Integrative Approaches to COVID-19 Management
Summary
Integrative approaches to COVID-19 management encompass a coordinated application of conventional medical treatments alongside evidence-informed complementary therapies, public health strategies and digital health tools. This paradigm seeks to address the viral infection and its sequelae through antiviral agents, immunomodulatory supplements, herbal formulations, supportive rehabilitation and psychosocial care. By aligning pharmaceutical interventions with nutraceuticals, mind–body practices and community-based monitoring, such strategies aim to attenuate the severity of acute illness, accelerate functional recovery and reduce long-term complications.
Key elements include the use of polyherbal compounds that exhibit antiviral and anti-inflammatory properties, the deployment of telemedicine for remote symptom tracking and adherence support, and the integration of traditional knowledge systems within mainstream protocols. Safety assessments and pharmacokinetic evaluations underpin the responsible co-administration of botanical extracts with authorised drugs. Collectively, these integrative models contribute to global efforts by offering scalable, culturally attuned and potentially cost-effective options that complement vaccination and standard of care.
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Integrative Approaches to COVID-19 Management publication trend
The graph below shows the total number of articles in integrative approaches to covid-19 management across all publications each year (not limited to Nature Index journals).
Technical terms
Integrative medicine: A holistic paradigm combining conventional medical treatments with complementary therapies and lifestyle interventions to optimise patient outcomes.
Polyherbal formulation: A multi-ingredient herbal product developed to exploit synergistic pharmacological effects of botanical constituents.
Randomised controlled trial: A clinical study in which participants are randomly allocated to treatment or control groups to assess the efficacy and safety of interventions.
Pharmacokinetics: The study of how a drug is absorbed, distributed, metabolised and excreted by the body.
CYP-450 enzymes: A family of liver enzymes critical for the metabolism of many drugs and xenobiotic compounds, relevant to herb–drug interaction assessments.
References
- AYUSH-64 as an adjunct to standard care in mild to moderate COVID-19: An open-label randomized controlled trial in Chandigarh, India. Complementary Therapies in Medicine (2022).
- Disease Characteristics, Care-Seeking Behavior, and Outcomes Associated With the Use of AYUSH-64 in COVID-19 Patients in Home Isolation in India: A Community-Based Cross-Sectional Analysis. Frontiers in Public Health (2022).
- In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the management of COVID-19. Frontiers in Pharmacology (2022).
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