Angiogenic Factors in Gastric Cancer Dynamics
Summary
Angiogenesis is a defining feature of gastric cancer progression, enabling tumour growth, invasion and dissemination by supplying oxygen and nutrients through newly formed vasculature. Key mediators such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs) interact with hypoxia-inducible elements and inflammatory cytokines to orchestrate the angiogenic switch. Tumour-associated vessels exhibit structural and functional abnormalities, contributing to heterogeneous perfusion, elevated interstitial pressure and resistance to therapy. Insights into the temporal regulation of pro- and anti-angiogenic signals have informed the design of targeted agents and combination regimens aimed at normalising the vasculature, improving drug delivery and overcoming adaptive resistance. Advances in imaging modalities and molecular profiling continue to unravel the dynamic interplay between the tumour microenvironment and angiogenic networks, with global implications for patient stratification and personalised treatment.
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Angiogenic Factors in Gastric Cancer Dynamics publication trend
The graph below shows the total number of articles in angiogenic factors in gastric cancer dynamics across all publications each year (not limited to Nature Index journals).
Technical terms
Angiogenesis: Formation of new blood vessels from pre-existing vasculature, essential for tumour expansion and metastatic spread.
Vascular endothelial growth factor (VEGF): Family of signalling glycoproteins that stimulate endothelial cell proliferation, migration and permeability.
Microvessel density (MVD): Quantification of microvessels within tumour tissue, serving as a histological marker of angiogenic activity.
Angiopoietin–Tie2 pathway: Signalling axis in which angiopoietins bind the Tie2 receptor on endothelial cells to regulate vessel maturation and stability.
References
- Angiogenesis and Anti-Angiogenic Therapy in Gastric Cancer. International Journal of Molecular Sciences (2017).
- Gastric carcinogenesis: a comprehensive review of the angiogenic pathways. Clinical Journal of Gastroenterology (2020).
- Treatment Strategies of Gastric Cancer—Molecular Targets for Anti-angiogenic Therapy: a State-of-the-art Review. Journal of Gastrointestinal Cancer (2021).
- Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer. BMC Cancer (2010).
- Predictive Significance of Serum Level of Vascular Endothelial Growth Factor in Gastric Cancer Patients. BioMed Research International (2016).
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