Clinical Sciences articles for University of Toronto (U of T), Canada

Time frame: 1 June 2025 - 30 May 2026

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Count: 211

Article ‘Count’ for Clinical Sciences.

Journal Count Share
1 0.04
Ultrasmall Surface-Charge-Modified Tantalum Oxide Nanoparticles for the Assessment of Articular Cartilage Using Contrast-Enhanced Computed Tomography 0.04
2 2.00
THE EFFECT OF PERFUSION WITH AND WITHOUT MECHANICAL LOADING ON AN IN VITRO MODEL OF THE OUTER ANNULUS FIBROSUS-CARTILAGE ENDPLATE INTERFACE 1.00
Biodegradable sodium citrate-treated hyaluronic acid microspheres for genicular artery embolization 1.00
1 0.33
Association of frailty with healthcare utilization and days alive at home in patients with gynecologic cancers: a population-based study 0.33
1 0.55
Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages 0.55
5 0.81
Early mechanical reperfusion in high-risk pulmonary embolism supported by V-A ECMO: a multicenter international cohort study 0.02
Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS) 0.42
Physiological Consequences of Breathing Effort According to the Mode of Ventilation During Acute Hypoxemic Respiratory Failure. 0.10
Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation (RESCUE-3). 0.05
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome 0.22
1 0.55
Toward “Receive-Only” Nuclear Magnetic Resonance Complementary Metal-Oxide-Semiconductor Microcoil Arrays for High-Throughput Analysis of Environmental Samples 0.55
7 2.33
Evaluating The Statistical Robustness Of Randomized Controlled Trials Of Spinal Cord Stimulation For Pain Through The Use Of Fragility Index. 0.05
Pain as a driver of myocardial injury in hip fracture patients: a HIP fracture Accelerated surgical TreaTment And Care track (HIP ATTACK) Trial secondary analysis. 0.05
Sedation-Related Electroencephalographic Patterns in Acute Hypoxemic Respiratory Failure. 0.37
Evaluation of the potential for lung recruitment with the Recruitment-to-Inflation ratio during general anesthesia. 0.02
The association between preoperative depression and length of stay after major surgery: a systematic review and meta-analysis. 0.64
Analgesic benefits of motor-sparing fascial plane blocks in comparison to periarticular local infiltration analgesia for total hip arthroplasty: A network meta-analysis. 0.21
Ketamine-induced sustained modulation of GABAA receptor function in mouse hippocampal neurons following anesthesia. 1.00
1 0.14
Derivation and Validation of a Clinical Rule to Detect Bacteremia Versus Contaminants in Positive Pediatric Blood Cultures: A Retrospective Cohort Study 0.14
3 0.19
Effect of Nonmedical Cannabis Legalization and Exposure to Retail Stores on Cannabis Harms : A Quasi-experimental Study. 0.14
Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study. 0.02
Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis. 0.04
2 0.18
A Prospective, Randomized, Multicenter Trial Comparing Lactated Ringer's Alone or With 5% Albumin for Resuscitation of Large Burns The Acute Burn ResUscitation Multicenter Prospective Trial 2 (ABRUPT2). 0.08
A Multicenter Randomized Controlled Trial on the Surgery of Fractured Ribs: The SOFRIB Trial. 0.10
8 3.87
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study 0.04
Psoriatic dactylitis: the association with HLA genetic susceptibility markers 0.87
Antimitochondrial antibodies in systemic lupus erythematosus are associated with and predict nephritis, arterial vascular events, and mortality 0.07
CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study 0.70
Understanding the drivers of BASDAI and back pain scores in psoriatic arthritis 1.00
SLE classification criteria item relationships: implications on SLE as a disease entity 0.20
A glossary of signs and symptoms of giant cell arteritis 0.07
Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus 0.93
12 3.52
Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis within a Longitudinal Cohort 0.78
High‐resolution deep learning DIXON MRI of the sacroiliac joints is non‐inferior to standard MRI in patients with suspected axial Spondyloarthritis 0.04
Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study 0.02
Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept Study 0.08
Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study 0.85
The impact of non‐steroidal anti‐inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: 10‐year results from an inception cohort 0.06
Toward a treat‐to‐target strategy in juvenile dermatomyositis: what are the suitable targets and optimal timing of their achievement? 0.32
Effect of time to start of biologic therapy on treatment response in childhood arthritis: Results from the UCAN CAN‐DU study 0.11
Clinical Impact of Multiparametric Contrast‐Enhanced Dual‐Energy Computed Tomography in Arthritis Imaging: A Prospective Single‐Center Study 0.05
Differences in IgG Sialylation Distinguish Asymptomatic from Symptomatic Anti‐Nuclear Antibody Positive Individuals 0.96
Three‐Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular scpJIA/scp Consensus Treatment Plans Study 0.22
A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis 0.03
1 0.36
Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer’s disease 0.36
1 0.14
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi 0.14
3 1.45
Antimicrobial Treatment of Mild Mycobacterium avium Complex Pulmonary Disease Predicted to Increase Survival and Quality-Adjusted Life Years 0.60
Low tidal volume ventilation and mortality in patients with acute brain injury: a secondary analysis of an international observational study* 0.60
Anomalous differences between the Global Lung Function Initiative 2023 and 2012 spirometry reference values 0.25
2 0.03
Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial 0.01
High-Dose vs. Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis. 0.02
2 0.26
Duration of Therapy for Pseudomonas aeruginosa Bacteremia—A Post Hoc Subgroup Analysis From the BALANCE Randomized Controlled Trial 0.21
Indirect Influenza Vaccine Effectiveness Under Randomized Conditions: A Systematic Review and Meta-Analysis 0.04
13 3.89
Survey of Intensivist Coverage and Interprofessional Team Staffing in Canadian ICUs 0.34
Prone Positioning in a North American Cohort of Hypoxemic Patients on Mechanical Ventilation 0.05
Artificial Intelligence Algorithm to Monitor Inspiratory Muscle Effort and Patient-Ventilator Dyssynchrony During Mechanical Ventilation 0.13
Association Between Sex and Clinical Outcomes for Critically Ill Patients in India: A Registry-Embedded Cohort Study 0.20
Defining the Resolution of Acute Respiratory Distress Syndrome: A Delphi Consensus Study. 1.00
Sex-Specific Differences in Tidal Volumes and Mortality of Mechanically Ventilated Patients. 0.73
Identifying Research Priorities in Canadian Adult and Pediatric Critical Care: Results From a James Lind Alliance Priority Setting Partnership. 0.03
Association of Prolonged Emergency Department Length of Stay With Process of Care Measures for Critically Ill Patients. 0.88
Acute Respiratory Distress Syndrome in Trauma 2007-2019: Comprehensive Patient and Center-Level Retrospective Cohort Analysis. 0.07
Variability in Venovenous Extracorporeal Membrane Oxygenation Candidacy Decision-Making: An International Survey. 0.14
Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome. 0.12
Persistent Critical Illness Among Intensive Care Patients in India: A Registry-Embedded Cohort Study. 0.13
Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy 0.06
3 2.05
Psilocybin induces sex- and context-specific recruitment of the stress axis 0.08
Neurogenesis-dependent transformation of hippocampal memory traces during systems consolidation 0.97
A history of injury enhances affective and sensory responses to predator threat by sensitizing corticosterone release through TRPA1 receptor signaling 1.00
1 0.80
Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process 0.80
3 0.64
Everyone or Just Some? Cost-Effectiveness of General Population Versus Targeted Screening Strategies for Type 1 Diabetes in Canada. 0.20
Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease. 0.39
Benefit of Semaglutide in Symptomatic Peripheral Artery Disease by Baseline Type 2 Diabetes Characteristics: Insights From STRIDE, a Randomized, Placebo-Controlled, Double-Blind Trial. 0.05
1 0.19
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies 0.19
1 0.20
Multiphase OH Oxidation of Bisphenols: Chemical Transformation and Persistence in the Environment 0.20
1 0.04
Duration of Androgen Suppression with Postoperative Radiotherapy (DADSPORT) for Nonmetastatic Prostate Cancer: A Collaborative Systematic Review and Meta-analysis of Aggregate Data 0.04
4 0.21
Recommendations for the Evaluation and Management of Inflammatory Bowel Disease With Irritable Bowel Syndrome–Like Symptoms: A Joint Rome Foundation and International Organization for the Study of IBD (IOIBD) Consensus 0.08
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis 0.06
Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn’s Disease Recurrence 0.04
Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation 0.04
1 0.20
Lambdoid phages with abundant Chi recombination hotspots reflect diverse viral strategies for recombination-dependent growth 0.20
2 0.24
Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials 0.24
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia 0.01
2 0.73
Understanding hepatopancreatobiliary cancer risks in a population-based primary sclerosing cholangitis-inflammatory bowel disease cohort. 0.63
Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort. 0.11
1 0.30
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity 0.30
1 0.50
School opening associated with lower test-adjusted COVID-19 case rates in children 0.50
3 1.19
Long-Term Trends in Pediatric Self-Injury in High-Income Countries 0.90
Clinical Signs Associated With Mortality and Sepsis in Young Infants 0.09
Acceptance and Commitment Therapy–Based Parenting Program in Children With Co-Occurring Asthma and ADHD 0.20
4 0.35
One-Year Actigraphy Study of Sleep and Rest-Activity Rhythms as Markers of Relapse in Depression 0.13
Mental Disorders as a Risk Factor of Acute Coronary Syndrome 0.12
Measures of General Intelligence and Risk for Alcohol Use Disorder 0.10
Framework for Brain-Derived Dimensions of Psychopathology 0.02
2 0.70
A Population-Level Evaluation of Emergency General Surgery Models of Care and Clinical Outcomes 0.27
A Predictive Tool for Ability to Remain at Home After Cancer Surgery in Older Adults 0.44
4 0.27
Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery 0.02
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury 0.21
Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis 0.04
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score 0.01
2 1.45
Periprosthetic Joint Infection Following Total Knee Arthroplasty Is Associated with a Significantly Elevated Risk of Mortality: A Population-Level Database Study. 0.70
A Dedicated Trauma Operating Room for Hand Surgery Reduces After-Hours Cases and Costs without Affecting Wait Times: A Retrospective Single-Center Cohort Study. 0.75
3 0.24
Utilization of liver grafts obtained from donation after medical assistance in dying: A Canadian multicenter experience 0.16
Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis 0.04
Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis 0.04
6 1.35
Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study 0.30
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia 0.02
Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant Pseudomonas aeruginosa 0.54
Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial 0.01
Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool 0.33
Priming or Boosting iPlasmodium falciparum/i Transmission-Blocking Responses With Recombinant Vaccines or Gametocyte Extract 0.15
2 1.23
The tuned cortex: Convergent expertise-related structural and functional remodeling across the adult lifespan 0.90
Is the whole the sum of its parts? Neural computation of consumer bundle valuation in humans 0.33
8 5.36
Late adverse cardiovascular events after aortic valve-sparing operations in patients with Marfan Syndrome 1.00
Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation 1.00
Sex-specific outcomes after thoracic aortic surgery 0.07
Impact of normothermic regional perfusion on ex vivo lung perfusion outcomes in donation after circulatory death lung donors 0.31
More is not better: The role of the leukocyte filter in ex vivo lung perfusion 1.00
Improving timely transplantation while reducing cancellation of scheduled surgery 0.81
1,000 Cases of Ex Vivo Lung Perfusion for Lung Transplantation: A Single Centre Experience 1.00
Diagnostic Effectiveness and Safety of Robotic-Assisted Bronchoscopy for Subsolid Pulmonary Nodules – A Multicenter, Prospective, Observational Study 0.17
1 0.02
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis 0.02
2 0.11
Perioperative Management in Nail Surgery: An International Delphi Consensus Statement 0.08
Establishment of standardized definitions and a core set of outcome characteristics following hidradenitis suppurativa surgery developed by an expert Delphi consensus 0.03
1 0.06
Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B 0.06
7 2.09
Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection: A Multicentre, Pragmatic, Randomized Trial—Vanguard Results 0.67
The Association Between Hospital Harms and 1‐Year Mortality Following a Hip Fracture in Ontario, Canada: A Cohort Study 0.53
<atl>Variation in Psychotropic and Non‐Psychotropic Prescribing in Nursing Homes: A Multi‐Level scpEMR/scp ‐Based Retrospective Cohort Study</atl> 0.10
Association of Geriatric Consult Services With Geriatric Processes of Care and Clinical Outcomes in US Trauma Centers 0.05
Predictors of Advance Directive Changes in Ontario Nursing Home Residents: A Case–Control Study 0.25
Effectiveness of Exercise in Older Adults Discharged From the ER After Minor Injuries: The CEDeComS Stepped-Wedge Trial 0.17
Potential Overtesting of Nursing Home Residents With Diabetes in Ontario, Canada 0.33
3 0.21
Erythroid ACKR1 Deficiency Aggravates Immune-Mediated Kidney Disease. 0.05
Predictive Value of the Oxford Classification for the Effect of Glucocorticoid Therapy in IgA Nephropathy. 0.09
Kidney Parameters with Tirzepatide in Obesity with or without Type 2 Diabetes. 0.08
4 0.37
Genetic testing in kidney transplantation and living kidney donor risk assessment 0.04
Reduced podocyte stiffness is a feature of proteinuric kidney disease 0.16
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy 0.13
The enzyme SMPDL3b in podocytes decouples proteinuria from chronic kidney disease progression in experimental Alport Syndrome 0.04
7 1.21
Dynamic interactions between gut microbiome and host lipidome in antenatal depression: a large longitudinal study 0.04
Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors 0.03
Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis 0.03
Homeostatic scaling ensures behavioural stability during corticosterone negative feedback 0.08
Deliberate self-harm and suicide in individuals with cannabis-related hospital contacts in Ontario, Canada 0.02
MAO-B status in alcohol use disorder: a [11C]SL25.1188 PET imaging study of putative astrogliosis 0.90
Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit 0.11
3 1.73
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones 0.03
A pore-forming antiphage defence is activated by oligomeric phage proteins 1.00
Prophages block cell surface receptors to preserve their viral progeny 0.70
11 3.65
Multiomics characterization of acute child illness and mortality in Africa and South Asia 0.01
A deep representation learning model to predict response to vagus nerve stimulation 0.47
A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity 0.25
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations 0.02
PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis 0.89
Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites 0.02
Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models 0.83
Molecular cartography of the human down syndrome and trisomic mouse brain 0.95
DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge 0.05
Estimation-uncertainty affects decisions with and without learning opportunities 0.17
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge 0.00
1 0.03
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling 0.03
6 1.13
Deleterious coding variation associated with autism is shared across ancestries 0.01
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 0.42
Feasibility, acceptability and clinical outcomes of the BabyScreen+ genomic newborn screening study 0.01
Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial 0.07
Adjunct-to-insulin therapy using SGLT2 inhibitors in youth with type 1 diabetes: a randomized controlled trial 0.59
An international Delphi consensus for reporting of setting in psychedelic clinical trials 0.03
3 1.90
Closed-loop stimulation modulates attention shifting in children 0.88
Microglia-dependent regulation of fear memory extinction 0.98
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability 0.05
3 1.68
Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex 0.04
Molecular mechanisms mediating engram ensemble retrievability state in mice 0.81
PV-dependent reorganization of prelimbic cortex sub-engrams during systems consolidation 0.83
2 0.63
Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study 0.47
Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study 0.17
5 2.62
Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation 0.98
NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium 0.93
Identification of somatostatin+ inhibitory engrams for extinction in the basolateral amygdala 0.05
De novo design of potent inhibitors of clostridial family toxins 0.58
Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission 0.07
2 0.02
Standalone Endovascular Embolization versus Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations in Eloquent Brain. 0.01
Impact of LI-RADS CT and MRI Ancillary Features on Diagnostic Performance: An Individual Participant Data Meta-Analysis. 0.01
1 0.78
The discovery of a Legionella phage explains a key determinant of human disease 0.78
2 1.01
AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy 0.66
Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis 0.35
1 0.06
Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis 0.06
2 0.08
Remibrutinib in chronic spontaneous urticaria: 52-Week results from two phase 3 studies 0.05
Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis 0.03
6 0.37
Enpatoran, a Toll-like receptor 7/8 inhibitor, in moderate-to-severe systemic lupus erythematosus: findings from Cohort B of a multicentre, international, double-blind, placebo-controlled dose-finding phase 2 trial 0.07
Survivorship of modern total hip replacement to 30 years: systematic review, meta-analysis, and extrapolation of global joint registry data 0.19
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on oral antiretroviral therapy: 48-week results of a phase 3, multicentre, randomised, open-label, non-inferiority trial 0.05
Surgical fixation versus non-surgical care for children with a displaced medial epicondyle fracture of the elbow (the SCIENCE study): a multicentre, randomised controlled, superiority trial and economic evaluation 0.01
Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis 0.02
Once-daily oral icotrokinra versus placebo and once-daily oral deucravacitinib in participants with moderate-to-severe plaque psoriasis (ICONIC-ADVANCE 1 & 2): two phase 3, randomised, placebo-controlled and active-comparator-controlled trials 0.03
2 1.03
Once-weekly semaglutide 7·2 mg in adults with obesity and type 2 diabetes (STEP UP T2D): a randomised, controlled, phase 3b trial 0.03
The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada 1.00
1 0.50
Strategies to reduce antimicrobial resistance in newborns in low-income and middle-income countries: a systematic review and meta-analysis 0.50
1 0.07
Safety and effectiveness of the Walk ‘n Watch structured, progressive exercise protocol delivered by physical therapists for inpatient stroke rehabilitation in Canada: a phase 3, multisite, pragmatic, stepped-wedge, cluster-randomised controlled trial 0.07
1 0.95
MRI-guided adaptive radiotherapy for high grade glioma (UNITED): a single-centre, single-arm, non-inferiority, phase 2 trial 0.95
2 0.51
Confirmatory efficacy and safety trial of magnetic seizure therapy versus right unilateral ultra-brief electroconvulsive therapy in depression (CREST–MST): a randomised, double-blind, non-inferiority trial in Canada and the USA 0.44
First-episode psychosis and substance use involvement across birth cohorts in Canada: a retrospective longitudinal population-based study 0.07
9 0.75
Decompression with or without Duraplasty for Chiari I and Syringomyelia 0.01
Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock 0.02
Finerenone in Type 1 Diabetes and Chronic Kidney Disease 0.05
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes 0.04
Selective Decontamination of the Digestive Tract during Ventilation in the ICU 0.31
Belzutifan for Advanced Pheochromocytoma or Paraganglioma 0.04
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes 0.05
Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation 0.19
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline 0.05
1 0.08
Guideline-based prognostic factors associated with mortality in pulmonary embolism: a systematic review and meta-analysis 0.08

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