Biomarker Evaluation in Cardiovascular Disease
Summary
Biomarkers have become integral to the diagnosis, risk stratification and management of cardiovascular disease. Traditional markers such as B-type natriuretic peptide and high-sensitivity cardiac troponins remain gold standards for detecting heart failure and myocardial injury, respectively. Advances in multiplex proteomic and immunoassay technologies now permit simultaneous measurement of a broad panel of proteins reflecting distinct pathophysiological pathways, including inflammation, fibrosis and cellular stress. Emerging candidates—such as soluble suppression of tumorigenicity 2 (sST2), growth differentiation factor 15 and galectin-3—offer insights into adverse remodelling and systemic responses beyond haemodynamic overload. Robust evaluation encompasses analytical validation, assessment of diagnostic accuracy via receiver operating characteristic analysis and demonstration of incremental prognostic value over established clinical models. Integration of biomarker panels into clinical workflows promises improved individualised risk prediction and therapeutic guidance, yet challenges remain in assay standardisation, inter-laboratory comparability and cost-effectiveness analyses.
Research from Nature Portfolio
No recent Nature Portfolio content available.
Biomarker Evaluation in Cardiovascular Disease publication trend
The graph below shows the total number of articles in biomarker evaluation in cardiovascular disease across all publications each year (not limited to Nature Index journals).
Technical terms
Biomarker: A measurable indicator of normal or pathogenic biological processes or responses to therapeutic interventions.
Soluble suppression of tumorigenicity 2 (sST2): A circulating isoform of the IL-1 receptor family that modulates myocardial stress, inflammation and fibrosis.
Natriuretic peptides: Hormonal peptides (e.g. BNP, NT-proBNP) released by cardiac myocytes in response to volume or pressure overload.
High-sensitivity troponin T (cTnT-hs): A cardiac-specific protein measured with ultrasensitive assays to detect myocardial injury.
Growth differentiation factor 15 (GDF-15): A stress-responsive cytokine linked to inflammation, oxidative stress and adverse cardiovascular outcomes.
References
- Role of Soluble ST2 Biomarker in Predicting Recurrence of Atrial Fibrillation after Electrical Cardioversion or Pulmonary Vein Isolation. International Journal of Molecular Sciences (2023).
- sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis. Inflammation (2023).
- Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study. PLOS Medicine (2021).
About these summaries
This Nature Research Intelligence Topic summary is created with the cited references and a large language model. We take care to ground generated text with facts, and have systems in place to gain human feedback on the overall quality of the process in line with our AI principles. We strive to create accurate and useful summaries for people unfamiliar with the research topic and that supports this goal. These pages are a beta release and will be updated as we learn how best to help people gain value from a research topic summary.
Turn complex research questions into confident strategic decisions
When you're under pressure to set direction, justify investment, or understand your competitive position, you need more than raw data — you need trusted insights you can act on.
Benchmark your performance against global peers using robust, methodologically sound analysis.
Combine quantitative metrics with qualitative expert insight to uncover strengths, gaps and emerging opportunities.
Gain tailored, decision-ready recommendations aligned to your strategic priorities.
Talk to us to learn more about our data dashboards and bespoke strategy reports.
Grow research skills, confidence and careers with training built for every stage of the research lifecycle.
Developed with Nature Portfolio journal Editors and internationally renowned experts. Discover three ways to learn:
Self-paced, online courses in convenient bite-sized units, covering key skills across scientific writing, publishing, grant writing, data analysis, and more.
Expert trainer-led workshops with hands-on exercises and real-time feedback across core research skills, delivered via interactive group sessions.
Editor-led workshops combining core principles in writing and publishing, personalised 1:1 feedback from Nature Portfolio Editors and hands-on exercises.
Explore course catalogues and workshop agendas, enquire about the options or request institutional pricing.