Anti-Müllerian Hormone Applications in Reproductive Health Assessment
Summary
Anti-Müllerian hormone (AMH) is a glycoprotein secreted by granulosa cells of pre-antral and small antral follicles in the ovary. As a direct indicator of follicular pool size, AMH has become central to the assessment of ovarian reserve, fertility potential and reproductive lifespan. Its relative stability throughout the menstrual cycle and correlation with antral follicle count permit single-point sampling for counselling on family planning, anticipating ovarian response during assisted reproduction and guiding individualised treatment regimens. Beyond fertility prediction, AMH measurement informs on gonadotoxic risks in oncology, monitors ovarian function in chronic disease populations and aids differential diagnosis in paediatric and adult endocrinology. Advances in assay automation have enhanced throughput and precision, facilitating widespread clinical adoption. Emerging applications include evaluation of ovarian impact following surgical interventions, optimisation of gonadotrophin dosing and integration with imaging modalities to refine prognostic models. As both a research tool and a bedside biomarker, AMH underpins a broad spectrum of reproductive health strategies worldwide.
Research from Nature Portfolio
A prospective comparison of minimally invasive ovarian cystectomy platforms has shown that robotic-assisted and conventional laparoscopic approaches yield comparable preservation of ovarian reserve as measured by AMH. Despite longer operative times for the robotic system, pre- and post-operative AMH concentrations did not differ significantly between groups, indicating that both techniques afford equivalent protection of follicular integrity. These findings support the safety of advanced surgical platforms in benign ovarian surgery without compromising future fertility potential.
Anti-Müllerian Hormone Applications in Reproductive Health Assessment publication trend
The graph below shows the total number of articles in anti-müllerian hormone applications in reproductive health assessment across all publications each year (not limited to Nature Index journals).
Technical terms
Anti-Müllerian hormone (AMH): A peptide hormone secreted by ovarian follicles, serving as a biomarker of the remaining egg supply.
Ovarian reserve: The quantity and quality of oocytes available in the ovaries, indicative of reproductive capacity.
Enzyme-linked immunosorbent assay (ELISA): A laboratory method for detecting and quantifying hormones in blood samples using antibody-based reactions.
Antral follicle count (AFC): Ultrasound-based tally of small ovarian follicles reflecting the functional ovarian reserve.
References
- Contraceptive-specific antimüllerian hormone values in reproductive-age women: a population study of 42,684 women. Fertility and Sterility (2023).
- Changes in anti-Müllerian hormone values for ovarian reserve after minimally invasive benign ovarian cystectomy: comparison of the Da Vinci robotic systems (Xi and SP) and the laparoscopic system. Scientific Reports (2024).
- Female Infertility in Chronic Kidney Disease. Diagnostics (2023).
- Multicenter analytical performance evaluation of a fully automated anti-Müllerian hormone assay and reference interval determination. Clinical Biochemistry (2015).
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