Dietary Interventions and Quality of Life in Multiple Sclerosis
Summary
Multiple sclerosis (MS) is an immune-mediated disorder characterised by demyelination and neurodegeneration, often leading to physical disability, cognitive impairment and reduced health-related quality of life (HRQoL). Emerging evidence suggests that dietary factors can modulate inflammatory pathways, oxidative stress and gut microbiota composition, thereby influencing disease activity, symptom burden and overall wellbeing. Interventions ranging from broad dietary patterns—such as the Mediterranean diet, caloric restriction protocols and ketogenic regimens—to targeted nutrient supplementation (for example vitamin D, omega-3 fatty acids and polyphenols) have been investigated for their potential to attenuate immune dysregulation and promote neural repair. Personalised dietary advice based on immunological biomarkers and digital health platforms is gaining traction as a means to enhance adherence and self-management. Collectively, these approaches hold promise not only for symptom alleviation and relapse reduction but also for improving psychological health, fatigue and functional capacity in people living with MS.
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Dietary Interventions and Quality of Life in Multiple Sclerosis publication trend
The graph below shows the total number of articles in dietary interventions and quality of life in multiple sclerosis across all publications each year (not limited to Nature Index journals).
Technical terms
Polyphenols: A diverse group of plant-derived compounds with antioxidant and anti-inflammatory properties.
Hydroxycinnamic acids: A subclass of polyphenols found in fruits, vegetables and coffee, implicated in neuroprotection.
Immunoglobulin G (IgG): The most abundant antibody isotype in blood, involved in long-term immune responses and pathogen clearance.
Health-related quality of life (HRQoL): A multidimensional metric assessing physical, mental and social wellbeing in chronic disease contexts.
References
- Sociodemographic, Health, and Lifestyle-Related Characteristics Associated With the Commencement and Completion of a Web-Based Lifestyle Educational Program for People With Multiple Sclerosis: Randomized Controlled Trial. Journal of Medical Internet Research (2024).
- (Poly)phenols and Multiple Sclerosis: Results from an Observational Cross-Sectional Study. Antioxidants (2025).
- The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis. Frontiers in Immunology (2023).
- The Role of Diet and Interventions on Multiple Sclerosis: A Review. Nutrients (2022).
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