Electrochemical Biosensing Technologies Using Carbon Nanomaterials

Summary

Electrochemical biosensors exploit the direct conversion of biochemical interactions into measurable electrical signals. Carbon nanomaterials—including carbon nanotubes, graphene and its derivatives, carbon quantum dots and nanodiamonds—have emerged as key enabling components owing to their exceptional electrical conductivity, large surface‐to‐volume ratio and favourable biocompatibility. These properties enhance electron transfer kinetics, lower detection limits and support the immobilisation of biorecognition elements such as enzymes, antibodies or nucleic acids. Surface functionalisation strategies allow selective attachment of receptors while preserving their activity, and nanostructured architectures can be tailored to tune sensitivity, dynamic range and response time. Current platforms range from disposable test strips and wearable patches to implantable microelectrodes, addressing applications in point-of-care diagnostics, environmental monitoring, food safety and continuous health surveillance. Integration with microfluidics and wireless readouts further amplifies global accessibility and paves the way for real-time multiplexed analysis in resource-limited settings.

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Electrochemical Biosensing Technologies Using Carbon Nanomaterials publication trend

The graph below shows the total number of articles in electrochemical biosensing technologies using carbon nanomaterials across all publications each year (not limited to Nature Index journals).

Technical terms

Bioreceptor: A biological molecule (enzyme, antibody or nucleic acid) that selectively recognises the target analyte.

Transducer: The component that converts a biological recognition event into an electrical signal.

Faradaic current: The current arising from redox reactions at the electrode interface during analyte detection.

Limit of detection: The lowest concentration of an analyte that can be reliably distinguished from a blank signal.

Functionalisation: Chemical or physical modification of a nanomaterial surface to attach bioreceptors or enhance selectivity.

References

  1. Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information. Nano-Micro Letters (2023).
  2. Electrochemical Sensors and Their Applications: A Review. Chemosensors (2022).
  3. Review—Recent Advances in Carbon Nanomaterials as Electrochemical Biosensors. Journal of The Electrochemical Society (2020).
  4. Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors. ECS Sensors Plus (2022).

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