Genetic Association of Inflammatory Mediators in Cardiovascular Disease
Summary
Cardiovascular disease arises from a complex interplay between genetic factors and inflammatory pathways. Genetic variants affecting the expression or function of inflammatory mediators such as cytokines, adhesion molecules and acute-phase proteins contribute to individual susceptibility, disease progression and clinical outcomes. Single nucleotide polymorphisms in promoter regions, exonic sequences and untranslated regions may alter transcriptional regulation, protein stability or receptor binding, thereby modulating vascular inflammation, plaque development and thrombosis. Advancements in genome-wide association studies and high-throughput sequencing have identified key loci associated with variations in interleukin-6, tumour necrosis factor-α and other mediators. These genetic insights offer potential for refined risk stratification, personalised therapeutics targeting inflammation and improved prognostic tools across diverse populations.
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Genetic Association of Inflammatory Mediators in Cardiovascular Disease publication trend
The graph below shows the total number of articles in genetic association of inflammatory mediators in cardiovascular disease across all publications each year (not limited to Nature Index journals).
Technical terms
Single nucleotide polymorphism (SNP): A variation at a single base position in the genome among individuals.
Allele: One of two or more alternative forms of a gene at a particular locus.
Genotype: The specific combination of alleles an individual carries at a genetic locus.
Cytokine: A small protein secreted by immune cells that mediates and regulates inflammation and immune responses.
Promoter region: A DNA sequence upstream of a gene that controls transcription initiation by binding transcription factors.
Meta-analysis: A statistical approach that combines data from multiple independent studies to derive pooled estimates.
References
- The Interleukin 6 Protein Level as well as a Genetic Variants, (rs1800795, rs1800797) Are Associated with Adverse Cardiovascular Outcomes within 10-Years Follow-Up. Cells (2023).
- Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis. Inflammation Research (2021).
- The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk. Journal of Cellular and Molecular Medicine (2020).
- Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation*. Journal of Biological Chemistry (2000).
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