Clinical Sciences articles for Chinese Academy of Sciences (CAS), China

Time frame: 1 June 2025 - 30 May 2026

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Count: 271

Article ‘Count’ for Clinical Sciences.

Journal Count Share
12 2.90
A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy 0.29
A Sonopiezoelectric Z-Scheme Nanoplatform Synergizing Trace Ag+ for Eradicating Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia 0.08
Membrane-Targeting Poly(Amino Acids) with a Phage-Like Action Process for Antifungal Therapy 0.38
Metal–Organic Framework-Integrated Nanoplatform Orchestrates Osteochondral-Synovial Homeostasis for Osteoarthritis Therapy 0.02
Conformational versus Configurational Entropy: Deciphering the Alkyl Chain-Dependent Membrane Attack Mechanism of Ionic Liquid Derivatives 0.30
Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response 0.06
Lysosome-Targeting Nanochimeras Attenuating Liver Fibrosis by Interconnected Transforming Growth Factor-β Reduction and Activin Receptor-Like Kinase 5 Degradation 0.17
An Intein-Spliced Nipah G Protein Ferritin Nanoparticle Vaccine Provides Complete Protection against Lethal Nipah Virus Challenge 0.42
Defect-Boosted Piezoelectric and Nanozymatic Synergetic Catalysis for Deep Bacterial Abscess Therapy 0.50
Biosynthesis of Melanin with Engineered Probiotics for Oral Treatment of Ulcerative Colitis 0.22
Monitoring Abundance and Activity of Electrochemically Inactive Protein in a Single Cell by an Atomically Precise Metal Cluster-Based Electrochemical Sensor 0.18
Epitope-Optimized Influenza Hemagglutinin Nanoparticle Vaccine Provides Broad Cross-Reactive Immunity against H9N2 Influenza Virus 0.29
2 0.31
Biofilm penetrating and disrupting polymers to effectively treat endotracheal-tube-associated biofilm infections 0.25
Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance 0.06
11 3.68
Iron Sequestration by Magnesium Prussian Blue to Ameliorate Osteoarthritis Through Restoration of HIF-1α Signaling and Ferroptosis Inhibition 0.07
A Sonosensitizer-Cationic Polypeptide Conjugate Potentiates Sonodynamic Therapy for Mature Biofilm Eradication and Periodontitis Treatment 0.30
Zwitterionic Polymer-Functionalized Carbon Quantum Dots as High-Performance Nanolubricants for Potential Osteoarthritis Treatment 0.70
Kidney-Targeted Nanoparticles with ROS Scavenging and STING Inhibition for the Treatment of Acute Kidney Injury 0.09
Biochemically Responsive Bacterial Codes Enabled by Photodynamic AIE Nanoparticles for Advanced Information Encryption 0.03
Mechanically Robust Super-Lubrication Polycarbonate-Polyurethane (PCU) Enabled by Design of Dynamic Mechanics Network and Manufacture of Constrained Hydrogel Coating 0.67
An AB-Type Hydrogel CT Contrast Agent for Precise Localization of Intra-Abdominal Hemorrhage 0.63
Robust Superlubricity in Artificial Cartilage Hydrogels via Gradient Stress Dissipation and Comb-Like Polymer Structures 0.58
Flexible Wireless Electrical Stimulator Based on Liquid Metal High‐Density Coils for Chronic Pain Therapy 0.44
Highly Efficient Photocatalytic Elimination of Bacteria and Antibiotic Resistance Genes via a Strong Oxidation Surface in Donor-Acceptor SA-PDI@C60 0.13
Oxygen‐Immunomodulated Nanocatalysts Enhance Anti‐Infection by Trained Immunity 0.04
10 3.73
Antioxidant Proline Carbon Dot-Composited Poly(L-methionine) Hydrogel Restores Mitophagy to Alleviate Cellular Senescence in Intervertebral Disc Degeneration 0.42
Selective Induction of Cancer Cell Pyroptosis by Erbium Nanotuner Enhances Potent Anti‐Cancer Immunity 0.33
Sheath‐Inspired Durable Semi‐Convertible Hydrogel Enabled Controllable Lubrication and Contractibility 0.04
Selectively Breaking Bicontinuous Microphase Confinement for Sustainable and Unprecedented Superlubricating Hydrogels 0.83
Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment 0.35
Flexible Photovoltaic Neurostimulator for Analgesia 0.25
Oral Covalent Organic Frameworks as Dysbiosis‐Mitigating Oxalate Sequestrants for Crystalline Nephropathy 0.08
3D Acoustic Imaging Hitting the Diffraction Limit via Fully Parameter‐Optimized Meta‐Lens and Frequency‐Domain Reconstruction 0.52
Dendritic Cell‐Based Biohybrid Immunomodulator Alleviates Intestinal Inflammatory Disease 0.43
Spatiotemporal Charging Single‐Atom Nanozymes Activated Pyroptosis for Antitumor Immunotherapy via Bioorthogonal Disruption of Succination and Reinvigorating T Lymphocytes 0.48
2 0.41
Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice 0.19
Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis 0.22
9 1.84
Structure-Guided Development of Genotype-Specific Recombinant Antibodies for Rapid Norovirus Detection via Dual-Mode Immunoassays 0.06
Pathology-Responsive Nanoprobes for NIR-II Imaging of Acute Kidney Injury 0.29
String-Powered Microfluidic Chip Integrating Heparin-Mediated One-Pot RT-RPA/CRISPR-Cas12a for Multiplex Detection of HFMD Viruses 0.55
Tandem Mass Spectrometry Fingerprint Tags (TMSFT) Applied for Early Gestation Noninvasive Prenatal Detection of Single-Gene Disorders 0.06
Preclinical Evaluation of Rationally Designed Peptide-NIRF Probe for c-Met Positive Liver Cancer Imaging-Guided Surgery 0.13
Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure 0.17
Deep Learning-Assisted Lens-Free Holography Integrated Pd Nanozyme-Armed Phages for the Rapid and Extraction-Free Detection of Viable Bacteria 0.13
Apoptotic Body-Hitchhiked Manganese-Based Biomimetic Nanoprobe for Sensitive Magnetic Resonance Imaging of Bacteria Triggering Peritoneal Dialysis-Associated Peritonitis In Vivo 0.25
Construction of Flexible Electrochemical Sensing Interfaces Based on Paper/PEDOT:PSS for the Detection of Cystatin C 0.21
8 1.45
Visualizing Senescent–Normal Cell Boundaries Through Environment‐Dependent Bidirectional Luminescent Contrast 0.07
Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1 0.05
Enhancing Superlubricity and Wear Resistance in Mechanically Robust Hydrogel via Microliter‐Scale Subsurface‐Initiated Polymer Brush Grafting 0.25
Dual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation 0.28
Molecular Rotor‐Based NIR‐II TICTgens for Mitochondria‐Targeted Pyroptosis Induction and Multi‐Model Monitoring of Cancer Immunotherapy 0.33
Exercise Modulates Exocytosis: Chemical Insights from the Intracellular Vesicle Perspective 0.04
Heavy‐Atom‐Free Supramolecular Photosensitizers Derived from Conventional Fluorophores 0.38
pH‐Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy 0.06
2 0.04
A brain-driven neural circuit contributes to tissue regeneration in joint cartilage 0.01
Autoantibody reactome analysis reveals diagnostic biomarkers and molecular classification for relapsing polychondritis 0.03
6 0.24
Integrative Multi‐omics Approaches Identify Biomarkers Associated with Progression from Arthralgia to Rheumatoid Arthritis 0.02
Landscape of Somatic Mutations in a Large Cohort of Chinese Patients With Immune Dysregulations 0.00
Toll‐like receptor 8 is a therapeutic target in rheumatoid arthritis 0.03
TWIST1-Mediated Induction of AEBP1 in Fibroblast-Like Synoviocytes Activates Transforming Growth Factor β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis 0.07
A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis 0.07
Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target 0.04
2 0.47
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration 0.08
Systematic profiling reveals betaine as an exercise mimetic for geroprotection 0.40
4 1.39
Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury via the microbial-host isozyme DPP4 0.07
Human monoclonal antibodies isolated after seasonal vaccination broadly neutralize antigenically drifted influenza B viruses 0.02
Discovery of human gut phage-encoded anti-CRISPR proteins unveils diverse mechanisms for phages to evade type II CRISPR immunity 0.92
Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy 0.38
3 0.56
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism 0.54
Ketogenic diet alleviates septic lung injury via microbial gut-lung axis 0.01
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression 0.00
2 0.90
Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system 0.75
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis 0.15
4 0.79
A light-activated nickel(ii)–antibiotic conjugate for synergistic antibacterial therapy 0.24
An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis 0.04
Chain-engineered tetraphenylethylene derivatives for potent antimicrobial activity against pathogens 0.18
A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of Helicobacter pylori infection 0.33
1 0.60
An extrinsic enzyme-activatable fluorescent probe for high-contrast tumor imaging 0.60
1 0.09
Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity. 0.09
1 0.32
Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID 0.32
2 0.08
Mobilization of the Environmental Toxicant Chlorpyrifos during Weight Loss and Its Impact on Liver and Adipose Tissue Metabolism in Mice 0.04
Mobilization of the environmental toxicant chlorpyrifos during weight loss and its impact on liver and adipose tissue metabolism in mice. 0.04
7 2.74
Residues, Influencing Factors, and Health Risk Assessment of Phthalate Esters (PAEs) in Major Crops from a Tropical Island in China 0.02
Profiling Hydrophobic Organic Pollutants in Serum from Vulnerable Populations in Dalian, China 0.81
Is Reproductive Toxicity of Bisphenols an Adverse Outcome from Insulin Homeostasis Disruption in Fish? 0.48
Synergistic Exposure to Endocrine-Disrupting Chemicals in Pediatric Lungs: Epidemiological Drivers and Disease-Associated Variations 0.04
Responses of zebrafish to phthalate exposure and recovery: Insights into transcriptome-based molecular mechanisms 0.25
Perfluorooctane sulfonate exposure disrupts steroid hormone synthesis in rats via the gut-metabolism-testis axis 0.78
Environmental levels of bis(2-ethylhexyl)-tetrabromophthalate (TBPH) cause thyroid toxicity and early carcinogenic signals in juvenile fish 0.36
1 0.22
2,4,6-Tri-tert-butylphenol Promoted Adipogenesis in 3T3-L1 Cells through a Retinoid X Receptor α-Dependent Mechanism 0.22
13 3.75
miR-184/hamp-Mediated Cardiotoxicity and Hepatotoxicity in Offspring Zebrafish Following Paternal Exposure to Environmentally Relevant Concentrations of Tris(1,3-dichloro-2-propyl) Phosphate 0.11
Gut Microbiota Mediates HFPO–DA-Induced Hepatotoxicity via Arginine Reprogramming in Lean NAFLD Mice 0.13
Exposure Profile and Combined Effects of Human PPARγ Agonists in Residential Indoor Dust from China 0.42
Far-UVC (222 nm) Suppresses Bacterial UV Resistance and Repair through Inhibition of DNA Repair Pathways 0.02
Combining Suspect Screening with Large Language Model-Based Text Mining to Comprehensively Characterize Organic Compounds in Human Milk Associated with Pregnancy Complications 0.35
Tetrabromobisphenol S (TBBPS) Causes Non-Negligible and Multigenerational Reproductive Toxicity in Zebrafish 0.18
Exposure to a GenX Homologue Results in Sexually Dimorphic Bile Acid Metabolism Disorders Mediated by Hepatic PPARα in Mice 0.04
Interfacial Stabilization of Cu(I) in Ultralow-Dose Cu2O/ZIF-8 Heterojunctions Enabling Rapid and Energy-Efficient Genomic Disruption of Pathogens 0.69
Translocation and Tissue Distribution of Bisphenol AF and Its Transformation Products in Pumpkin Seedlings 0.36
Tetrabromobisphenol A Induces Neurotoxicity in Adult Zebrafish: Insights from the Gut Microbiota-Bile Acid-Brain Axis 0.80
Screening and Evaluation of Male Reproductive Effects of Isothiazolinones at Human-Relevant Levels in Mammals: Direct Impairments and Increased Susceptibility to Subsequent Spermatogenic Stress 0.50
Microbial Dysbiosis in the Lung and Gut in Response to Inhalable Particulate Matters in Pneumoconiosis Patients and Animals 0.08
Aryl Organophosphate Esters and Hemostatic Disruption: Identifying Risk through Machine Learning and Experimental Validation 0.07
2 0.08
Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity 0.03
Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts 0.05
2 0.10
Myeloid CD36 deficiency alleviates hepatic fibrosis by promoting adaptive immunity of macrophage. 0.05
Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus Immunotherapy and targeted therapy in HCC. 0.05
2 0.61
Label-supervised surgical instrument segmentation using temporal equivariance and semantic continuity 0.05
Visual Anomaly Detection for Reliable Robotic Implantation of Flexible Microelectrode Array 0.56
1 0.03
Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth 0.03
1 0.04
Mortality risk associated with general and central obesity in inflammatory bowel disease patients: a long-term prospective cohort study 0.04
1 0.01
Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence 0.01
1 0.01
Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma 0.01
2 0.88
Small RNA ASpks2 promotes Mycobacterium tuberculosis survival in macrophages via targeting polyketide synthase 2 0.58
Temperature downshifts induce biofilm formation in Pseudomonas aeruginosa through the SiaABCD signal and functional module 0.30
2 0.28
A protein-based pneumococcal vaccine elicits broad immunity associated with multifunctional antibody responses in humans 0.21
BAF60a-dependent chromatin remodeling preserves β-cell function and contributes to the therapeutic benefits of GLP-1R agonists 0.07
1 0.13
Fullerene for Reducing Acute Radiation Dermatitis in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Phase II, Double-Blind, Randomized Controlled Trial. 0.13
1 0.03
Xbp1 controls the reparative function of intestinal ILC2s during colitis 0.03
2 0.79
Divergent pathogenesis of two Chinese Crimean–Congo hemorrhagic fever viruses in cynomolgus macaques 0.63
Middle East Respiratory Syndrome Coronavirus–Specific T-Cell Responses in Dromedary Camel Abattoir Workers in Nigeria Suggests Frequent Zoonotic Spillover 0.17
3 0.11
Amelioration of Symptomatic Alzheimer’s Disease after Selective Impairment of p75NTR Function in Adult Forebrain Excitatory Neurons 0.01
Altered regional brain activity underlying the higher postoperative analgesic requirements in abstinent smokers: A prospective cohort study 0.07
Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles 0.03
1 0.17
KLRB1 and IL12RB1 are pretherapeutic predictors of time to relapse in patients of psoriasis treated with IL-17 blockade 0.17
3 0.23
A “Lung-Trap” Theranostic Strategy for Precision Management of Drug-Resistant Bacterial Pneumonia and Bacteremia 0.10
Chirality-Driven Metal–Phenolic Artificial Enzymes Enable Renal Targeting and Antioxidative Therapy Enhancement for Acute Kidney Injury 0.10
Unanticipated Quinoline Modification on Vancomycin as an Effective Strategy to Alter the Antibacterial Profile and Combat Multidrug Resistance 0.03
1 0.06
An immunosuppressive tertiary lymphoid structure is associated with adverse prognosis in gastric-type endocervical adenocarcinoma 0.06
1 0.12
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma 0.12
16 2.22
Stable depression subtypes identified using functional connectome normative deviation models and their response to rTMS 0.04
Heterogeneous functional state dynamics and its structural substrates in male individuals with autism spectrum disorder 0.00
Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study 0.03
The Cognitive benefits of nitrate in patients with alcohol use disorder: unraveling the oral microbiome ectopic colonization pathway 0.00
Methamphetamine induces long-lasting dysbiosis of the gut microbiota 0.26
Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression 0.00
Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors 0.17
Astroglial kappa opioid receptor-mediated reduction of glutamate exchanger xCT in the prelimbic cortex underlies chronic stress-induced depressive-like behaviors 0.28
Unraveling sexually dimorphic offspring behaviors: maternal premating stress and the neuro-microbial-metabolic network 0.38
Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine 0.00
Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit 0.16
Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobe 0.06
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents 0.16
Characteristics of brain network connectome and connectome-based efficacy predictive model in bipolar depression 0.25
Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions 0.04
Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer 0.39
1 0.44
Dual Chemical Regulations for Combined Anti-Resorption and Osteo-Anabolism to Reverse Osteoporosis 0.44
5 0.50
Multiplexed magnetic resonance imaging 0.01
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity 0.03
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity 0.07
Psychedelics elicit their effects by 5-HT receptor-mediated G signalling 0.09
Adenosine signalling drives antidepressant actions of ketamine and ECT 0.31
1 0.20
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment 0.20
64 13.18
Highly potent C-type nanoantibodies neutralize Nipah and Hendra viruses by cavity filling on fusion glycoprotein 0.36
Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans 0.36
Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects 0.11
Double-stranded RNA and ROS scavenging nanoplatform for modulating skin inflammation 0.02
A RIG-I targeting nanozyme induces PANoptosis for cancer immunotherapy 0.16
Host serum-circulating flavivirus NS1 co-opts mosquito miRNA processing to suppress early immune defense 0.45
Lifestyle-dependent evolution and CtrA-mediated lifestyle transitions shape phage resistance in marine Roseobacter 0.78
Generation of an autophagy-targeting influenza A virus as live attenuated vaccine 0.79
RAISE: A computational tool for evaluating sarbecovirus spillover potential 0.03
Structures of dye-bound transthyretin amyloid fibrils from abdominal fat biopsies 0.37
Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks 0.28
Small nucleolar RNA drives self-renewal of intestinal stem cells via initiation of transcription 0.76
Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse 0.01
Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum 0.14
Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model 0.05
Biological valorization of methane and nitrogen gas-derived ammonia via methanotrophic bacteria for gut-beneficial nutrients 0.10
Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses 0.02
Proteomics-based machine learning model for predicting secondary infection in HBV-related liver failure 0.08
A synthetic system for RNA-responsive pyroptosis based on type III-E CRISPR nuclease-protease 0.25
Discovery of antimicrobial peptides targeting via a pre-trained and fine-tuned few-shot learning-based pipeline 0.15
Automated diagnostic of cervical spondylosis on multimodal medical images with a multi-task deep learning model 0.18
Prefrontal chandelier cells encode stimulus salience to influence learning in male mice 0.01
Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation 0.35
Domain-specific schema reuse supports flexible learning to learn in the primate brain 0.58
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice 0.65
Endothelial IRE1α promotes thrombospondin-1 mRNA decay and supports metabolic stress adaptation of pancreatic islets 0.08
Co-occurrence of diverse defense systems shapes complex microbe-virus relationships in deep-sea cold seeps 0.09
A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice 0.07
Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism 0.01
Tracing the origin of myofibroblasts in kidney fibrosis 0.10
Utilizing nanoinducers for precision degradation of bacterial protein to mitigate antibiotic resistance 0.57
Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera) 0.10
Development of a replication-defective mpox virus platform for fundamental and therapeutic research 0.06
Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset 0.02
A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma 0.44
Pathogenicity, virological features, and immune evasion of SARS-CoV-2 JN.1-derived variants including JN.1.7, KP.2, KP.3, and KP.3.1.1 0.03
A corticospinal signature for interindividual pain sensitivity 0.19
Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis 0.16
Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation 0.32
Carboxymethylcytosine is a natural base modification and a handle for bacteriophage DNA hypermodification 0.06
Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function 0.02
Anti-phage defense mechanism involving phage-encoded DNA binding protein and bacterial reverse transcriptase DRT4 0.29
A niche-dependent redox rheostat regulates epithelial stem cell fate 0.05
Unraveling the mechanism behind the probable extinction of the B/Yamagata lineage of influenza B viruses 0.01
Flexible Use of Limited Resources for Sequence Working Memory in Macaque Prefrontal Cortex 0.38
Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitis 0.10
Polygenic risk score and cluster-based analysis suggests links between type 2 diabetes and vascular dementia in the KARE study 0.03
Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity 0.15
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database 0.00
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model 0.24
Crotonate enhances intestinal regeneration after injury via HBO1-mediated H3K14 crotonylation 0.08
Rising dengue risk with increasing El Niño–Southern Oscillation amplitude and teleconnections 0.07
Granzyme B activated near-infrared-II ratiometric fluorescent nanoprobe for early detection of tumor response to immunotherapy 0.13
Trait anxiety is associated with reduced reward-related replay at rest 0.02
Designed optogenetic tool for bridging single-neuronal multimodal information in intact animals 0.37
Crosstalk between inovirus core gene and accessory toxin-antitoxin system mediates polylysogeny 0.58
Mechanism of substrate recognition and release of human SGLT2 0.23
Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking 0.04
Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA 0.13
Molecular mechanism of drug inhibition of URAT1 0.21
Positional BMP signaling orchestrates villus length in the small intestine 0.09
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression 0.06
A molecularly defined brain circuit module for regulating panic-like defensive state 0.16
Distinct neural population code and causal roles of primate caudate nucleus in multimodal decision-making 0.40
2 0.09
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 0.08
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study 0.00
2 0.49
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases 0.08
TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice 0.42
1 0.41
Bioengineered photosynthetic nanothylakoids reshape the inflammatory microenvironment for rheumatoid arthritis therapy 0.41
3 0.31
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability 0.02
Charting brain morphology in international healthy and neurological populations 0.01
A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors 0.28
1 0.09
A nanobody-based therapeutic targeting Nipah virus limits viral escape 0.09
5 1.10
Human hippocampal ripples prioritize model-based learning 0.08
A septal inhibitory circuit constrains alcohol reward and mediates liraglutide’s suppressive effects on alcohol intake in mice 0.23
Alteration of cellular representation in the central amygdala mediates stress-induced analgesia in mice 0.71
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits 0.01
Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples 0.06
3 0.57
Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms 0.07
Neural variability reliably encodes interindividual differences in the perception of pain intensity 0.44
The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input 0.06
1 0.08
Transcription factor ZEB2 is essential for ureteral smooth muscle cell differentiation 0.08
11 2.75
Perception of a bacterial quorum sensing signal activates a tripartite plant immune strategy 0.64
A farnesol-sensing triad in Pseudomonas aeruginosa drives interkingdom predation on Candida albicans via signal transduction 0.05
Personalized functional topography–based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression 0.00
Genetic recording of pancreatic beta cell proliferation 0.19
Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system 0.02
Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis 0.20
SPNS1 is an essential cellular factor for EV-A71 by acting as a transporter of viral pocket factor 0.22
Asparagine endopeptidase prompts breast cancer–related pericardial calcification by regulating IGF2 and integrin αvβ5 0.14
Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation 0.05
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition 0.75
Genetic contributions to brain criticality and its relationship with human cognitive functions 0.50
2 0.10
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation 0.07
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus 0.03
8 2.27
P2X7R of synovial fibroblasts is a potential therapeutic target associated with refractory rheumatoid arthritis 0.02
Phosphorylation of PfiA modulates Pf4 phage production through PfiA/PfiT stoichiometric reconfiguration in Pseudomonas aeruginosa 0.50
Animal-associated jumbo phages as widespread and active modulators of gut microbiome ecology and metabolism 0.28
SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes 0.03
Microbiota metabolite taurodeoxycholic acid maintains intestinal tissue residency of innate lymphoid cells via engagement with P2Y10 receptor 0.72
Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease 0.10
Adaptive reward representations integrate expected uncertainty signals in orbitofrontal cortex 0.08
Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus 0.55
8 1.33
Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models 0.35
Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice 0.19
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models 0.15
snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice 0.01
An epitope vaccine derived by analyzing clinical trial samples safeguards hosts with prior exposure to S. aureus against reinfection 0.11
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis 0.10
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors 0.27
A host defense peptide–mimicking prodrug activated by drug-resistant Gram-negative bacterial infections 0.15
2 0.63
Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition. 0.12
Macrophages form dendrite-like pseudopods to enhance bacterial ingestion 0.52
2 0.11
Gut microbial production of lithocholic acid reprograms pro-resolutive macrophages to enhance vedolizumab responsiveness via the TGR5/FXR-NF-κB axis 0.08
Global distribution of α/β hydrolase family macrolide esterases in Gram-positive bacteria 0.03
1 0.44
CB2R-cAMP-Epac1 Pathway Orchestrates Epithelial-Neural-Immune Interactions in Atopic Dermatitis 0.44
1 0.01
Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China 0.01
1 0.38
Responses of Viral Communities in Aerobic Biofilms under Antibiotic Stress 0.38

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