Essential Oil Composition and Bioactivity in Medicinal and Aromatic Plants

Summary

Essential oils are complex blends of volatile secondary metabolites chiefly comprising monoterpenes, sesquiterpenes and phenolic compounds. Their chemical profiles are shaped by species genetics, developmental stage, geographic origin and extraction method. Modern analytical techniques have revealed fine variations in compound classes—such as oxygenated monoterpenes (e.g. linalool, 1,8-cineole) and hydrocarbon monoterpenes (e.g. limonene, α-pinene)—that underpin a spectrum of biological activities. These activities encompass broad-spectrum antimicrobial and antifungal effects, antioxidant and free-radical scavenging capacity, anti-inflammatory and analgesic actions, and inhibition of key metabolic enzymes relevant to diabetes management. Integration of phytochemical data with pharmacological assays has validated traditional uses of aromatic plants and has driven interest in natural preservatives, cosmeceuticals and adjuvant therapeutics. Recent advances emphasise the interplay between plant ecology, chemotypic diversity and bioefficacy, highlighting routes to optimise oil yield and activity through selective breeding and standardised cultivation.

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Essential Oil Composition and Bioactivity in Medicinal and Aromatic Plants publication trend

The graph below shows the total number of articles in essential oil composition and bioactivity in medicinal and aromatic plants across all publications each year (not limited to Nature Index journals).

Technical terms

Gas chromatography–mass spectrometry (GC-MS): Analytical technique separating volatile compounds and identifying them by mass spectral fragmentation patterns.

Monoterpene: A 10-carbon isoprenoid, often volatile, contributing to aroma and bioactivity (e.g. limonene, linalool).

Sesquiterpene: A 15-carbon isoprenoid with higher molecular weight than monoterpenes, often with potent pharmacological properties.

Chemotype: A plant population characterised by a distinct profile of major essential oil constituents.

DPPH radical scavenging assay: A method to evaluate antioxidant capacity by measuring the reduction of the DPPH free radical.

Minimum inhibitory concentration (MIC): The lowest concentration of an antimicrobial agent that prevents visible growth of a microorganism.

α-Amylase and α-glucosidase inhibitors: Compounds that slow carbohydrate digestion by blocking enzymes, thereby reducing post-prandial blood glucose levels.

References

  1. Phytochemical analysis and evaluation of antimicrobial, antioxidant, and antidiabetic activities of essential oils from Moroccan medicinal plants: Mentha suaveolens, Lavandula stoechas, and Ammi visnaga. Biomedicine & Pharmacotherapy (2023).
  2. Chemical Composition of Two Different Lavender Essential Oils and Their Effect on Facial Skin Microbiota. Molecules (2019).
  3. Latitude and Altitude Influence Secondary Metabolite Production in Peripheral Alpine Populations of the Mediterranean Species Lavandula angustifolia Mill.. Frontiers in Plant Science (2018).

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