Magnetic Resonance Imaging in Canine Intracranial Neoplasia
Summary
Magnetic resonance imaging (MRI) has become the cornerstone for non-invasive characterisation of brain tumours in dogs, offering unparalleled soft-tissue contrast and multiplanar capabilities. Conventional sequences such as T1- and T2-weighted imaging, fluid-attenuated inversion recovery and contrast-enhanced studies delineate tumour morphology, margins, perilesional oedema and mass effect. Advanced techniques—including diffusion-weighted imaging, perfusion MRI and magnetic resonance spectroscopy—provide insights into cellular density, vascularity and metabolic profiles, aiding in differentiation of gliomas, meningiomas and other neoplastic or inflammatory mimics. High-resolution volumetric analysis enables objective monitoring of tumour progression or regression during therapeutic trials. Integration of MRI with frameless or frame-based stereotactic systems facilitates precise biopsy planning and targeted interventions. As canine intracranial neoplasia serves as both a veterinary concern and a translational model for human neuro-oncology, MRI advances contribute to improved prognosis, personalised treatment and cross-species research collaborations.
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Magnetic Resonance Imaging in Canine Intracranial Neoplasia publication trend
The graph below shows the total number of articles in magnetic resonance imaging in canine intracranial neoplasia across all publications each year (not limited to Nature Index journals).
Technical terms
Magnetic Resonance Imaging (MRI): Non-invasive imaging technique that uses magnetic fields and radiofrequency pulses to generate detailed images of soft tissues.
T1-weighted imaging: MRI sequence producing high contrast between fat (bright) and fluid (dark), useful for anatomical detail and contrast agent detection.
T2-weighted imaging: MRI sequence highlighting fluid as bright, aiding in identification of oedema and necrosis.
Contrast enhancement: Use of gadolinium-based agents to increase visibility of lesions with abnormal blood–brain barrier permeability.
Stereotactic device: Frame or frameless apparatus guided by imaging data to target intracranial regions for biopsy or therapy with high precision.
Volumetric analysis: Quantitative measurement of lesion size and changes over time, enabling objective assessment of treatment response.
References
- Phase I/II Trial of Urokinase Plasminogen Activator-Targeted Oncolytic Newcastle Disease Virus for Canine Intracranial Tumors. Cancers (2024).
- Frame-Based Stereotactic Biopsy of Canine Brain Masses: Technique and Clinical Results in 26 Cases. Frontiers in Veterinary Science (2015).
- Accuracy of a magnetic resonance imaging‐based 3D printed stereotactic brain biopsy device in dogs. Journal of Veterinary Internal Medicine (2020).
- Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs. Frontiers in Veterinary Science (2019).
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