Individualized Ovarian Stimulation in Assisted Reproductive Technologies
Summary
Individualized ovarian stimulation tailors exogenous gonadotropin regimens to each patient’s ovarian reserve and clinical profile rather than applying uniform dosing. By integrating biomarkers such as anti-Müllerian hormone and antral follicle count with demographic factors and prior cycle characteristics, protocols aim to optimise oocyte yield, maximise live birth probability and minimise risks such as ovarian hyperstimulation syndrome. Recent advances encompass algorithm- and model-based dosing strategies, incorporation of pharmacokinetic insights and the use of machine-learning tools to refine dose selection. This personalised approach reflects a shift towards precision reproductive medicine, offering improved safety, cost-effectiveness and patient satisfaction across diverse populations.
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Individualized Ovarian Stimulation in Assisted Reproductive Technologies publication trend
The graph below shows the total number of articles in individualized ovarian stimulation in assisted reproductive technologies across all publications each year (not limited to Nature Index journals).
Technical terms
Anti-Müllerian hormone (AMH): A glycoprotein hormone secreted by ovarian follicles, used as a quantitative marker of ovarian reserve.
Antral follicle count (AFC): The number of small follicles visualised by ultrasound at the start of a menstrual cycle, reflecting ovarian reserve.
Controlled ovarian stimulation (COS): The administration of exogenous gonadotropins to induce the development of multiple ovarian follicles for assisted reproduction.
Gonadotropins: Hormones, notably follicle-stimulating hormone and luteinising hormone, used to stimulate follicular growth in assisted reproductive treatments.
Ovarian hyperstimulation syndrome (OHSS): A potentially serious complication of ovarian stimulation characterised by enlarged ovaries and fluid shifts.
Individual participant data meta-analysis (IPD-MA): A method of combining raw data from multiple studies to develop and validate prediction models at the participant level.
Follitropin delta: A recombinant follicle-stimulating hormone with unique glycosylation, dosed according to an AMH- and weight-based algorithm to individualise stimulation.
References
- Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis. Human Reproduction Update (2024).
- IDoser: Improving individualized dosing policies with clinical practice and machine learning. Expert Systems with Applications (2024).
- Individualized dosing of follitropin delta affects live birth and safety in in vitro fertilization treatment: an individual participant data meta-analysis of randomized controlled trials. Fertility and Sterility (2024).
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