Donor-Derived Infection Management in Solid Organ Transplantation
Summary
Donor-derived infections pose a critical challenge in solid organ transplantation, where the imperative to expand donor pools must be balanced against the risk of transmitting pathogens. Management strategies encompass rigorous donor screening, peri-procurement diagnostics, targeted preservation fluid assessment and tailored prophylactic antimicrobial regimens. Advances in molecular detection, risk stratification models and early intervention protocols have reshaped clinical practice, reducing morbidity and graft loss. At the core of this field is a multidisciplinary approach that integrates microbiology, transplant immunology and clinical pharmacology to ensure patient safety without unduly constraining organ availability.
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Donor-Derived Infection Management in Solid Organ Transplantation publication trend
The graph below shows the total number of articles in donor-derived infection management in solid organ transplantation across all publications each year (not limited to Nature Index journals).
Technical terms
Donor-Derived Infection (DDI): Infection transmitted from organ donor to recipient during transplantation.
Preservation Fluid (PF): Sterile solution used to immerse and protect graft tissue during transport.
Probable Donor-Derived Infection (p-DDI): Recipient infection strongly suggestive of transmission from the donor based on microbiological matching and clinical timing.
Multidrug-Resistant Organism (MDRO): Pathogen resistant to multiple antimicrobial classes, posing treatment challenges.
Nanopore Targeted Sequencing (NTS): Rapid DNA-based method for detecting microbial pathogens by threading nucleic acids through nanoscale pores.
References
- Establishment of a risk prediction model for multidrug-resistant bacteria in deceased organ donors: a retrospective cohort study in China. Frontiers in Cellular and Infection Microbiology (2023).
- The utilization of nanopore targeted sequencing proves to be advantageous in the identification of infections present in deceased donors. Frontiers in Microbiology (2023).
- Effect of preservation fluid contamination and associated possible donor-derived infections on early postoperative prognosis in kidney transplant recipients. BMC Microbiology (2024).
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