Helicobacter Pylori Eradication Strategies for Gastric Cancer Prevention
Summary
Helicobacter pylori infection is established as the primary aetiological agent in non-cardia gastric cancer, instigating a cascade of chronic gastritis, atrophy and subsequent intestinal metaplasia. Eradication strategies have transitioned from conventional proton-pump inhibitor-based triple therapy to bismuth-containing quadruple regimens and susceptibility-guided approaches, addressing rising antibiotic resistance. Integration of microbial profiling, adjunctive probiotic supplementation and tailored antibiotic combinations has enhanced clearance rates and minimised dysbiosis. Complementary to pharmacological interventions, risk stratification based on endoscopic grading of gastric atrophy and metaplasia directs surveillance intervals, ensuring early detection of residual or metachronous neoplasms. Collectively, eradication not only decreases the incidence of primary gastric cancer in asymptomatic populations but also mitigates recurrence following endoscopic resection of neoplastic lesions. These strategies, underpinned by regional resistance patterns and longitudinal endoscopic follow-up, form the cornerstone of global efforts to prevent gastric malignancy.
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Helicobacter Pylori Eradication Strategies for Gastric Cancer Prevention publication trend
The graph below shows the total number of articles in helicobacter pylori eradication strategies for gastric cancer prevention across all publications each year (not limited to Nature Index journals).
Technical terms
Helicobacter pylori: A spiral Gram-negative bacterium colonising the gastric mucosa and triggering chronic inflammation.
Atrophic gastritis: Chronic inflammation leading to loss of gastric glandular cells and thinning of the stomach lining.
Intestinal metaplasia: Replacement of normal gastric epithelium with intestinal-type cells, representing a premalignant state.
Metachronous lesions: New neoplastic growths arising at separate sites after initial treatment of gastric neoplasms.
Antibiotic resistance: The capacity of H. pylori strains to withstand standard antimicrobial agents, reducing eradication success.
References
- Risk of gastric cancer in the second decade of follow-up after Helicobacter pylori eradication. Journal of Gastroenterology (2019).
- Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication. Surgical Endoscopy (2016).
- Helicobacter pylori Eradication on the Prevention of Metachronous Lesions after Endoscopic Resection of Gastric Neoplasm: A Meta-Analysis. PLOS ONE (2015).
- Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond. International Journal of Molecular Sciences (2017).
- Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance. Helicobacter (2018).
- Effectiveness of Helicobacter pylori eradication in the prevention of primary gastric cancer in healthy asymptomatic people: A systematic review and meta-analysis comparing risk ratio with risk difference. PLOS ONE (2017).
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