Chondromyxoid Fibroma Diagnosis and Management
Summary
Chondromyxoid fibroma (CMF) is a rare benign bone tumour arising from cartilaginous tissue, accounting for under 1% of primary bone lesions. It most commonly affects the metaphyseal region of long bones but may occur in unusual sites such as the craniofacial skeleton and axial spine. Clinically, patients present with pain, swelling or incidental radiographic findings. Imaging typically shows a well-circumscribed lytic lesion with possible septations or calcifications; magnetic resonance imaging can further characterise the myxoid and chondroid components. Definitive diagnosis relies on histopathology, which reveals lobulated areas of stellate or spindle cells set within a myxoid to chondroid matrix demarcated by fibrous septa. Surgical management remains the mainstay: intralesional curettage often supplemented by cementation or bone grafting is preferred for most lesions, while en bloc excision is reserved for recurrent or anatomically complex cases. Recurrence rates are low when meticulous surgical technique and long-term imaging follow-up are employed. Multidisciplinary approaches have enhanced reconstructive outcomes and functional preservation in challenging anatomical sites.
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Chondromyxoid Fibroma Diagnosis and Management publication trend
The graph below shows the total number of articles in chondromyxoid fibroma diagnosis and management across all publications each year (not limited to Nature Index journals).
Technical terms
Chondromyxoid fibroma (CMF): A rare benign bone tumour composed of chondroid, myxoid and fibrous tissue.
Curettage: Surgical removal of lesion tissue by scraping with a curette.
En bloc excision: Removal of the tumour in one piece with a margin of healthy tissue.
Bone grafting: Transplantation of bone material (autologous or allogeneic) to fill defects and promote healing.
Histopathology: Microscopic examination of tissue specimens to determine cellular and matrix characteristics for diagnosis.
References
- Chondromyxoid fibroma management: a single institution experience of 22 cases. World Journal of Surgical Oncology (2014).
- Chondromyxoid fibroma of the temporomandibular joint - a rare case. Cranio (2024).
- Chondromyxoid Fibroma of the Distal Tibia: A Rare Case Report. Cureus (2023).
- Chondromyxoid Fibroma of the Calcaneus: A Rare Case Report. Cureus (2022).
- Radiological evaluation of a Chondromyxoid Fibroma. Journal of Radiology and Oncology (2017).
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