study of over 1 million pregnancies 1.00
The association of body mass index with patient outcomes after shoulder replacement surgery: Population-based cohort study using linked national data from the United Kingdom and Denmark 0.60
Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis 0.05
Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study 0.02
Machine learning algorithms and their predictive accuracy for suicide and self-harm: Systematic review and meta-analysis 0.22
Identifying care gaps along the HIV treatment failure cascade: A multistate analysis of viral load monitoring, re-suppression, and regimen switches in Zambia 0.23
Effect of pre-exposure prophylaxis on risky sexual behaviour of female sex workers in Dakar, Senegal: A randomised controlled trial 0.13
The transmission blocking activity of artemisinin-combination, non-artemisinin, and 8-aminoquinoline antimalarial therapies: A pooled analysis of individual participant data 0.16
26 9.43
Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus 0.22
Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84 0.09
Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations 0.09
SFTSV NSs protein is a tick antiviral RNAi response suppressor 0.87
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation 0.02
Antiretroviral therapy blocks natural selection on protective and disease-susceptible HLA-B alleles in HIV-1 infection 0.18
Podocin oligomers regulate the ordering of nephrin chains, providing the molecular basis of NPHS2 interallelic interactions 0.12
Catabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response 0.74
Reprogrammed SimCells for antimicrobial therapy 0.50
Understanding human metacontrol and its pathologies using deep neural networks 1.00
Probabilistic mapping and automated segmentation of human brainstem white matter bundles 0.10
T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B 0.11
Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature, and cytoarchitecture 0.03
Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes 0.01
Dynamic functional connectivity following cochlear implantation: Predicting speech outcomes and exploring brain network dynamics 0.17
The olfactory bulb endocast as a proxy for mammalian olfaction 0.16
Genetics of prelingual isolated deafness and Usher syndrome in the Maghreb and Jordan: Harnessing the potential of homozygosity 0.02
Mysterious illnesses have supernatural and ritualistic cures: Evidence from 3,655 century-old Irish folk cures 1.00
Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon 1.00
Habenula–ventral tegmental area functional coupling and risk aversion in humans 0.31
Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation 0.23
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition 0.13
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance 0.90
Ultradian rhythms of CRHPVN neuron activity, behavior, and stress hormone secretion 0.05
Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAΦ 0.50
Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan 0.92
4 1.33
Integrating microclimate to understand vector development and disease patterns: challenges and lessons from plague in Madagascar’s Central Highlands 0.54
Mourning ritual participation, subjective well-being and prosocial behaviour among the Luhya people of Kenya 0.29
Localized Rift Valley fever virus persistence explains epidemic and interepidemic dynamics and guides control strategies. 0.31
Postural stability and optic flow sensitivity following sight restoration from congenital bilateral cataracts. 0.20
7 1.19
Independent Testing of Published CT Models for PD-L1 Status in Non–Small Cell Lung Cancer 1.00
Spatiotemporal Development and Clinical Correlates of MRI-based Brain Myelination in Term- and Preterm-born Children. 0.03
Prevalence and Incidence of Paramagnetic Rim Lesions in Multiple Sclerosis: A Systematic Review and Meta-Analysis. 0.02
Risk Stratification of Sudden Cardiac Death in Nonischemic Dilated Cardiomyopathy: Arrhythmogenic Substrate Assessment in Cardiac MRI. 0.06
Comparison of a Specialized Large Language Model with GPT-4o for CT and MRI Radiology Report Summarization. 0.05
Impact of LI-RADS CT and MRI Ancillary Features on Diagnostic Performance: An Individual Participant Data Meta-Analysis. 0.02
Diagnostic Performance of CT/MRI LI-RADS Version 2018 Major Feature Combinations: Individual Participant Data Meta-Analysis. 0.02
8 2.83
A Hormone Cell Atlas maps the human endocrine system at cellular resolution 0.94
Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design 0.05
Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito 0.08
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus 0.04
Ancient origin of an urban underground mosquito 0.43
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations 0.93
1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk 0.14
Mitochondria protect against an intracellular pathogen by restricting access to folate 0.20
15 5.74
Serine protease HtrA promotes Campylobacter jejuni intestinal colonization through degrading antimicrobial peptide LL-37 0.11
Beyond formic acid: Peptides in carpenter ant venoms aid in disease protection 0.05
Multimodal platform for ITN efficacy: Surface chemistry, bioavailability, and mosquito behavior 0.83
SRC-mediated phosphorylation of UBC9 regulates inflammatory and metabolic signaling in alcohol-associated liver disease 0.07
The human amygdala in threat learning and extinction 0.11
Dengue infection elicits skin tissue-resident and circulating CD8+ T cells associated with protection from hospitalization 0.15
Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages 0.87
Bacteriophages mobilize bacterial defense systems via lateral transduction 0.52
Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA 0.27
Mechanistic insights into 50S precursor recognition and targeting by erythromycin resistance methyltransferase 0.09
Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing 0.67
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail 0.70
Exploring nationwide patterns of sleep problems from late adolescence to adulthood using machine learning 0.10
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress 1.00
NRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway 0.20
10 2.55
Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction 0.02
The E205D mutation in CYP6P3 drives pyrethroid insecticide resistance in the African malaria mosquito vector Anopheles gambiae 0.29
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis 0.02
Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses 0.18
A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis 0.86
Sprayable extracellular matrix hydrogel reduces postoperative adhesion formation and protects healing tissues in preclinical models 0.11
Synchronized dynamics of dengue across the Americas 0.01
Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis 0.20
Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease 0.81
A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint 0.05
11 4.62
Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis 0.09
Home based, tailored intervention to reduce rate of falls after stroke (FAST): randomised trial 0.08
Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study 1.00
Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials 0.90
Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis 0.44
Benefits and harms of ADHD interventions: umbrella review and platform for shared decision making 0.29
Patterns of war related trauma in Gaza during armed conflict: survey study of international healthcare workers 0.71
Trends in the shortfall of English NHS general practice doctors: repeat cross sectional study 0.94
Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial 0.02
Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis 0.03
ADHD drug treatment and risk of suicidal behaviours, substance misuse, accidental injuries, transport accidents, and criminality: emulation of target trials 0.12
2 0.76
RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis. 0.43
Structural basis of Fanconi anemia pathway activation by FANCM. 0.33
3 2.03
Short-term antagonism between bacteriophages and macrophages decreases with bacteria-phage coevolution 1.00
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug resistance plasmids 0.92
Ecological strategies of bacteria shape inherent phage diversity in Atlantic salmon gut microbiomes 0.11
2 0.59
Bimekizumab long-term response in psoriasis: Mechanistic insights into efficacy level and durability 0.53
Epinephrine and Emergency Medical Services Activation Recommendations During Acute Allergic Reactions in Community Settings: International Consensus Report 0.06
2 0.50
Lipocentric Non-Pore-Forming Membrane Depolarization Underlies the Antibacterial Activity of Ribosomal Protein S30 0.20
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core 0.30
14 4.97
Prevalence of liver fibrosis in the general population (the LiverScreen project): a multinational European cohort study 0.09
Efficacy and safety of LEVI-04 in patients with osteoarthritis of the knee: a randomised, double-blind, placebo-controlled, phase 2 trial 0.60
Survival outcome of VATS compared with open lobectomy for lung cancer: an individual patient data meta-analysis of randomised trials 0.44
Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial 0.07
Survivorship of modern total hip replacement to 30 years: systematic review, meta-analysis, and extrapolation of global joint registry data 0.15
Comparative efficacy and tolerability of antidopaminergic and muscarinic antipsychotics for acute schizophrenia: a network meta-analysis of randomised controlled trials indexed in international English and Chinese databases 0.01
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial 0.05
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on oral antiretroviral therapy: 48-week results of a phase 3, multicentre, randomised, open-label, non-inferiority trial 0.05
Surgical fixation versus non-surgical care for children with a displaced medial epicondyle fracture of the elbow (the SCIENCE study): a multicentre, randomised controlled, superiority trial and economic evaluation 0.93
A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial 0.14
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial 0.08
The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial 0.96
Safety and efficacy of steroidal mineralocorticoid receptor antagonists in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of randomised controlled trials 0.39
Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation 1.00
6 0.92
Safety, tolerability, pharmacokinetics, and efficacy of burosumab in infants with X-linked hypophosphataemia: an open-label, multicentre, non-randomised study 0.43
Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study 0.03
11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050 0.06
Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study 0.07
Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis 0.09
Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis 0.25
11 2.51
Effects of a peer-support lifestyle intervention on diabetes incidence in India (K-DPP): 9-year follow-up of a cluster-randomised, controlled trial 0.04
Uncomplicated malaria as a risk factor for COVID-19 duration and severity in western Kenya and Burkina Faso (MALCOV): a prospective cohort study 0.32
Association of linezolid interruption and rechallenge with clinical outcomes in patients with rifampicin-resistant tuberculosis in South Africa, 2018–22: an observational cohort study 0.03
Prevalence and outcomes of intrinsic capacity impairments assessed using the WHO Integrated Care for Older People (ICOPE) framework in The Gambia, South Africa, and Zimbabwe: a cross-sectional study 0.46
Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia 0.05
HIV testing during systematic screening for tuberculosis among household contacts in high-tuberculosis burden settings: a systematic review and meta-analysis 0.39
The effect of long-acting cabotegravir and rilpivirine treatment on drug resistance in South Africa: a modelling study 0.03
Causes, associated exposures, and outcomes of cirrhosis and hepatocellular carcinoma in Malawi: an observational cohort and case–control study 0.35
Global variation in patient factors, interventions, and postoperative outcomes for those undergoing trauma laparotomy: an international, prospective, observational cohort study 0.47
Evidence-based decision making for malaria elimination applying the Freedom From Infection statistical framework in five malaria eliminating countries: an observational study 0.31
Clinical impact and cost-effectiveness of the WHO-recommended advanced HIV disease package of care 0.05
2 0.15
Safety and efficacy of intensive task-specific training in people with recent spinal cord injury: a phase 3, pragmatic, randomised, assessor-blinded, superiority trial 0.08
Safety and effectiveness of the Walk ‘n Watch structured, progressive exercise protocol delivered by physical therapists for inpatient stroke rehabilitation in Canada: a phase 3, multisite, pragmatic, stepped-wedge, cluster-randomised controlled trial 0.07
2 1.97
Estimated effect of correcting inequalities in minimally invasive surgical resection in patients with colon cancer in England: a population-based study 1.00
Equity in cancer genomics in the UK: a cross-sectional analysis of a national cancer cohort 0.97
10 4.74
Clozapine rechallenge after neutropenia: a retrospective cohort study in the UK 0.90
First-episode psychosis and substance use involvement across birth cohorts in Canada: a retrospective longitudinal population-based study 0.08
Brief individual psychological intervention for people with probable personality disorder: a multicentre, researcher-masked, randomised, controlled superiority trial in England 1.00
Life event trajectories and suicidal ideation throughout adolescence: a prospective cohort study from Germany, France, Ireland, and the UK 0.39
Specific midlife depressive symptoms and long-term dementia risk: a 23-year UK prospective cohort study 0.78
Joint detection of risk for psychotic disorders or bipolar disorders in clinical practice in the UK: development and validation of a clinical prediction model 0.58
Disease relapse, all-cause mortality, and adverse events associated with long-acting injectable antipsychotics versus oral antipsychotics in older people with schizophrenia in Hong Kong: a population-based within-subject analysis 0.07
Antipsychotic prescriptions in people with dementia in primary care: a cohort study investigating adherence of dose and duration to UK clinical guidelines 0.89
Clozapine use and risk of infections in patients with schizophrenia in Hong Kong: a population-based cohort study 0.01
Absolute and relative risks of mental disorders in families: a Danish register-based study 0.04
24 5.97
Intravascular Ultrasound–Guided or Angiography-Guided Complex High-Risk PCI 0.13
IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease 0.27
Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism 0.03
Transdermal Estradiol Patches in Locally Advanced Prostate Cancer 0.98
Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial 0.92
Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus 0.04
Finerenone in Type 1 Diabetes and Chronic Kidney Disease 0.11
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes 0.07
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial 0.14
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy 0.05
Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents 0.06
Safety and Immunogenicity of an rVSV Lassa Fever Vaccine Candidate 0.22
Selective Decontamination of the Digestive Tract during Ventilation in the ICU 0.13
Common Diseases in Clinical Cohorts — Not Always What They Seem 0.13
Belzutifan for Advanced Pheochromocytoma or Paraganglioma 0.04
Nexiguran Ziclumeran Gene Editing in Hereditary ATTR with Polyneuropathy 0.10
High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults 0.03
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension 0.08
Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease 0.97
Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease 0.98
Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes 0.10
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity 0.18
Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis 0.20
Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma 0.02
2 1.96
Tool in lesion verification of shape-sensing robotic-assisted bronchoscopy with cone beam CT in sampling peripheral pulmonary nodules 1.00
Vibrotactile positional therapy for the treatment of positional obstructive sleep apnoea: a multicentre, randomised controlled trial 0.96
3 0.36
Wastewater surveillance of dengue and chikungunya during the worst arbovirus epidemic in Brazil 0.13
Worker exposure to bioaerosols from sludge dewatering facilities: risks and mitigations 0.15
Estimating the consumption of prescription opioids through wastewater analysis: The patterns of use in Italy 0.08

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